Chronic Obstructive Pulmonary Disease: pathophysiology and the role of inflammation

Musayev, Farkhod, Muminov, Davron, Мусаев, Фарход, Муминов, Даврон, Musayev, Farhod, Muminov, Davron

Профилактическая медицина и здоровье · 2024-yil

Annotatsiya

Chronic Obstructive Pulmonary Disease (COPD) is a progressive respiratory condition characterized by persistent airflow limitation and a heightened lung inflammatory response. Systemic inflammation plays a crucial role in COPD pathogenesis, influencing disease progression and the development of comorbidities. This review explores the sequential stages of inflammation-driven pathological changes in COPD, from early airway alterations to advanced systemic effects. The disease process begins with chronic exposure to risk factors such as smoking, air pollution, and occupational hazards. This leads to increased mucus secretion and dysfunction of ciliated epithelial cells, which results in impaired mucociliary clearance and heightened susceptibility to infections. As inflammation persists, bronchial obstruction and airway remodeling occur, limiting airflow. Pulmonary hyperinflation and emphysema further exacerbate respiratory insufficiency by reducing elastic recoil and increasing the work of breathing. Future research should emphasize precision medicine approaches, biomarker identification, and novel anti-inflammatory therapies to mitigate disease progression and enhance patient outcomes.

Maqola ma’lumotlari
MualliflarMusayev, Farkhod, Muminov, Davron, Мусаев, Фарход, Муминов, Даврон, Musayev, Farhod, Muminov, Davron
JurnalПрофилактическая медицина и здоровье
NashriyotАндижон давлат тиббиёт институти; In Science МЧЖ
ISSN2181-3663, 2004-2015
Nashr sanasi2024-10-15
Jild3
Son5
Betlar82-88
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

COPD, systemic inflammation, oxidative stress, airway obstruction, pulmonary hypertension, inflammatory mediators, ХОБЛ, системное воспаление, оксидативный стресс, обструкция дыхательных путей, легочная гипертензия, воспалительные медиаторы, SOOʻK, tizimli yallig‘lanish, oksidlanish stressi, nafas yo‘llarining obstruktsiyasi, o‘pka gipertenziyasi, yallig‘lanish mediatori

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAMusayev, Farkhod, Muminov, Davron, Мусаев, Фарход, Муминов, Даврон, Musayev, Farhod, & Muminov, Davron (2024). Chronic Obstructive Pulmonary Disease: pathophysiology and the role of inflammation. Профилактическая медицина и здоровье, 3(5), 82-88. https://inlibrary.uz/index.php/preventive-medicine/article/view/85173
GOST (OAK)Musayev, Farkhod va b. Chronic Obstructive Pulmonary Disease: pathophysiology and the role of inflammation // Профилактическая медицина и здоровье. – 2024. – T. 3, № 5. – P. 82-88.
MLAMusayev, Farkhod, Muminov, Davron, Мусаев, Фарход, Муминов, Даврон, Musayev, Farhod, and Muminov, Davron. “Chronic Obstructive Pulmonary Disease: pathophysiology and the role of inflammation.” Профилактическая медицина и здоровье, 3(5), 82-88, 2024. https://inlibrary.uz/index.php/preventive-medicine/article/view/85173
ChicagoMusayev, Farkhod, Muminov, Davron, Мусаев, Фарход, Муминов, Даврон, Musayev, Farhod, and Muminov, Davron. “Chronic Obstructive Pulmonary Disease: pathophysiology and the role of inflammation.” Профилактическая медицина и здоровье, 3(5), 82-88 (2024). https://inlibrary.uz/index.php/preventive-medicine/article/view/85173
HarvardMusayev, Farkhod, Muminov, Davron, Мусаев, Фарход, Муминов, Даврон, Musayev, Farhod, and Muminov, Davron (2024) ‘Chronic Obstructive Pulmonary Disease: pathophysiology and the role of inflammation’, Профилактическая медицина и здоровье, 3(5), 82-88. https://inlibrary.uz/index.php/preventive-medicine/article/view/85173
BibTeX
@article{musayevfarkhod2024,
  title = {Chronic Obstructive Pulmonary Disease: pathophysiology and the role of inflammation},
  author = {Musayev, Farkhod and Muminov, Davron and Мусаев, Фарход and Муминов, Даврон and Musayev, Farhod and Muminov, Davron},
  journal = {Профилактическая медицина и здоровье},
  year = {2024},
  volume = {3},
  number = {5},
  pages = {82-88},
  url = {https://inlibrary.uz/index.php/preventive-medicine/article/view/85173}
}

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