The present pandemic and severe acute respiratory syndrome (SARS-CoV-2) have resulted in a significant number of deaths worldwide. Today the number of deaths exceeds 4.55 million people. To identify drugs for additional effective treatment of SARS-CoV-2 infection, a screen was created to measure the dimerization of angiotensin converting enzyme 2 (ACE2), the main virus entry receptor into the cell. This screen identified fenofibric acid, the active metabolite of fenofibrate. Fenofibric acid also destabilized the receptor-binding domain (RBD) of the viral spike protein and inhibited the binding of RBD to ACE2 in an enzyme-linked immunosorbent assay (ELISA). Fenofibrate and fenofibric acid have been tested by two independent laboratories. In both cases, at concentrations of the drug in clinical doses, fenofibrate and fenofibric acid reduced viral infection by up to 70%Together with an extensive history of clinical use and a relatively good safety profile, this study identifies fenofibrate as a potential therapeutic agent requiring clinical evaluation for the treatment of SARS-CoV-2 infection in comorbid patients with hypertension and high body mass index.
| Mualliflar | Агабабян Ирина Рубеновна, Журакулов Фазлиддин Норманович, Исмоилова Юлдуз Абдувохидовна |
|---|---|
| Jurnal | Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali |
| Nashr sanasi | 2022-04-02 |
| Jild | 3 |
| Son | 1 |
| Til | O‘zbek |
фенофибрат, SARS-CoV-2, ACE2, рецептор-связывающий домен (RBD), ИФА, fenofibrate, SARS-CoV-2, ACE2, receptor-binding domain (RBD), IFA, fenofibrat, SARS-CoV-2, ACE2, retseptorlarni bog’lovchi domen (RBD), IFA
The synthesis of natural auto-ABs in a healthy organism is maintained within certain limits necessary for the latter to perform certain regulatory functions, and their excess, as well as insufficient production, can…
The incidence of diabetes mellitus (DM) in patients with heart failure (HF) is about 40%, regardless of the level of ejection fraction (EF) impairment. But, in addition, diabetes is considered a strong independent risk…
The metabolic status was assessed in newborns full-term and with signs of prematurity in the early neonatal period with intrauterine hypoxia and acute asphyxia in history in order to identify possible dyselectrolytemia…
The study included 122 patients with coronary artery disease and type 2 diabetes mellitis (69 men and 53 women) receiving treatment from 38 to 72 years of age. The average length of service in the diabetes melitis…
In this study, the prevalence of coronary artery disease and risk factors in the urban unorganized population of Samarkand was studied. Examined were men and women over 40 years of age living in the same territory of a…
COPD is one of the most common human diseases, which is primarily due to the high prevalence of smoking, environmental pollution and recurrent respiratory infectious diseases. This disease is one of the most important…
Pulse pressure (PP) measured as the difference between systolic blood pressure (SBP) and diastolic blood pressure (DBP) increases markedly after the age of fifty because of the increase of arterial stiffness with age…
This article analyzes the frequency of occurrence of risk factors in unstable variants of angina pectoris among men in young and old age. All patients, depending on their age, are divided into two groups. Group 1…
Prolonged neonatal hyperbilirubinemia is a disease based on an increase in bilirubin, which is clinically manifested by hyperbilirubinemia for more than 14 days. Given the neurotoxicity of bilirubin on the body of a…
Background. Latent tuberculosis infection is an asymptomatic condition in which patients carry the bacteria, but do not show any sign of illness, however they are at risk of disease activation at any time in the future…
Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali — barcha maqolalar