Anti-inflammatory and immunomodulatory effects of a combination of hypericum scabrum and calendula officinalis

Askarov, Ibragim R., Turdialiyev , Umid M., Sultonova, Feruza Y.

Товарлар кимёси ва халқ табобати · 2026-yil

Annotatsiya

Inflammation is a complex biological response that plays a critical role in the pathogenesis of many chronic diseases. The search for effective plant-based anti-inflammatory and immunomodulatory agents remains an important area of biomedical research. This study aimed to evaluate the anti-inflammatory and immune-modulating effects of a 3:1 combination of extracts derived from Hypericum scabrum and Calendula officinalis, medicinal plants grown under the conditions of Uzbekistan, in an in vivo experimental model. Experimental investigations were conducted on laboratory mice divided into control and treatment groups (10 animals per group). Inflammation was induced using dextran sulfate sodium administered in drinking water to simulate inflammatory pathology. Beginning on day 7 of the experiment, the treatment group received aqueous extracts of Hypericum scabrum and Calendula officinalis, plants grown under the conditions of Uzbekistan, in a 3:1 ratio, while the control group received standard drinking water. Clinical observations, body weight monitoring, and comprehensive hematological and immunological analyses were performed. Key parameters included total leukocyte count, lymphocytes, neutrophils, monocytes, eosinophils, interleukin-6 (IL-6) concentration, and average body mass. The results demonstrated that dextran sulfate–induced inflammation caused significant leukocytosis, elevated IL-6 levels, and alterations in leukocyte differential counts. Administration of the plant extract combination led to normalization of leukocyte levels, reduction of IL-6 concentration, stabilization of immune cell profiles, and improvement in body weight compared with untreated animals. These findings indicate that the 3:1 combination of Hypericum scabrum and Calendula officinalis, plants grown under the conditions of Uzbekistan, exhibits pronounced anti-inflammatory and immunomodulatory activity in vivo and may serve as a promising natural therapeutic candidate for managing inflammatory disorders.

Maqola ma’lumotlari
MualliflarAskarov, Ibragim R., Turdialiyev , Umid M., Sultonova, Feruza Y.
JurnalТоварлар кимёси ва халқ табобати
NashriyotТабобат академияси
ISSN2181-2977
Nashr sanasi2026-09-11
Jild5
Son3
Betlar330-349
TilIngliz
DOI10.55475/jcgtm/vol5.iss3.2026.673
Indeksga qo‘shilgan2026-09-12

DOI: 10.55475/jcgtm/vol5.iss3.2026.673 · Maqolaning asl sahifasi

Kalit so‘zlar

experimental colitis model, plant-derived bioactive compounds, cytokine regulation, hematological parameters, immune cell modulation, phytopharmacology, natural anti-inflammatory agents, eksperimental kolit modeli, o‘simlik manbali biofaol birikmalar, sitokinlar regulyatsiyasi, gematologik ko‘rsatkichlar, immun hujayralari modulyatsiyasi, fitofarmakologiya, tabiiy yallig‘lanishga qarshi vositalar, экспериментальная модель колита, растительные биоактивные соединения, регуляция цитокинов, гематологические показатели, модуляция иммунных клеток, фитофармакология, природные противовоспалительные средства

Iqtibos keltirish

APAAskarov, Ibragim R., Turdialiyev , Umid M., & Sultonova, Feruza Y. (2026). ANTI-INFLAMMATORY AND IMMUNOMODULATORY EFFECTS OF A COMBINATION OF HYPERICUM SCABRUM AND CALENDULA OFFICINALIS. Товарлар кимёси ва халқ табобати, 5(3), 330-349. https://doi.org/10.55475/jcgtm/vol5.iss3.2026.673
GOST (OAK)Askarov, Ibragim R., Turdialiyev , Umid M., Sultonova, Feruza Y. ANTI-INFLAMMATORY AND IMMUNOMODULATORY EFFECTS OF A COMBINATION OF HYPERICUM SCABRUM AND CALENDULA OFFICINALIS // Товарлар кимёси ва халқ табобати. – 2026. – T. 5, № 3. – P. 330-349. – DOI: 10.55475/jcgtm/vol5.iss3.2026.673.
MLAAskarov, Ibragim R., Turdialiyev , Umid M., and Sultonova, Feruza Y. “ANTI-INFLAMMATORY AND IMMUNOMODULATORY EFFECTS OF A COMBINATION OF HYPERICUM SCABRUM AND CALENDULA OFFICINALIS.” Товарлар кимёси ва халқ табобати, 5(3), 330-349, 2026. https://doi.org/10.55475/jcgtm/vol5.iss3.2026.673
ChicagoAskarov, Ibragim R., Turdialiyev , Umid M., and Sultonova, Feruza Y. “ANTI-INFLAMMATORY AND IMMUNOMODULATORY EFFECTS OF A COMBINATION OF HYPERICUM SCABRUM AND CALENDULA OFFICINALIS.” Товарлар кимёси ва халқ табобати, 5(3), 330-349 (2026). https://doi.org/10.55475/jcgtm/vol5.iss3.2026.673
HarvardAskarov, Ibragim R., Turdialiyev , Umid M., and Sultonova, Feruza Y (2026) ‘ANTI-INFLAMMATORY AND IMMUNOMODULATORY EFFECTS OF A COMBINATION OF HYPERICUM SCABRUM AND CALENDULA OFFICINALIS’, Товарлар кимёси ва халқ табобати, 5(3), 330-349. https://doi.org/10.55475/jcgtm/vol5.iss3.2026.673
BibTeX
@article{askarovibragimr2026,
  title = {ANTI-INFLAMMATORY AND IMMUNOMODULATORY EFFECTS OF A COMBINATION OF HYPERICUM SCABRUM AND CALENDULA OFFICINALIS},
  author = {Askarov, Ibragim R. and Turdialiyev , Umid M. and Sultonova, Feruza Y.},
  journal = {Товарлар кимёси ва халқ табобати},
  year = {2026},
  volume = {5},
  number = {3},
  pages = {330-349},
  doi = {10.55475/jcgtm/vol5.iss3.2026.673},
  url = {https://doi.org/10.55475/jcgtm/vol5.iss3.2026.673}
}

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