Effect of different dietary regimens on blood insulin levels in rats with metabolic syndrome

Azizova D.M., Rabimova Z.Sh., Abdullayeva S.R., Ilhomova M.A., Davlataliyeva O.B.

Гуманитар ва табиий фанлар журнали · 2026-yil

Annotatsiya

Metabolic syndrome is a complex metabolic disorder characterized by insulin resistance and an increased risk of cardiovascular diseases and type 2 diabetes. The present study aimed to evaluate the effects of different dietary regimens on blood insulin levels in rats with experimentally induced metabolic syndrome. Twenty rats were divided into four groups: intact control, metabolic syndrome with laboratory diet, metabolic syndrome with traditional diet, and metabolic syndrome with modified diet. Metabolic syndrome was induced over the first 3 months by intragastric administration of sheep mesenteric fat combined with a 10% fructose solution. A two-way mixed-design ANOVA revealed a significant group × time interaction (F(6,40) = 28.96, p < 0.001, η²p = 0.81). The modified diet produced a significant 46.6% reduction in insulin (p = 0.003), restoring levels statistically indistinguishable from healthy controls (p = 0.321), while the laboratory diet caused a further significant rise (+48.3%, p = 0.010). These findings indicate that dietary composition significantly influences insulin dynamics in metabolic syndrome, and modified dietary intervention can rapidly reverse hyperinsulinemia.

Maqola ma’lumotlari
MualliflarAzizova D.M., Rabimova Z.Sh., Abdullayeva S.R., Ilhomova M.A., Davlataliyeva O.B.
JurnalГуманитар ва табиий фанлар журнали
NashriyotEMU University
ISSN2181-4007
Nashr sanasi2026-10-31
Son38
Betlar293-296
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-11-01

Maqolaning asl sahifasi

Kalit so‘zlar

metabolic syndrome, insulin resistance, dietary intervention, hyperinsulinemia, rat model, modified diet, ANOVA.

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAAzizova D.M., Rabimova Z.Sh., Abdullayeva S.R., Ilhomova M.A., Davlataliyeva O.B. (2026). EFFECT OF DIFFERENT DIETARY REGIMENS ON BLOOD INSULIN LEVELS IN RATS WITH METABOLIC SYNDROME. Гуманитар ва табиий фанлар журнали, (38), 293-296. https://journals.tnmu.uz/index.php/gtfj/article/view/7125
GOST (OAK)Azizova D.M., Rabimova Z.Sh., Abdullayeva S.R., Ilhomova M.A., Davlataliyeva O.B. EFFECT OF DIFFERENT DIETARY REGIMENS ON BLOOD INSULIN LEVELS IN RATS WITH METABOLIC SYNDROME // Гуманитар ва табиий фанлар журнали. – 2026. – № 38. – P. 293-296.
MLAAzizova D.M., Rabimova Z.Sh., Abdullayeva S.R., Ilhomova M.A., Davlataliyeva O.B. “EFFECT OF DIFFERENT DIETARY REGIMENS ON BLOOD INSULIN LEVELS IN RATS WITH METABOLIC SYNDROME.” Гуманитар ва табиий фанлар журнали, (38), 293-296, 2026. https://journals.tnmu.uz/index.php/gtfj/article/view/7125
ChicagoAzizova D.M., Rabimova Z.Sh., Abdullayeva S.R., Ilhomova M.A., Davlataliyeva O.B. “EFFECT OF DIFFERENT DIETARY REGIMENS ON BLOOD INSULIN LEVELS IN RATS WITH METABOLIC SYNDROME.” Гуманитар ва табиий фанлар журнали, (38), 293-296 (2026). https://journals.tnmu.uz/index.php/gtfj/article/view/7125
HarvardAzizova D.M., Rabimova Z.Sh., Abdullayeva S.R., Ilhomova M.A., Davlataliyeva O.B (2026) ‘EFFECT OF DIFFERENT DIETARY REGIMENS ON BLOOD INSULIN LEVELS IN RATS WITH METABOLIC SYNDROME’, Гуманитар ва табиий фанлар журнали, (38), 293-296. https://journals.tnmu.uz/index.php/gtfj/article/view/7125
BibTeX
@article{azizovadmrabimovazshabdullayevasrilhomovamadavlataliyevaob2026,
  title = {EFFECT OF DIFFERENT DIETARY REGIMENS ON BLOOD INSULIN LEVELS IN RATS WITH METABOLIC SYNDROME},
  author = {Azizova D.M., Rabimova Z.Sh., Abdullayeva S.R., Ilhomova M.A., Davlataliyeva O.B.},
  journal = {Гуманитар ва табиий фанлар журнали},
  year = {2026},
  number = {38},
  pages = {293-296},
  url = {https://journals.tnmu.uz/index.php/gtfj/article/view/7125}
}

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