Phenotypic predictors and biomarkers for forecasting the effectiveness of antimicrobial therapy

Мухсинов Фарход Мунисович, Ливерко Ирина Владимировна

Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali · 2022-yil

Annotatsiya

In order to assess the forecast of the effectiveness of antimicrobial therapy, phenotypic predictors characterizing the seriousness of the inflammatory process and the level of beta-lactamase activity (BLA) of blood serum were studied in 55 patients with exacerbation of chronic obstructive pulmonary disease and 40 patients with hospital-acquired pneumonia. According to the results, it was found that the serum beta-lactamase activity level is determined by phenotypic and clinical variables: age over 60 years, severe respiratory pathology, fever over 380, peripheral blood leukocyte level over 10x109, C-reactive protein over 40 mg/L and saturation less than 93%, correlating with an increase in UAV levels, and are predictors of low efficacy of treatment with beta-lactam antibiotics. A direct correlation was revealed between the level of serum beta-lactamase activity and the duration of antimicrobial therapy during the year (r=+0.86, p=0.001), the number of antimicrobial drugs prescribed simultaneously (r=+0.69, p=0.001), the fact of receiving beta-lactam reserve antibiotics – cefepime, imipenem, meropenem (r=+0.71, p=0.001), the fact of prescribing reserve antibiotics not related to the beta-lactam series – rifampicin, azithromycin, vancomycin, linezolid, levofloxacin (r=+0.59, p=0.001). Predicting the effectiveness of successful treatment with antibacterial drugs of the first-line beta-lactam group in the framework of evidence-based medicine, the need to determine the level of beta-lactamase activity of biological substrates is justified. Assessment of the level of beta-lactamase activity before the start of antibiotic therapy will reduce the unjustified use of beta-lactam antibiotics by up to 30%.

Maqola ma’lumotlari
MualliflarМухсинов Фарход Мунисович, Ливерко Ирина Владимировна
JurnalJournal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali
NashriyotСамарқанд давлат тиббиёт университети
Nashr sanasi2022-10-07
Jild3
Son3
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

бета-лактамазная активность, эффективность антимикробной терапии, бета-лактамные антибиотики, предикторы неэффективности, прогноз антибактериальной терапии, beta-lactamase activity, effectiveness of antimicrobial therapy, beta-lactam antibiotics, predictors of inefficiency, prognosis of antibacterial therapy, beta-laktamaz faolligi, antimikrob terapiyaning samaradorligi, beta-laktam antibiotiklari, samarasizlik belgilari, antibakterial terapiya prognozi.

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAМухсинов Фарход Мунисович, & Ливерко Ирина Владимировна (2022). PHENOTYPIC PREDICTORS AND BIOMARKERS FOR FORECASTING THE EFFECTIVENESS OF ANTIMICROBIAL THERAPY. Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 3(3). https://www.tadqiqot.uz/index.php/cardio/article/view/5574
GOST (OAK)Мухсинов Фарход Мунисович, Ливерко Ирина Владимировна PHENOTYPIC PREDICTORS AND BIOMARKERS FOR FORECASTING THE EFFECTIVENESS OF ANTIMICROBIAL THERAPY // Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali. – 2022. – T. 3, № 3.
MLAМухсинов Фарход Мунисович, and Ливерко Ирина Владимировна. “PHENOTYPIC PREDICTORS AND BIOMARKERS FOR FORECASTING THE EFFECTIVENESS OF ANTIMICROBIAL THERAPY.” Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 3(3), 2022. https://www.tadqiqot.uz/index.php/cardio/article/view/5574
ChicagoМухсинов Фарход Мунисович, and Ливерко Ирина Владимировна. “PHENOTYPIC PREDICTORS AND BIOMARKERS FOR FORECASTING THE EFFECTIVENESS OF ANTIMICROBIAL THERAPY.” Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 3(3) (2022). https://www.tadqiqot.uz/index.php/cardio/article/view/5574
HarvardМухсинов Фарход Мунисович, and Ливерко Ирина Владимировна (2022) ‘PHENOTYPIC PREDICTORS AND BIOMARKERS FOR FORECASTING THE EFFECTIVENESS OF ANTIMICROBIAL THERAPY’, Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali, 3(3). https://www.tadqiqot.uz/index.php/cardio/article/view/5574
BibTeX
@article{article2022,
  title = {PHENOTYPIC PREDICTORS AND BIOMARKERS FOR FORECASTING THE EFFECTIVENESS OF ANTIMICROBIAL THERAPY},
  author = {Мухсинов Фарход Мунисович and Ливерко Ирина Владимировна},
  journal = {Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali},
  year = {2022},
  volume = {3},
  number = {3},
  url = {https://www.tadqiqot.uz/index.php/cardio/article/view/5574}
}

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