The relationship between geometric types of left ventricular remodeling and uromodulin levels in cardiorenal syndrome associated with chronic heart failure

Gadayev A.G, Boboev A.T, Turakulov R.I, Khalilova F.A

Klinik fanlar yilnomasi · 2026-yil

Annotatsiya

The article presents a comprehensive assessment of the relationship between geometric types of left ventricular remodeling and uromodulin levels in cardiorenal syndrome (CRS) associated with chronic heart failure (CHF). The study included 240 participants: Group 1 — with CRS (n=100), Group 2 — CHF without CRS (n=100), Group 3 — control (n=40). In the CRS group, LVMI was 142.5±3.2 g/m² (without CRS: 108.7±2.6; control: 84.3±2.1), relative wall thickness (RWT) — 0.48±0.01. LVH was identified in 90% of CRS patients: eccentric hypertrophy — 55%, concentric hypertrophy — 28%, concentric remodeling — 12%, normal geometry — 5%. Grade III diastolic dysfunction was found in 50% of CRS patients. Uromodulin levels strongly depended on remodeling type: normal geometry — 92.5±3.2 ng/ml, concentric remodeling — 75.3±2.5, concentric hypertrophy — 62.4±1.9, eccentric hypertrophy — 48.6±1.7 ng/ml (p<0.001). A strong inverse correlation was found between uromodulin and LVMI (r=−0.71, p<0.001). 4 figures and 2 tables are presented.

Maqola ma’lumotlari
MualliflarGadayev A.G, Boboev A.T, Turakulov R.I, Khalilova F.A
JurnalKlinik fanlar yilnomasi
NashriyotБухоро давлат тиббиёт институти
ISSN2025-2026, 0009-0006
Nashr sanasi2026-09-09
Jild3
Son2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-09-10

Maqolaning asl sahifasi

Kalit so‘zlar

left ventricular remodeling, concentric hypertrophy, eccentric hypertrophy, relative wall thickness, uromodulin, cardiorenal syndrome, diastolic dysfunction, left ventricular mass index, echocardiography, correlation analysis, ремоделирование левого желудочка, концентрическая гипертрофия, эксцентрическая гипертрофия, относительная толщина стенки, уромодулин, кардиоренальный синдром, диастолическая дисфункция, индекс массы миокарда левого желудочка, эхокардиография, корреляционный анализ, чап қоринча ремоделинги, концентрик гипертрофия, эксцентрик гипертрофия, нисбий девор қалинлиги, уромодулин, кардиоренал синдром, диастолик дисфункция, чап қоринча миокарди индекси, эхокардиография, корреляцион таҳлил

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAGadayev A.G, Boboev A.T, Turakulov R.I, & Khalilova F.A (2026). THE RELATIONSHIP BETWEEN GEOMETRIC TYPES OF LEFT VENTRICULAR REMODELING AND UROMODULIN LEVELS IN CARDIORENAL SYNDROME ASSOCIATED WITH CHRONIC HEART FAILURE. Klinik fanlar yilnomasi, 3(2). https://tadqiqot.uz/index.php/spjacd/article/view/15018
GOST (OAK)Gadayev A.G va b. THE RELATIONSHIP BETWEEN GEOMETRIC TYPES OF LEFT VENTRICULAR REMODELING AND UROMODULIN LEVELS IN CARDIORENAL SYNDROME ASSOCIATED WITH CHRONIC HEART FAILURE // Klinik fanlar yilnomasi. – 2026. – T. 3, № 2.
MLAGadayev A.G, Boboev A.T, Turakulov R.I, and Khalilova F.A. “THE RELATIONSHIP BETWEEN GEOMETRIC TYPES OF LEFT VENTRICULAR REMODELING AND UROMODULIN LEVELS IN CARDIORENAL SYNDROME ASSOCIATED WITH CHRONIC HEART FAILURE.” Klinik fanlar yilnomasi, 3(2), 2026. https://tadqiqot.uz/index.php/spjacd/article/view/15018
ChicagoGadayev A.G, Boboev A.T, Turakulov R.I, and Khalilova F.A. “THE RELATIONSHIP BETWEEN GEOMETRIC TYPES OF LEFT VENTRICULAR REMODELING AND UROMODULIN LEVELS IN CARDIORENAL SYNDROME ASSOCIATED WITH CHRONIC HEART FAILURE.” Klinik fanlar yilnomasi, 3(2) (2026). https://tadqiqot.uz/index.php/spjacd/article/view/15018
HarvardGadayev A.G, Boboev A.T, Turakulov R.I, and Khalilova F.A (2026) ‘THE RELATIONSHIP BETWEEN GEOMETRIC TYPES OF LEFT VENTRICULAR REMODELING AND UROMODULIN LEVELS IN CARDIORENAL SYNDROME ASSOCIATED WITH CHRONIC HEART FAILURE’, Klinik fanlar yilnomasi, 3(2). https://tadqiqot.uz/index.php/spjacd/article/view/15018
BibTeX
@article{gadayevag2026,
  title = {THE RELATIONSHIP BETWEEN GEOMETRIC TYPES OF LEFT VENTRICULAR REMODELING AND UROMODULIN LEVELS IN CARDIORENAL SYNDROME ASSOCIATED WITH CHRONIC HEART FAILURE},
  author = {Gadayev A.G and Boboev A.T and Turakulov R.I and Khalilova F.A},
  journal = {Klinik fanlar yilnomasi},
  year = {2026},
  volume = {3},
  number = {2},
  url = {https://tadqiqot.uz/index.php/spjacd/article/view/15018}
}

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