Synthesis, structural elucidation, and physicochemical profiling of novel ternary heteronuclear fe(ii)/fe(iii)–zn(ii)–cu(ii)–polygalacturonate nanocomplexes: a paradigm shift in multi-element nutraceutical delivery

Nurmatova, Mohira, Xanabatova, Madina

FarDU ilmiy xabarlari · 2026-yil

Annotatsiya

The global epidemic of micronutrient deficiencies (iron, zinc, and copper) affects over two billion individuals, yet traditional low-molecular-weight supplements are severely hampered by poor bioavailability, rapid oxidative degradation, and adverse gastrointestinal (GI) interactions. While recent Scopus-indexed literature has extensively explored binary biopolymer-metal complexes, the synthesis of ternary heteronuclear systems remains an unresolved challenge due to competitive coordination kinetics and redox instability. In this pioneering study, we report the first successful synthesis and comprehensive structural characterization of innovative ternary heteronuclear Fe/Zn/Cu complexes based on polygalacturonic acid (PGA). Utilizing a controlled co-coordination method in an aqueous medium (pH 5.0–5.5) with varying Fe:Zn:Cu molar ratios (1:1:1, 2:1:1, 1:2:1), we achieved high encapsulation efficiencies (82–89%). Advanced structural elucidation via FTIR, XRD, TGA/DSC, ICP-OES, XPS. FTIR demonstrated a shift to predominant bidentate chelating and bridging motifs (Δν decreased from 195 cm⁻¹ to 158 cm⁻¹). Crucially, XPS analysis revealed an Fe(II):Fe(III) ratio of 68:32, proving that the PGA matrix effectively passivates the biologically active Fe(II) against auto-oxidation—a significant breakthrough over previously reported binary systems. In vitro GI modeling demonstrated a pH-responsive, sustained release profile governed by Higuchi kinetics, preventing the "burst release" typical of conventional salts. Furthermore, the ternary complexes exhibited synergistic antioxidant (IC₅₀ = 42.3 µg/mL), antimicrobial, and highly biocompatible (Caco-2 cell viability >94%) properties. These findings establish a novel, highly stable multi-element nanonutraceutical platform, offering a superior alternative to current monometallic supplementation strategies.

Maqola ma’lumotlari
MualliflarNurmatova, Mohira, Xanabatova, Madina
JurnalFarDU ilmiy xabarlari
NashriyotFarg‘ona davlat universiteti
ISSN2010-8419, 2181-1571
Nashr sanasi2026-10-14
Jild7
Son5
Betlar23-44
TilIngliz
Ilmiy sohaKimyo
Indeksga qo‘shilgan2026-10-18

Maqolaning asl sahifasi

Kalit so‘zlar

Poligalakturon kislotasi; Geteroyadroli komplekslar; Temir; Rux; Mis; Nanozarrachalar; Boshqariladigan ajralib chiqish; Antioksidant faollik; Biologik mavjudlik; Sinergizm., Polygalacturonic acid; Heteronuclear complexes; Iron; Zinc; Copper; Nanoparticles; Controlled release; Antioxidant activity; Bioavailability; Synergism.

Ilmiy soha

Kimyo

Iqtibos keltirish

APANurmatova, Mohira, & Xanabatova, Madina (2026). SYNTHESIS, STRUCTURAL ELUCIDATION, AND PHYSICOCHEMICAL PROFILING OF NOVEL TERNARY HETERONUCLEAR FE(II)/FE(III)–ZN(II)–CU(II)–POLYGALACTURONATE NANOCOMPLEXES: A PARADIGM SHIFT IN MULTI-ELEMENT NUTRACEUTICAL DELIVERY. FarDU ilmiy xabarlari, 7(5), 23-44. https://journal.fdu.uz/main/article/7731
GOST (OAK)Nurmatova, Mohira, Xanabatova, Madina SYNTHESIS, STRUCTURAL ELUCIDATION, AND PHYSICOCHEMICAL PROFILING OF NOVEL TERNARY HETERONUCLEAR FE(II)/FE(III)–ZN(II)–CU(II)–POLYGALACTURONATE NANOCOMPLEXES: A PARADIGM SHIFT IN MULTI-ELEMENT NUTRACEUTICAL DELIVERY // FarDU ilmiy xabarlari. – 2026. – T. 7, № 5. – P. 23-44.
MLANurmatova, Mohira, and Xanabatova, Madina. “SYNTHESIS, STRUCTURAL ELUCIDATION, AND PHYSICOCHEMICAL PROFILING OF NOVEL TERNARY HETERONUCLEAR FE(II)/FE(III)–ZN(II)–CU(II)–POLYGALACTURONATE NANOCOMPLEXES: A PARADIGM SHIFT IN MULTI-ELEMENT NUTRACEUTICAL DELIVERY.” FarDU ilmiy xabarlari, 7(5), 23-44, 2026. https://journal.fdu.uz/main/article/7731
ChicagoNurmatova, Mohira, and Xanabatova, Madina. “SYNTHESIS, STRUCTURAL ELUCIDATION, AND PHYSICOCHEMICAL PROFILING OF NOVEL TERNARY HETERONUCLEAR FE(II)/FE(III)–ZN(II)–CU(II)–POLYGALACTURONATE NANOCOMPLEXES: A PARADIGM SHIFT IN MULTI-ELEMENT NUTRACEUTICAL DELIVERY.” FarDU ilmiy xabarlari, 7(5), 23-44 (2026). https://journal.fdu.uz/main/article/7731
HarvardNurmatova, Mohira, and Xanabatova, Madina (2026) ‘SYNTHESIS, STRUCTURAL ELUCIDATION, AND PHYSICOCHEMICAL PROFILING OF NOVEL TERNARY HETERONUCLEAR FE(II)/FE(III)–ZN(II)–CU(II)–POLYGALACTURONATE NANOCOMPLEXES: A PARADIGM SHIFT IN MULTI-ELEMENT NUTRACEUTICAL DELIVERY’, FarDU ilmiy xabarlari, 7(5), 23-44. https://journal.fdu.uz/main/article/7731
BibTeX
@article{nurmatovamohira2026,
  title = {SYNTHESIS, STRUCTURAL ELUCIDATION, AND PHYSICOCHEMICAL PROFILING OF NOVEL TERNARY HETERONUCLEAR FE(II)/FE(III)–ZN(II)–CU(II)–POLYGALACTURONATE NANOCOMPLEXES: A PARADIGM SHIFT IN MULTI-ELEMENT NUTRACEUTICAL DELIVERY},
  author = {Nurmatova, Mohira and Xanabatova, Madina},
  journal = {FarDU ilmiy xabarlari},
  year = {2026},
  volume = {7},
  number = {5},
  pages = {23-44},
  url = {https://journal.fdu.uz/main/article/7731}
}

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