Neurofilament light chain in ischemic stroke: temporal dynamics, association with disease severity and prognosis (literature review)

Мусаева Юлдуз Алписовна, Ганиева Муаззамхон Жавлон кизи

Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2026-yil

Annotatsiya

Ischemic stroke remains one of the leading causes of death and persistent disability, highlighting the need for objective biomarkers of brain injury and disease prognosis. Neurofilament light chain (NfL) is a structural protein of the axonal cytoskeleton whose concentration increases in response to neuroaxonal damage. The development of highly sensitive methods for detecting NfL in blood has expanded the possibilities for its investigation in ischemic stroke. The aim of this review is to analyze and synthesize current evidence on the temporal dynamics of NfL and its association with ischemic stroke severity, infarct volume, and functional outcomes. Original studies, systematic reviews, and meta-analyses published mainly between 2020 and 2026 were analyzed, with a literature search conducted in the PubMed, Scopus, and Web of Science databases. The reviewed studies indicate that NfL concentrations increase following ischemic stroke and are associated with the severity of neurological deficits. Several studies have also demonstrated an association between NfL levels, infarct volume, and adverse functional outcomes. However, the clinical value of this biomarker depends substantially on the timing of its measurement. According to the largest individual participant data meta-analysis published in 2026, NfL concentrations progressively increased during the first week after stroke, reaching the highest levels approximately on days 6–7. Higher NfL levels, particularly during the subacute period, are associated with unfavorable functional outcomes and an increased risk of mortality. NfL may be considered a promising biomarker of neuroaxonal injury in ischemic stroke; however, its implementation in clinical practice requires standardization of measurement timing and further assessment of its prognostic value in prospective studies.

Maqola ma’lumotlari
MualliflarМусаева Юлдуз Алписовна, Ганиева Муаззамхон Жавлон кизи
JurnalЖурнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research
NashriyotБухоро давлат тиббиёт институти
Nashr sanasi2026-09-07
Jild7
Son5
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-09-08

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Kalit so‘zlar

ишемический инсульт, нейрофиламент легкой цепи, NfL, sNfL, pNfL, нейроаксональное повреждение, биомаркер, тяжесть инсульта, функциональный исход, прогноз, ischemic stroke, neurofilament light chain, NfL, sNfL, pNfL, neuroaxonal injury, biomarker, stroke severity, functional outcome, prognosis, ishemik insult, yengil zanjirli neyrofilament, NfL, sNfL, pNfL, neyroaksonal shikastlanish, biomarker, insult og‘irligi, funksional natija, prognoz

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Iqtibos keltirish

APAМусаева Юлдуз Алписовна, & Ганиева Муаззамхон Жавлон кизи (2026). NEUROFILAMENT LIGHT CHAIN IN ISCHEMIC STROKE: TEMPORAL DYNAMICS, ASSOCIATION WITH DISEASE SEVERITY AND PROGNOSIS (LITERATURE REVIEW). Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 7(5). https://tadqiqot.uz/index.php/neurology/article/view/14979
GOST (OAK)Мусаева Юлдуз Алписовна, Ганиева Муаззамхон Жавлон кизи NEUROFILAMENT LIGHT CHAIN IN ISCHEMIC STROKE: TEMPORAL DYNAMICS, ASSOCIATION WITH DISEASE SEVERITY AND PROGNOSIS (LITERATURE REVIEW) // Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research. – 2026. – T. 7, № 5.
MLAМусаева Юлдуз Алписовна, and Ганиева Муаззамхон Жавлон кизи. “NEUROFILAMENT LIGHT CHAIN IN ISCHEMIC STROKE: TEMPORAL DYNAMICS, ASSOCIATION WITH DISEASE SEVERITY AND PROGNOSIS (LITERATURE REVIEW).” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 7(5), 2026. https://tadqiqot.uz/index.php/neurology/article/view/14979
ChicagoМусаева Юлдуз Алписовна, and Ганиева Муаззамхон Жавлон кизи. “NEUROFILAMENT LIGHT CHAIN IN ISCHEMIC STROKE: TEMPORAL DYNAMICS, ASSOCIATION WITH DISEASE SEVERITY AND PROGNOSIS (LITERATURE REVIEW).” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 7(5) (2026). https://tadqiqot.uz/index.php/neurology/article/view/14979
HarvardМусаева Юлдуз Алписовна, and Ганиева Муаззамхон Жавлон кизи (2026) ‘NEUROFILAMENT LIGHT CHAIN IN ISCHEMIC STROKE: TEMPORAL DYNAMICS, ASSOCIATION WITH DISEASE SEVERITY AND PROGNOSIS (LITERATURE REVIEW)’, Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 7(5). https://tadqiqot.uz/index.php/neurology/article/view/14979
BibTeX
@article{article2026,
  title = {NEUROFILAMENT LIGHT CHAIN IN ISCHEMIC STROKE: TEMPORAL DYNAMICS, ASSOCIATION WITH DISEASE SEVERITY AND PROGNOSIS (LITERATURE REVIEW)},
  author = {Мусаева Юлдуз Алписовна and Ганиева Муаззамхон Жавлон кизи},
  journal = {Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research},
  year = {2026},
  volume = {7},
  number = {5},
  url = {https://tadqiqot.uz/index.php/neurology/article/view/14979}
}

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