Changes of the cytokine profile depending on the severity of endogenous intoxication in mechanical jaundice

Tamara Aripova, N Aripova, S. Matmuradov, Jasurbek Kamilzhanovich Babadzhanov

Shoshilinch tibbiyot axborotnomasi · 2021-yil

Annotatsiya

Aim. Study of the reaction of the cytokine pofil to the severity of the course of endogenous intoxication in patients with obstructive jaundice.Material and methods. The study involved 84 patients with obstructive jaundice (MJ) caused by malignant tumors of the biliopancreatoduodenal zone (BPDZ). There were 55 men (65.5%), women - 29 (34.5%). The average age of the patients was 59.1 ± 2.3 years. The severity of endogenous intoxication and the cytokine profile of patients with breast cancer were assessed by determining the concentration of medium molecular peptides (MMP) and proinflammatory cytokines TNF-α and IL-6 in blood plasma and bile.Conclusion. In patients with breast cancer of tumor genesis, there is a multiple increase in the concentration of proinflammatory cytokines in blood serum and bile. There is also a manifold increase in apoptosis indices of blood lymphocytes and the content of MMP. Adequate and timely decompression of the biliary tract in breast cancer ensures the elimination of factors that cause endogenous intoxication and an increase in the inflammatory process, which makes it possible to prepare the patient for the second stage of radical surgical treatment after of the aplication of a percutaneous-transhepatic cholangiostomy.

Maqola ma’lumotlari
MualliflarTamara Aripova, N Aripova, S. Matmuradov, Jasurbek Kamilzhanovich Babadzhanov
JurnalShoshilinch tibbiyot axborotnomasi
NashriyotЎзбекистон шошилинч тиббий ёрдам врачлари, ассоциацияси
ISSN2010-9881
Nashr sanasi2021-09-20
Jild14
Son3
TilIngliz
Ilmiy sohaTibbiyot
DOI10.54185/tbem/vol14_iss3/a8
Indeksga qo‘shilgan2026-09-02

DOI: 10.54185/tbem/vol14_iss3/a8 · Maqolaning asl sahifasi · PDF

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Iqtibos keltirish

APATamara Aripova, N Aripova, S. Matmuradov, & Jasurbek Kamilzhanovich Babadzhanov (2021). CHANGES OF THE CYTOKINE PROFILE DEPENDING ON THE SEVERITY OF ENDOGENOUS INTOXICATION IN MECHANICAL JAUNDICE. Shoshilinch tibbiyot axborotnomasi, 14(3). https://doi.org/10.54185/tbem/vol14_iss3/a8
GOST (OAK)Tamara Aripova va b. CHANGES OF THE CYTOKINE PROFILE DEPENDING ON THE SEVERITY OF ENDOGENOUS INTOXICATION IN MECHANICAL JAUNDICE // Shoshilinch tibbiyot axborotnomasi. – 2021. – T. 14, № 3. – DOI: 10.54185/tbem/vol14_iss3/a8.
MLATamara Aripova, N Aripova, S. Matmuradov, and Jasurbek Kamilzhanovich Babadzhanov. “CHANGES OF THE CYTOKINE PROFILE DEPENDING ON THE SEVERITY OF ENDOGENOUS INTOXICATION IN MECHANICAL JAUNDICE.” Shoshilinch tibbiyot axborotnomasi, 14(3), 2021. https://doi.org/10.54185/tbem/vol14_iss3/a8
ChicagoTamara Aripova, N Aripova, S. Matmuradov, and Jasurbek Kamilzhanovich Babadzhanov. “CHANGES OF THE CYTOKINE PROFILE DEPENDING ON THE SEVERITY OF ENDOGENOUS INTOXICATION IN MECHANICAL JAUNDICE.” Shoshilinch tibbiyot axborotnomasi, 14(3) (2021). https://doi.org/10.54185/tbem/vol14_iss3/a8
HarvardTamara Aripova, N Aripova, S. Matmuradov, and Jasurbek Kamilzhanovich Babadzhanov (2021) ‘CHANGES OF THE CYTOKINE PROFILE DEPENDING ON THE SEVERITY OF ENDOGENOUS INTOXICATION IN MECHANICAL JAUNDICE’, Shoshilinch tibbiyot axborotnomasi, 14(3). https://doi.org/10.54185/tbem/vol14_iss3/a8
BibTeX
@article{tamaraaripova2021,
  title = {CHANGES OF THE CYTOKINE PROFILE DEPENDING ON THE SEVERITY OF ENDOGENOUS INTOXICATION IN MECHANICAL JAUNDICE},
  author = {Tamara Aripova and N Aripova and S. Matmuradov and Jasurbek Kamilzhanovich Babadzhanov},
  journal = {Shoshilinch tibbiyot axborotnomasi},
  year = {2021},
  volume = {14},
  number = {3},
  doi = {10.54185/tbem/vol14_iss3/a8},
  url = {https://doi.org/10.54185/tbem/vol14_iss3/a8}
}

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