Association between Tumor Necrosis Factor-α (-238G/A and -308G/A) Gene Polymorphisms and Risk of Ischemic Stroke: A Meta-Analysis

Pradeep Kumar, Shubham Misra, Amit Kumar, Awadh Kishor Pandit, Kamalesh Chakravarty, Kameshwar Prasad

PULSE · 2015-yil

Annotatsiya

Tumor necrosis factor-α (TNF-α) is a proinflammatory pleiotropic cytokine which may contribute to the initiation and progression of ischemic stroke (IS). Thus far, numerous studies have been performed to examine the association between -238G/A (rs361525) and -308G/A (rs1800629) polymorphisms in the promoter regions of the TNF-α gene and susceptibility to IS, but results are still conflicting. The aim of this meta-analysis is to provide a relatively comprehensive account of the association between TNF-α -238G/A and -308G/A gene polymorphisms and susceptibility to IS. A literature search for eligible candidate gene studies published before April 20, 2015, was conducted in the PubMed, Medline, EMBASE and Google Scholar databases. The following combinations of main keywords were used: ('Tumor Necrosis Factor-Alpha' or 'TNF-α') and ('ischemic stroke' or 'cerebral infarction' or 'IS') and ('genetic polymorphism' or 'single nucleotide polymorphisms' or 'SNP'). Fixed- or random-effect models were used to estimate the pooled odds ratio (OR) and 95% confidence interval (CI). Meta-analysis was carried out by using RevMan 5.3 software. For TNF-α -238G/A gene polymorphism, 7 case-control studies with a total of 1,846 IS patients and 1,905 controls showed a significant association with susceptibility to IS under a dominant model (AA + GA vs. GG; OR, 1.40; 95% CI, 1.11-1.76; p value 0.004). For TNF-α -308G/A gene polymorphism, 16 case-control studies with a total of 5,651 IS patients and 5,792 controls showed a significant protective association with susceptibility to IS under a dominant model (AA + GA vs. GG; OR, 0.78, 95% CI, 0.63-0.97; p value 0.03). Our meta-analysis shows that TNF-α -238G/A gene polymorphism is more likely to be associated with the risk of IS in Caucasian populations as compared to Asian populations. However, TNF-α -308G/A gene polymorphism is more likely to be protective against IS in Asian populations as compared to Caucasian populations. Further large, well-designed prospective epidemiological studies are needed to confirm these findings.

Maqola ma’lumotlari
MualliflarPradeep Kumar, Shubham Misra, Amit Kumar, Awadh Kishor Pandit, Kamalesh Chakravarty, Kameshwar Prasad
JurnalPULSE
NashriyotPROFI университетининг
ISSN2074-1855, 2235-8668
Nashr sanasi2015-01-01
Jild3
Son3-4
Betlar217-228
TilIngliz
Ilmiy sohaPsixologiya
DOI10.1159/000443770
Indeksga qo‘shilgan2026-09-02

DOI: 10.1159/000443770 · Maqolaning asl sahifasi

Ilmiy soha

Psixologiya

Iqtibos keltirish

APAPradeep Kumar, Shubham Misra, Amit Kumar, Awadh Kishor Pandit, Kamalesh Chakravarty, & Kameshwar Prasad (2015). Association between Tumor Necrosis Factor-α (-238G/A and -308G/A) Gene Polymorphisms and Risk of Ischemic Stroke: A Meta-Analysis. PULSE, 3(3-4), 217-228. https://doi.org/10.1159/000443770
GOST (OAK)Pradeep Kumar va b. Association between Tumor Necrosis Factor-α (-238G/A and -308G/A) Gene Polymorphisms and Risk of Ischemic Stroke: A Meta-Analysis // PULSE. – 2015. – T. 3, № 3-4. – P. 217-228. – DOI: 10.1159/000443770.
MLAPradeep Kumar, Shubham Misra, Amit Kumar, Awadh Kishor Pandit, Kamalesh Chakravarty, and Kameshwar Prasad. “Association between Tumor Necrosis Factor-α (-238G/A and -308G/A) Gene Polymorphisms and Risk of Ischemic Stroke: A Meta-Analysis.” PULSE, 3(3-4), 217-228, 2015. https://doi.org/10.1159/000443770
ChicagoPradeep Kumar, Shubham Misra, Amit Kumar, Awadh Kishor Pandit, Kamalesh Chakravarty, and Kameshwar Prasad. “Association between Tumor Necrosis Factor-α (-238G/A and -308G/A) Gene Polymorphisms and Risk of Ischemic Stroke: A Meta-Analysis.” PULSE, 3(3-4), 217-228 (2015). https://doi.org/10.1159/000443770
HarvardPradeep Kumar, Shubham Misra, Amit Kumar, Awadh Kishor Pandit, Kamalesh Chakravarty, and Kameshwar Prasad (2015) ‘Association between Tumor Necrosis Factor-α (-238G/A and -308G/A) Gene Polymorphisms and Risk of Ischemic Stroke: A Meta-Analysis’, PULSE, 3(3-4), 217-228. https://doi.org/10.1159/000443770
BibTeX
@article{pradeepkumar2015,
  title = {Association between Tumor Necrosis Factor-α (-238G/A and -308G/A) Gene Polymorphisms and Risk of Ischemic Stroke: A Meta-Analysis},
  author = {Pradeep Kumar and Shubham Misra and Amit Kumar and Awadh Kishor Pandit and Kamalesh Chakravarty and Kameshwar Prasad},
  journal = {PULSE},
  year = {2015},
  volume = {3},
  number = {3-4},
  pages = {217-228},
  doi = {10.1159/000443770},
  url = {https://doi.org/10.1159/000443770}
}

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