Endothelial dysfunction - an early marker of cardiovascular damage in children with obesity

Ibragimova, Elnara, Garifulina, Liliya, Ибрагимова, Эльнара, Гарифулина, Лиля, Ibragimova, Elnara, Garifulina, Liliya

Халқаро илмий педиатрия журнали · 2025-yil

Annotatsiya

Endothelial dysfunction is the leading syndrome and indicator of cardiovascular disease progression in children with obesity. The article discusses the prognostic significance of determining the level of trimethylamine N-oxide (TMAO) in endothelial dysfunction, which will allow timely prevention of cardiovascular complications. The aim of the study: to determine early markers of endothelial dysfunction in children and adolescents with abdominal obesity and to assess the factors of cardiovascular risk development. Materials and methods: 55 children and adolescents with abdominal obesity aged 7-18 years were examined. All underwent anthropometric, general clinical and biochemical studies of the lipid and carbohydrate spectrum. The level of trimethylamine N-oxide (TMAO) was determined in plasma by enzyme-linked immunosorbent assay (ELISA). Study results: A relationship was found between the level of TMAO in body weight and the degree of obesity. A positive correlation between the WC /OB ratio and the TMAO level was noted. When analyzing the correlation parallels between the TMAO level and the carbohydrate and lipid metabolism indices, it was determined with the levels of insulin resistance and HDL-C. Conclusion: Elevated TMAO levels in abdominal obesity in children suggest its contribution to the subsequent development of cardiovascular risk complications.

Maqola ma’lumotlari
MualliflarIbragimova, Elnara, Garifulina, Liliya, Ибрагимова, Эльнара, Гарифулина, Лиля, Ibragimova, Elnara, Garifulina, Liliya
JurnalХалқаро илмий педиатрия журнали
NashriyotАндижон давлат тиббиёт институти; In Science МЧЖ
ISSN2181-2926, 2181-2926
Nashr sanasi2025-06-28
Jild4
Son3
Betlar1021-1025
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/2181-2926-2025-4-3-1021-1025
Indeksga qo‘shilgan2026-08-26

DOI: 10.56121/2181-2926-2025-4-3-1021-1025 · Maqolaning asl sahifasi

Kalit so‘zlar

эндотелиальная дисфункция, дети, абдоминальное ожирение, маркеры, триметиламин N-оксид, endothelial dysfunction, children, abdominal obesity, markers, trimethylamine N-oxide, endotelial disfunksiya, bolalar, abdominal semizlik, markerlar, trimetilamin N-oksid

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAIbragimova, Elnara, Garifulina, Liliya, Ибрагимова, Эльнара, Гарифулина, Лиля, Ibragimova, Elnara, & Garifulina, Liliya (2025). ENDOTHELIAL DYSFUNCTION - AN EARLY MARKER OF CARDIOVASCULAR DAMAGE IN CHILDREN WITH OBESITY. Халқаро илмий педиатрия журнали, 4(3), 1021-1025. https://doi.org/10.56121/2181-2926-2025-4-3-1021-1025
GOST (OAK)Ibragimova, Elnara va b. ENDOTHELIAL DYSFUNCTION - AN EARLY MARKER OF CARDIOVASCULAR DAMAGE IN CHILDREN WITH OBESITY // Халқаро илмий педиатрия журнали. – 2025. – T. 4, № 3. – P. 1021-1025. – DOI: 10.56121/2181-2926-2025-4-3-1021-1025.
MLAIbragimova, Elnara, Garifulina, Liliya, Ибрагимова, Эльнара, Гарифулина, Лиля, Ibragimova, Elnara, and Garifulina, Liliya. “ENDOTHELIAL DYSFUNCTION - AN EARLY MARKER OF CARDIOVASCULAR DAMAGE IN CHILDREN WITH OBESITY.” Халқаро илмий педиатрия журнали, 4(3), 1021-1025, 2025. https://doi.org/10.56121/2181-2926-2025-4-3-1021-1025
ChicagoIbragimova, Elnara, Garifulina, Liliya, Ибрагимова, Эльнара, Гарифулина, Лиля, Ibragimova, Elnara, and Garifulina, Liliya. “ENDOTHELIAL DYSFUNCTION - AN EARLY MARKER OF CARDIOVASCULAR DAMAGE IN CHILDREN WITH OBESITY.” Халқаро илмий педиатрия журнали, 4(3), 1021-1025 (2025). https://doi.org/10.56121/2181-2926-2025-4-3-1021-1025
HarvardIbragimova, Elnara, Garifulina, Liliya, Ибрагимова, Эльнара, Гарифулина, Лиля, Ibragimova, Elnara, and Garifulina, Liliya (2025) ‘ENDOTHELIAL DYSFUNCTION - AN EARLY MARKER OF CARDIOVASCULAR DAMAGE IN CHILDREN WITH OBESITY’, Халқаро илмий педиатрия журнали, 4(3), 1021-1025. https://doi.org/10.56121/2181-2926-2025-4-3-1021-1025
BibTeX
@article{ibragimovaelnara2025,
  title = {ENDOTHELIAL DYSFUNCTION - AN EARLY MARKER OF CARDIOVASCULAR DAMAGE IN CHILDREN WITH OBESITY},
  author = {Ibragimova, Elnara and Garifulina, Liliya and Ибрагимова, Эльнара and Гарифулина, Лиля and Ibragimova, Elnara and Garifulina, Liliya},
  journal = {Халқаро илмий педиатрия журнали},
  year = {2025},
  volume = {4},
  number = {3},
  pages = {1021-1025},
  doi = {10.56121/2181-2926-2025-4-3-1021-1025},
  url = {https://doi.org/10.56121/2181-2926-2025-4-3-1021-1025}
}

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