Markers of endothelial dysfunction in children with obesity

Ibragimova, Elnara, Garifulina, Liliya, Ибрагимова, Эльнара, Лиля, Ibragimova, Elnara, Garifulina, Liliya

Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi · 2025-yil

Annotatsiya

Endothelial dysfunction plays a leading role in the progression of cardiovascular disease in children with obesity. The article discusses the prognostic values of early markers of endothelial dysfunction in children with obesity. The aim of the study: to study early markers of endothelial dysfunction in children and adolescents with abdominal obesity to predict the development of cardiovascular risk. Materials and methods: A total of 56 obese children aged 10-18 years were examined on an outpatient basis. Anthropometric, general clinical and biochemical studies of the lipid and carbohydrate spectrum were performed in all study groups. The levels of leptin, trimethylamine-N-oxide (TMAO) and von Willebrand factor (vWF) were determined in plasma by enzyme-linked immunosorbent assay (ELISA). Study results: A close relationship between severe obesity in children with hyperleptinemia and leptin resistance was revealed. The highest values of the von Willebrand factor content and TMAO level were found in children with abdominal obesity. In children with a uniform type of obesity, these indicators had moderate values. Conclusion: Leptin resistance, elevated levels of TMAO and von Willebrand factor lead to endothelial dysfunction and, accordingly, a high risk of developing cardiovascular pathology in children with abdominal obesity.

Maqola ma’lumotlari
MualliflarIbragimova, Elnara, Garifulina, Liliya, Ибрагимова, Эльнара, Лиля, Ibragimova, Elnara, Garifulina, Liliya
JurnalMedical science of Uzbekistan / O'zbekiston tibbiyot ilmi
NashriyotАндижон давлат тиббиёт институти
ISSN2181-3612
Nashr sanasi2025-06-28
Jild4
Son3
Betlar107-111
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/2181-3612-2025-3-107-111
Indeksga qo‘shilgan2026-08-26

DOI: 10.56121/2181-3612-2025-3-107-111 · Maqolaning asl sahifasi

Kalit so‘zlar

endothelial dysfunction, children, abdominal obesity, leptin, trimethylamine N-oxide, von Willebrand factor, эндотелиальная дисфункция, дети, абдоминальное ожирение, лептин, триметиламин N-оксид, фактора Виллибранда, endotelial disfunktsiya, bolalar, abdominal semizligi, leptin, trimetilamin N-oksid, Villebrand omili

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAIbragimova, Elnara, Garifulina, Liliya, Ибрагимова, Эльнара, Лиля, Ibragimova, Elnara, & Garifulina, Liliya (2025). MARKERS OF ENDOTHELIAL DYSFUNCTION IN CHILDREN WITH OBESITY. Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(3), 107-111. https://doi.org/10.56121/2181-3612-2025-3-107-111
GOST (OAK)Ibragimova, Elnara va b. MARKERS OF ENDOTHELIAL DYSFUNCTION IN CHILDREN WITH OBESITY // Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi. – 2025. – T. 4, № 3. – P. 107-111. – DOI: 10.56121/2181-3612-2025-3-107-111.
MLAIbragimova, Elnara, Garifulina, Liliya, Ибрагимова, Эльнара, Лиля, Ibragimova, Elnara, and Garifulina, Liliya. “MARKERS OF ENDOTHELIAL DYSFUNCTION IN CHILDREN WITH OBESITY.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(3), 107-111, 2025. https://doi.org/10.56121/2181-3612-2025-3-107-111
ChicagoIbragimova, Elnara, Garifulina, Liliya, Ибрагимова, Эльнара, Лиля, Ibragimova, Elnara, and Garifulina, Liliya. “MARKERS OF ENDOTHELIAL DYSFUNCTION IN CHILDREN WITH OBESITY.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(3), 107-111 (2025). https://doi.org/10.56121/2181-3612-2025-3-107-111
HarvardIbragimova, Elnara, Garifulina, Liliya, Ибрагимова, Эльнара, Лиля, Ibragimova, Elnara, and Garifulina, Liliya (2025) ‘MARKERS OF ENDOTHELIAL DYSFUNCTION IN CHILDREN WITH OBESITY’, Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(3), 107-111. https://doi.org/10.56121/2181-3612-2025-3-107-111
BibTeX
@article{ibragimovaelnara2025,
  title = {MARKERS OF ENDOTHELIAL DYSFUNCTION IN CHILDREN WITH OBESITY},
  author = {Ibragimova, Elnara and Garifulina, Liliya and Ибрагимова, Эльнара and Лиля and Ibragimova, Elnara and Garifulina, Liliya},
  journal = {Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi},
  year = {2025},
  volume = {4},
  number = {3},
  pages = {107-111},
  doi = {10.56121/2181-3612-2025-3-107-111},
  url = {https://doi.org/10.56121/2181-3612-2025-3-107-111}
}

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