Purpose of this study. The study of the level of brain‑ derived neurotrophic factor (MNF) in lacrimal fluid and blood plasma in Takayasu’s disease and atherosclerosis of the carotid arteries. Material and methods. We examined 28 patients and 10 practically healthy individuals aged 25 to 77 years, the average age was 45±0.5 years. The subjects were divided into 3 groups: group 1–15 patients with a confirmed diagnosis of nonspecific aortoarteritis (Takayasu’s disease); group 2–13 patients diagnosed with atherosclerosis of the carotid arteries; 3rd control group — consisted of 10 practically healthy individuals. All participants in the study underwent general ophthalmological examination methods, determination of the level of MNF in blood plasma and lacrimal fluid was performed by enzyme immunoassay (ELISA). Results. Analyzing the obtained data, it was found that the level of brain‑ derived neurotrophic factor in the blood plasma in the first group averaged 209.2±11.5 pg/ml, while in the second and third groups this figure was 68.2±7.7 pg/ml. ml and 56.4±4.8 pg/ml, respectively. Conclusion.Elevated levels of MNF in tear fluid and blood plasma may be an important early diagnostic sign of Takayasu’s disease.
| Mualliflar | Э. Н. Билалов, К. И. Нарзикулова, Э.М. Миркомилов, О.И. Орипов, Б. Э. Билалов |
|---|---|
| Jurnal | Передовая Офтальмология |
| Nashr sanasi | 2023-02-22 |
| Jild | 1 |
| Son | 1 |
| Betlar | 32-35 |
| Til | ru |
| DOI | 10.57231/j.ao.2023.1.1.007 |
DOI: 10.57231/j.ao.2023.1.1.007 · Maqolaning asl sahifasi · PDF
Relevance. The purpose of the study was to determine the effectiveness of regional lymphatic therapy in patients with diabetes mellitus and myopia of the eye being treated at the endocrinological dispensary of the…
Abstract. Relevance. The results of keratorefractive surgery using Lasik and Femtolasik methods were evaluated inpatients with mild myopia and complex myopic astigmatism. Material and methods. Operations on 20 eyes on…
Relevance. Quality of life, along with other indicators, can comprehensively characterize the effectiveness of the treatment, including for patients with glaucoma. Purpose of the study was to study the quality of life…
Relevance. As a clinical case, an example of a penetrating wound with the presence of a foreign body of the eye was given. The developed step-by-step therapy of a patient with an orbital injury and the presence of an…
Relevance. Central retinal vein occlusion (CRVO) is one of the most common vascular diseases of the eye, potentially leading to complete or partial loss of vision. Purpose of the study. Clinical and functional…
Abstract. Macular hole (MH) is a defect of the neuroretina in the foveal central, which may result in the inadequacy of high acuity vision or in complete vision loss [1]. Traumatic macular hole (TMH) is the second most…
Relevance. Diabetes mellitus (DM) is a chronic systemic disease characterized by the inability of the human body to produce or use sufficient insulin, a hormone that allows cells to absorb glucose from the bloodstream…
Relevance. To evaluate the effectiveness of transscleral laser photocoagulation in micropulse mode and its effect on clinical course of neovascular painful glaucoma. Materials and methods.30 patients (30 eyes) underwent…
Relevance. Burn disease of the eye can be defined as a set of clinical, biochemical, immunological disorders that develop at the local and systemic level from the first days and persist for many years after a severe…
Relevance. The main goal of glaucoma treatment is to lower IOP to a level that prevents or minimizes progressive vision loss. Purpose of the study. To evaluate the antihypertensive efficacy and safety of the fixed…