Relevance. The article provides an overview of research on the role of genetic factors in the pathogenesis of age-related macular degeneration. Complement factor H gene Y402H polymorphisms, HTRA1, ARMS2/LOC387715, and PLEKHA1 increase the risk of YMD development. Purpose of the study. A retrospective review of possible patterns of gene mutations influencing the onset and progression of YMD over the past 16 years. Materials and methods. Retrospective study of genes causing the pathogenesis of age-related macular dystrophy in 277 eyes. Result and conclusion. Of particular interest are the disruption of mutations in a number of genes that may halt or reduce the likelihood of developing AMD. In the rapidly developing era, genetic engineering is a promising direction for finding new ways to treat and prevent disease.
| Mualliflar | М. Х. Каримова, З.А. Ходжаева |
|---|---|
| Jurnal | Передовая Офтальмология |
| Nashr sanasi | 2023-05-23 |
| Jild | 3 |
| Son | 3 |
| Betlar | 176-179 |
| Til | ru |
| DOI | 10.57231/j.ao.2023.3.3.041 |
DOI: 10.57231/j.ao.2023.3.3.041 · Maqolaning asl sahifasi · PDF
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