In recent days, among patients with coronary artery disease, there have been frequent cases of asymptomatic and clinically pronounced hyperuricemia, which threaten the lives of patients with cardiovascular pathologies; therefore, interest in studying the course of hyperuricemia in patients with cardiovascular diseases is increasing. Objective: to study the relationship between the polymorphism of the -819 C/T locus (rs1800871) of the IL-10 gene and the progression of unstable angina in patients with neurosensory disorders. Materials and methods of research: In the clinical base of the Samarkand branch of the Republican Scientific Center for Emergency Medical Care (SFRSCEMC) from 2019 to 2021. 97 patients diagnosed with coronary heart disease (CHD) were examined. The average age of patients with coronary artery disease was 61.56±12.31 years. Results of the study: All patients were divided into 2 groups depending on the presence of neurosensory disorders. During the study, neurosensory disorders (NSD) were identified in 67 patients. To determine the association of 819 (rs1800871) C/T polymorphism of the IL-10 gene with HCP, the distributions of the C and T allele frequencies of the gene in the group of АS patients with and without HCP were studied, and in the group of practically healthy individuals it was found that the C and T alleles of the gene IL-10 (C819T) rs1800871 occurred at different frequencies. Conclusions: Thus, the modern methods of laboratory diagnostics given in this study made it possible to confirm the importance of the participation of biochemical, immunological and genetic mechanisms in the pathogenesis of the development of IHD destabilization, which, in turn, will contribute to the improvement and individual approach to the treatment and prevention of this pathological disease. conditions, as well as improve prognosis and reduce cardiovascular complications and mortality.
| Mualliflar | Насырова Зарина Акбаровна |
|---|---|
| Jurnal | Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali |
| Nashriyot | Самарқанд давлат тиббиёт университети |
| Nashr sanasi | 2022-10-07 |
| Jild | 3 |
| Son | 3 |
| Til | Ingliz |
| Ilmiy soha | Tibbiyot |
| Indeksga qo‘shilgan | 2026-08-26 |
ишемическая болезнь сердца, интерлейкин, мочевая кислота, нейросенсорные расстройства, нестабильная стенокардия, бессимптомная гиперурикемия, ischemic heart disease, interleukin, uric acid, neurosensory disorders, unstable angina, asymptomatic hyperuricemia, yurak ishemik kasalligi, interleykin, siydik kislotasi, neyrosensor buzilishlar, beqaror atenokardiya, asimptomatik giperurikemiya
| APA | Насырова Зарина Акбаровна (2022). THE ROLE OF IL-10 GENE -819 C/T (rs1800871) POLYMORPHISM IN DESTABILIZATION OF CORONARY HEART DISEASE IN PATIENTS WITH NEUROSENSORY DISORDERS. Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 3(3). https://www.tadqiqot.uz/index.php/cardio/article/view/5576 |
|---|---|
| GOST (OAK) | Насырова Зарина Акбаровна THE ROLE OF IL-10 GENE -819 C/T (rs1800871) POLYMORPHISM IN DESTABILIZATION OF CORONARY HEART DISEASE IN PATIENTS WITH NEUROSENSORY DISORDERS // Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali. – 2022. – T. 3, № 3. |
| MLA | Насырова Зарина Акбаровна. “THE ROLE OF IL-10 GENE -819 C/T (rs1800871) POLYMORPHISM IN DESTABILIZATION OF CORONARY HEART DISEASE IN PATIENTS WITH NEUROSENSORY DISORDERS.” Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 3(3), 2022. https://www.tadqiqot.uz/index.php/cardio/article/view/5576 |
| Chicago | Насырова Зарина Акбаровна. “THE ROLE OF IL-10 GENE -819 C/T (rs1800871) POLYMORPHISM IN DESTABILIZATION OF CORONARY HEART DISEASE IN PATIENTS WITH NEUROSENSORY DISORDERS.” Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 3(3) (2022). https://www.tadqiqot.uz/index.php/cardio/article/view/5576 |
| Harvard | Насырова Зарина Акбаровна (2022) ‘THE ROLE OF IL-10 GENE -819 C/T (rs1800871) POLYMORPHISM IN DESTABILIZATION OF CORONARY HEART DISEASE IN PATIENTS WITH NEUROSENSORY DISORDERS’, Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 3(3). https://www.tadqiqot.uz/index.php/cardio/article/view/5576 |
| BibTeX | @article{article2022,
title = {THE ROLE OF IL-10 GENE -819 C/T (rs1800871) POLYMORPHISM IN DESTABILIZATION OF CORONARY HEART DISEASE IN PATIENTS WITH NEUROSENSORY DISORDERS},
author = {Насырова Зарина Акбаровна},
journal = {Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali},
year = {2022},
volume = {3},
number = {3},
url = {https://www.tadqiqot.uz/index.php/cardio/article/view/5576}
} |
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