Molecular docking of a cobalt(ii) bis-chelate of phenylglyoxylic acid thiosemicarbazone against human kinase and oxidoreductase targets

Akhatov, Javokhirkhon, Turaev, Khayit, Ashurov, Jamshid, Sodikov, Obid

Қўқон ДПИ. Илмий хабарлар · 2026-yil

Annotatsiya

Kobalt(II) bis-xelati Co(PGTS)₂ oltita inson protein nishoniga dock qilindi; to‘rttasi oldindan belgilangan quti qoidasi bo‘yicha dock qilindi va faqat bittasi — EGFR (3W2S) — redocking validatsiyasidan o‘tdi. Kompleks to‘rttadan uchtasida erkin ligandning ikki shaklidan past ball oldi; DHODH (6LZL) yagona istisno bo‘lib qoldi. Eng katta ajralish ERK2 (4FUX) da qayd etildi, biroq u validatsiyalanmagan retseptorga tayanadi. Metall atomining turi natijani umuman o‘zgartirmadi, Vinardo funksiyasi esa Vina tartibini bironta nishonda ham takrorlamadi, bu esa xulosani sezilarli cheklaydi.

Maqola ma’lumotlari
MualliflarAkhatov, Javokhirkhon, Turaev, Khayit, Ashurov, Jamshid, Sodikov, Obid
JurnalҚўқон ДПИ. Илмий хабарлар
NashriyotҚўқон давлат педагогика институти
ISSN3030-3958
Nashr sanasi2026-10-10
Jild8
Son9
Betlar1561-1571
TilIngliz
DOI10.70728/a.series.tab.v08.i09.201
Indeksga qo‘shilgan2026-10-11

DOI: 10.70728/a.series.tab.v08.i09.201 · Maqolaning asl sahifasi

Kalit so‘zlar

kobalt(II) kompleksi, tiosemikarbazon, molekulyar docking, EGFR, DHODH, tanlanmaganlik, redocking validatsiyasi, konsensus ballash

Iqtibos keltirish

APAAkhatov, Javokhirkhon, Turaev, Khayit, Ashurov, Jamshid, & Sodikov, Obid (2026). MOLECULAR DOCKING OF A COBALT(II) BIS-CHELATE OF PHENYLGLYOXYLIC ACID THIOSEMICARBAZONE AGAINST HUMAN KINASE AND OXIDOREDUCTASE TARGETS. Қўқон ДПИ. Илмий хабарлар, 8(9), 1561-1571. https://doi.org/10.70728/a.series.tab.v08.i09.201
GOST (OAK)Akhatov, Javokhirkhon va b. MOLECULAR DOCKING OF A COBALT(II) BIS-CHELATE OF PHENYLGLYOXYLIC ACID THIOSEMICARBAZONE AGAINST HUMAN KINASE AND OXIDOREDUCTASE TARGETS // Қўқон ДПИ. Илмий хабарлар. – 2026. – T. 8, № 9. – P. 1561-1571. – DOI: 10.70728/a.series.tab.v08.i09.201.
MLAAkhatov, Javokhirkhon, Turaev, Khayit, Ashurov, Jamshid, and Sodikov, Obid. “MOLECULAR DOCKING OF A COBALT(II) BIS-CHELATE OF PHENYLGLYOXYLIC ACID THIOSEMICARBAZONE AGAINST HUMAN KINASE AND OXIDOREDUCTASE TARGETS.” Қўқон ДПИ. Илмий хабарлар, 8(9), 1561-1571, 2026. https://doi.org/10.70728/a.series.tab.v08.i09.201
ChicagoAkhatov, Javokhirkhon, Turaev, Khayit, Ashurov, Jamshid, and Sodikov, Obid. “MOLECULAR DOCKING OF A COBALT(II) BIS-CHELATE OF PHENYLGLYOXYLIC ACID THIOSEMICARBAZONE AGAINST HUMAN KINASE AND OXIDOREDUCTASE TARGETS.” Қўқон ДПИ. Илмий хабарлар, 8(9), 1561-1571 (2026). https://doi.org/10.70728/a.series.tab.v08.i09.201
HarvardAkhatov, Javokhirkhon, Turaev, Khayit, Ashurov, Jamshid, and Sodikov, Obid (2026) ‘MOLECULAR DOCKING OF A COBALT(II) BIS-CHELATE OF PHENYLGLYOXYLIC ACID THIOSEMICARBAZONE AGAINST HUMAN KINASE AND OXIDOREDUCTASE TARGETS’, Қўқон ДПИ. Илмий хабарлар, 8(9), 1561-1571. https://doi.org/10.70728/a.series.tab.v08.i09.201
BibTeX
@article{akhatovjavokhirkhon2026,
  title = {MOLECULAR DOCKING OF A COBALT(II) BIS-CHELATE OF PHENYLGLYOXYLIC ACID THIOSEMICARBAZONE AGAINST HUMAN KINASE AND OXIDOREDUCTASE TARGETS},
  author = {Akhatov, Javokhirkhon and Turaev, Khayit and Ashurov, Jamshid and Sodikov, Obid},
  journal = {Қўқон ДПИ. Илмий хабарлар},
  year = {2026},
  volume = {8},
  number = {9},
  pages = {1561-1571},
  doi = {10.70728/a.series.tab.v08.i09.201},
  url = {https://doi.org/10.70728/a.series.tab.v08.i09.201}
}

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