Effects of intravenous iron supplementation on clinical outcomes in patients with heart failure and iron deficiency

Рахмонов Сардор Темиркул угли, Ибрагимов Хасан Исмоилович

Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali · 2025-yil

Annotatsiya

To evaluate the impact of intravenous ferric carboxymaltose on secondary clinical outcomes in patients with chronic heart failure and iron deficiency in the randomized, double-blind, placebo-controlled trial of 135 patients with at least NYHA class II heart failure and 1 or more iron-deficiency criteria. Participants were randomized into the intervention (n = 68) and control groups (n = 67), with a 24-week follow-up. The composite endpoint was the change in the clinical status as measured by NYHA functional class, the Kansas City Cardiomyopathy Questionnaire (KCCQ), NT-proBNP, 6-minute walking distance (6MWD), and the number of heart failure hospitalizations. Major statistically significant benefits seen in the IV iron cohort compared with placebo were NYHA functional class improvement (≥1 class: 62% vs. 31%, p < 0.001), KCCQ scores (+18.6 vs. +6.2, p < 0.001), NT-proBNP levels (−420 vs. −110 pg/mL, p < 0.001), 6MWD (+64 vs. +24 meters, p < 0.001), and fewer hospitalizations (13.2% vs. 28.4%, p = 0.032). In our studied population, the administration of intravenous iron improves very significantly clinical condition, functional capacity and biological parameters, and also helps to reduce the number of hospitalizations in patients with chronic heart failure with reduced ejection fraction and deficiency of iron. The drug was well tolerated, with no meaningful differences in adverse events between the groups.

Maqola ma’lumotlari
MualliflarРахмонов Сардор Темиркул угли, Ибрагимов Хасан Исмоилович
JurnalJournal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali
NashriyotСамарқанд давлат тиббиёт университети
Nashr sanasi2025-06-06
Jild6
Son2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

сердечная недостаточность, дефицит железа, внутривенное железо, карбоксимальтозат железа, клинические исходы, функциональная способность, yurak yetishmovchiligi, temir tanqisligi, tomir ichiga yuboriladigan temir, karboksimaltozat temiri, klinik natijalar, funksional imkoniyat

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAРахмонов Сардор Темиркул угли, & Ибрагимов Хасан Исмоилович (2025). EFFECTS OF INTRAVENOUS IRON SUPPLEMENTATION ON CLINICAL OUTCOMES IN PATIENTS WITH HEART FAILURE AND IRON DEFICIENCY. Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 6(2). https://www.tadqiqot.uz/index.php/cardio/article/view/11487
GOST (OAK)Рахмонов Сардор Темиркул угли, Ибрагимов Хасан Исмоилович EFFECTS OF INTRAVENOUS IRON SUPPLEMENTATION ON CLINICAL OUTCOMES IN PATIENTS WITH HEART FAILURE AND IRON DEFICIENCY // Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali. – 2025. – T. 6, № 2.
MLAРахмонов Сардор Темиркул угли, and Ибрагимов Хасан Исмоилович. “EFFECTS OF INTRAVENOUS IRON SUPPLEMENTATION ON CLINICAL OUTCOMES IN PATIENTS WITH HEART FAILURE AND IRON DEFICIENCY.” Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 6(2), 2025. https://www.tadqiqot.uz/index.php/cardio/article/view/11487
ChicagoРахмонов Сардор Темиркул угли, and Ибрагимов Хасан Исмоилович. “EFFECTS OF INTRAVENOUS IRON SUPPLEMENTATION ON CLINICAL OUTCOMES IN PATIENTS WITH HEART FAILURE AND IRON DEFICIENCY.” Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 6(2) (2025). https://www.tadqiqot.uz/index.php/cardio/article/view/11487
HarvardРахмонов Сардор Темиркул угли, and Ибрагимов Хасан Исмоилович (2025) ‘EFFECTS OF INTRAVENOUS IRON SUPPLEMENTATION ON CLINICAL OUTCOMES IN PATIENTS WITH HEART FAILURE AND IRON DEFICIENCY’, Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 6(2). https://www.tadqiqot.uz/index.php/cardio/article/view/11487
BibTeX
@article{article2025,
  title = {EFFECTS OF INTRAVENOUS IRON SUPPLEMENTATION ON CLINICAL OUTCOMES IN PATIENTS WITH HEART FAILURE AND IRON DEFICIENCY},
  author = {Рахмонов Сардор Темиркул угли and Ибрагимов Хасан Исмоилович},
  journal = {Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali},
  year = {2025},
  volume = {6},
  number = {2},
  url = {https://www.tadqiqot.uz/index.php/cardio/article/view/11487}
}

Boshqa maqola uchun iqtibos tayyorlash

Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali jurnalidan boshqa maqolalar

Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali — barcha maqolalar · 2025-yil arxivi

Tibbiyot sohasidagi boshqa maqolalar

Tibbiyot sohasidagi OAK jurnallari