Molecular docking of a cobalt(ii) bis-chelate of phenylglyoxylic acid thiosemicarbazone against a fungal aspartic protease and a protozoan kinase

Akhatov, Javokhirkhon, Turaev, Khayit, Ashurov, Jamshid

Қўқон ДПИ. Илмий хабарлар · 2026-yil

Annotatsiya

Kobalt(II) bis-xelati Co(PGTS)₂ Candida albicans kandidapepsin-5 va Toxoplasma gondii ROP18 kinazasiga dock qilindi. Ikkala nishonda ham kompleks erkin ligandning ikki shaklidan past ball oldi. Hal qiluvchi cheklov shundaki, hech bir retseptor redocking nazoratidan o‘tmadi: 2QZX da nazoratni o‘tkazish mumkin emas, 4JRN da esa u 3.31 Å bilan muvaffaqiyatsiz bo‘ldi. Metall atomining turi natijani umuman o‘zgartirmadi, Vinardo funksiyasi esa Vina tartibini bironta nishonda ham takrorlamadi. Shu sababli natijalar validatsiyalanmagan protokol bo‘yicha prognoz sifatida beriladi va avvalo metodik davomiy tekshirishni talab qiladi.

Maqola ma’lumotlari
MualliflarAkhatov, Javokhirkhon, Turaev, Khayit, Ashurov, Jamshid
JurnalҚўқон ДПИ. Илмий хабарлар
NashriyotҚўқон давлат педагогика институти
ISSN3030-3958
Nashr sanasi2026-10-10
Jild8
Son9
Betlar1551-1560
TilIngliz
DOI10.70728/a.series.tab.v08.i09.200
Indeksga qo‘shilgan2026-10-11

DOI: 10.70728/a.series.tab.v08.i09.200 · Maqolaning asl sahifasi

Kalit so‘zlar

kobalt(II) kompleksi, tiosemikarbazon, molekulyar docking, kandidapepsin-5, ROP18, redocking validatsiyasi, konsensus ballash

Iqtibos keltirish

APAAkhatov, Javokhirkhon, Turaev, Khayit, & Ashurov, Jamshid (2026). MOLECULAR DOCKING OF A COBALT(II) BIS-CHELATE OF PHENYLGLYOXYLIC ACID THIOSEMICARBAZONE AGAINST A FUNGAL ASPARTIC PROTEASE AND A PROTOZOAN KINASE. Қўқон ДПИ. Илмий хабарлар, 8(9), 1551-1560. https://doi.org/10.70728/a.series.tab.v08.i09.200
GOST (OAK)Akhatov, Javokhirkhon, Turaev, Khayit, Ashurov, Jamshid MOLECULAR DOCKING OF A COBALT(II) BIS-CHELATE OF PHENYLGLYOXYLIC ACID THIOSEMICARBAZONE AGAINST A FUNGAL ASPARTIC PROTEASE AND A PROTOZOAN KINASE // Қўқон ДПИ. Илмий хабарлар. – 2026. – T. 8, № 9. – P. 1551-1560. – DOI: 10.70728/a.series.tab.v08.i09.200.
MLAAkhatov, Javokhirkhon, Turaev, Khayit, and Ashurov, Jamshid. “MOLECULAR DOCKING OF A COBALT(II) BIS-CHELATE OF PHENYLGLYOXYLIC ACID THIOSEMICARBAZONE AGAINST A FUNGAL ASPARTIC PROTEASE AND A PROTOZOAN KINASE.” Қўқон ДПИ. Илмий хабарлар, 8(9), 1551-1560, 2026. https://doi.org/10.70728/a.series.tab.v08.i09.200
ChicagoAkhatov, Javokhirkhon, Turaev, Khayit, and Ashurov, Jamshid. “MOLECULAR DOCKING OF A COBALT(II) BIS-CHELATE OF PHENYLGLYOXYLIC ACID THIOSEMICARBAZONE AGAINST A FUNGAL ASPARTIC PROTEASE AND A PROTOZOAN KINASE.” Қўқон ДПИ. Илмий хабарлар, 8(9), 1551-1560 (2026). https://doi.org/10.70728/a.series.tab.v08.i09.200
HarvardAkhatov, Javokhirkhon, Turaev, Khayit, and Ashurov, Jamshid (2026) ‘MOLECULAR DOCKING OF A COBALT(II) BIS-CHELATE OF PHENYLGLYOXYLIC ACID THIOSEMICARBAZONE AGAINST A FUNGAL ASPARTIC PROTEASE AND A PROTOZOAN KINASE’, Қўқон ДПИ. Илмий хабарлар, 8(9), 1551-1560. https://doi.org/10.70728/a.series.tab.v08.i09.200
BibTeX
@article{akhatovjavokhirkhon2026,
  title = {MOLECULAR DOCKING OF A COBALT(II) BIS-CHELATE OF PHENYLGLYOXYLIC ACID THIOSEMICARBAZONE AGAINST A FUNGAL ASPARTIC PROTEASE AND A PROTOZOAN KINASE},
  author = {Akhatov, Javokhirkhon and Turaev, Khayit and Ashurov, Jamshid},
  journal = {Қўқон ДПИ. Илмий хабарлар},
  year = {2026},
  volume = {8},
  number = {9},
  pages = {1551-1560},
  doi = {10.70728/a.series.tab.v08.i09.200},
  url = {https://doi.org/10.70728/a.series.tab.v08.i09.200}
}

Boshqa maqola uchun iqtibos tayyorlash

Қўқон ДПИ. Илмий хабарлар jurnalidan boshqa maqolalar

Қўқон ДПИ. Илмий хабарлар — barcha maqolalar · 2026-yil arxivi

Akhatov, Javokhirkhon — boshqa maqolalari