Pathogenetic rationale for personalized therapy of dentin hypersensitivity in patients with erosive tooth lesions

Khusanbaeva, Jasmin Shavkatovna, Zoirov, Tulqin Elnazarovich

Мактабгача ва мактаб таълими · 2026-yil

Annotatsiya

Background: Dentin hypersensitivity (DH) is a widespread clinical condition that adversely affects the quality of life and complicates routine oral hygiene procedures. The loss of enamel and cementum due to non-carious lesions, particularly acid erosion, results in the exposure and decompensation of dentinal tubules. Conventional management strategies often rely on symptomatic relief or inadequate occlusion, highlighting the need for pathogenetically tailored interventions. Objective: To analyze current epidemiological data, pathogenetic mechanisms, diagnostic considerations, and therapeutic approaches for dentin hypersensitivity, with a particular focus on personalized treatment regimens utilizing advanced tubule-occluding technologies. Methods: A comprehensive narrative review of contemporary literature was conducted, synthesizing data on DH etiology, hydrodynamic theory, iatrogenic factors, behavioral impacts, and pharmacological modalities. Results: Epidemiological reports indicate that DH affects 30% to 67% of adult populations, with peak prevalence in patients aged 40-49 years (84.2%) and those with periodontal disease (up to 98%). The pathophysiology centers on dentin surface “decompensation” - the dissolution of the smear layer and opening of dentinal tubules by acid erosion and abrasion. This triggers a vicious cycle: pain leads to neglected hygiene, accelerating periodontal recession and worsening sensitivity. Conventional therapies, such as potassium salts (nerve depolarization) and high-concentration fluorides, offer limited or delayed efficacy. Conversely, arginine–calcium carbonate technology (PRO-ARGIN™) provides immediate and sustained (over 28 days) tubule occlusion via a physical barrier that mimics natural dentin mineralization. Clinical trials confirm significant reductions in tactile (up to 149.6% superior to control at 4 weeks) and evaporative sensitivity (up to 40.6% superior). Conclusion: Effective management of DH in patients with erosive lesions requires a pathogenetic, personalized strategy. Technology based on arginine and calcium carbonate represents a scientifically sound, clinically proven approach for immediate and durable relief, serving as a primary method of choice in personalized dental rehabilitation protocols.

Maqola ma’lumotlari
MualliflarKhusanbaeva, Jasmin Shavkatovna, Zoirov, Tulqin Elnazarovich
JurnalМактабгача ва мактаб таълими
NashriyotТошкент давлат педагогика университети
ISSN3060-4613, 3060-4613
Nashr sanasi2026-09-25
Jild4
Son9
Betlar99-103
TilIngliz
DOI10.5281/zenodo.23030327
Indeksga qo‘shilgan2026-09-30

DOI: 10.5281/zenodo.23030327 · Maqolaning asl sahifasi

Kalit so‘zlar

Dentin hypersensitivity, acid erosion, pathogenetic therapy, hydrodynamic theory, PRO-ARGIN technology, arginine, calcium carbonate, gingival recession, personalized dentistry

Iqtibos keltirish

APAKhusanbaeva, Jasmin Shavkatovna, & Zoirov, Tulqin Elnazarovich (2026). PATHOGENETIC RATIONALE FOR PERSONALIZED THERAPY OF DENTIN HYPERSENSITIVITY IN PATIENTS WITH EROSIVE TOOTH LESIONS. Мактабгача ва мактаб таълими, 4(9), 99-103. https://doi.org/10.5281/zenodo.23030327
GOST (OAK)Khusanbaeva, Jasmin Shavkatovna, Zoirov, Tulqin Elnazarovich PATHOGENETIC RATIONALE FOR PERSONALIZED THERAPY OF DENTIN HYPERSENSITIVITY IN PATIENTS WITH EROSIVE TOOTH LESIONS // Мактабгача ва мактаб таълими. – 2026. – T. 4, № 9. – P. 99-103. – DOI: 10.5281/zenodo.23030327.
MLAKhusanbaeva, Jasmin Shavkatovna, and Zoirov, Tulqin Elnazarovich. “PATHOGENETIC RATIONALE FOR PERSONALIZED THERAPY OF DENTIN HYPERSENSITIVITY IN PATIENTS WITH EROSIVE TOOTH LESIONS.” Мактабгача ва мактаб таълими, 4(9), 99-103, 2026. https://doi.org/10.5281/zenodo.23030327
ChicagoKhusanbaeva, Jasmin Shavkatovna, and Zoirov, Tulqin Elnazarovich. “PATHOGENETIC RATIONALE FOR PERSONALIZED THERAPY OF DENTIN HYPERSENSITIVITY IN PATIENTS WITH EROSIVE TOOTH LESIONS.” Мактабгача ва мактаб таълими, 4(9), 99-103 (2026). https://doi.org/10.5281/zenodo.23030327
HarvardKhusanbaeva, Jasmin Shavkatovna, and Zoirov, Tulqin Elnazarovich (2026) ‘PATHOGENETIC RATIONALE FOR PERSONALIZED THERAPY OF DENTIN HYPERSENSITIVITY IN PATIENTS WITH EROSIVE TOOTH LESIONS’, Мактабгача ва мактаб таълими, 4(9), 99-103. https://doi.org/10.5281/zenodo.23030327
BibTeX
@article{khusanbaevajasminshavkatovna2026,
  title = {PATHOGENETIC RATIONALE FOR PERSONALIZED THERAPY OF DENTIN HYPERSENSITIVITY IN PATIENTS WITH EROSIVE TOOTH LESIONS},
  author = {Khusanbaeva, Jasmin Shavkatovna and Zoirov, Tulqin Elnazarovich},
  journal = {Мактабгача ва мактаб таълими},
  year = {2026},
  volume = {4},
  number = {9},
  pages = {99-103},
  doi = {10.5281/zenodo.23030327},
  url = {https://doi.org/10.5281/zenodo.23030327}
}

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