Vitamin-K-Dependent Protection of the Renal Microvasculature: Histopathological Studies in Normal and Diseased Kidneys

Fang‐Fei Wei, Nadja E.A. Drummen, Lutgarde Thijs, Lotte Jacobs, Marjolein Herfs, Cynthia van''t Hoofd, Cees Vermeer, Jan A. Staessen

PULSE · 2016-yil

Annotatsiya

Vitamin-K-dependent carboxylation of matrix Gla protein (MGP) protects the macrocirculation against calcification. We recently reported in a multiethnic population study that the estimated glomerular filtration rate, a microvascular trait, decreased and the risk of chronic kidney disease increased with higher circulating levels of inactive dephospho-uncarboxylated MGP, a marker of vitamin K deficiency. These findings highlighted the possibility that vitamin K might have a beneficial effect on the renal microcirculation. To substantiate these epidemiological findings, we undertook a pilot study, in which we stained renal tissue samples obtained by biopsy from 2 healthy kidney donors and 4 patients with nephropathy for carboxylated and uncarboxylated MGP and calcium deposits. Three patients had renal calcifications, which were consistently associated with carboxylated and uncarboxylated MGP. Normal renal tissue was devoid of microcalcifications and staining for carboxylated and uncarboxylated MGP. Pending confirmation in a larger study covering a wider range of renal pathologies, these histopathological findings suggest that MGP might inhibit calcification not only in large arteries, as was known before, but in renal tissue as well, thereby highlighting potentially new avenues for promoting renal health, for instance by vitamin K supplementation.

Maqola ma’lumotlari
MualliflarFang‐Fei Wei, Nadja E.A. Drummen, Lutgarde Thijs, Lotte Jacobs, Marjolein Herfs, Cynthia van''t Hoofd, Cees Vermeer, Jan A. Staessen
JurnalPULSE
NashriyotPROFI университетининг
ISSN2074-1855, 2235-8668
Nashr sanasi2016-01-01
Jild4
Son2-3
Betlar85-91
TilIngliz
Ilmiy sohaPsixologiya
DOI10.1159/000448008
Indeksga qo‘shilgan2026-09-02

DOI: 10.1159/000448008 · Maqolaning asl sahifasi · PDF

Ilmiy soha

Psixologiya

Iqtibos keltirish

APAFang‐Fei Wei, Nadja E.A. Drummen, Lutgarde Thijs, Lotte Jacobs, Marjolein Herfs, Cynthia van''t Hoofd, Cees Vermeer, & Jan A. Staessen (2016). Vitamin-K-Dependent Protection of the Renal Microvasculature: Histopathological Studies in Normal and Diseased Kidneys. PULSE, 4(2-3), 85-91. https://doi.org/10.1159/000448008
GOST (OAK)Fang‐Fei Wei va b. Vitamin-K-Dependent Protection of the Renal Microvasculature: Histopathological Studies in Normal and Diseased Kidneys // PULSE. – 2016. – T. 4, № 2-3. – P. 85-91. – DOI: 10.1159/000448008.
MLAFang‐Fei Wei, Nadja E.A. Drummen, Lutgarde Thijs, Lotte Jacobs, Marjolein Herfs, Cynthia van''t Hoofd, Cees Vermeer, and Jan A. Staessen. “Vitamin-K-Dependent Protection of the Renal Microvasculature: Histopathological Studies in Normal and Diseased Kidneys.” PULSE, 4(2-3), 85-91, 2016. https://doi.org/10.1159/000448008
ChicagoFang‐Fei Wei, Nadja E.A. Drummen, Lutgarde Thijs, Lotte Jacobs, Marjolein Herfs, Cynthia van''t Hoofd, Cees Vermeer, and Jan A. Staessen. “Vitamin-K-Dependent Protection of the Renal Microvasculature: Histopathological Studies in Normal and Diseased Kidneys.” PULSE, 4(2-3), 85-91 (2016). https://doi.org/10.1159/000448008
HarvardFang‐Fei Wei, Nadja E.A. Drummen, Lutgarde Thijs, Lotte Jacobs, Marjolein Herfs, Cynthia van''t Hoofd, Cees Vermeer, and Jan A. Staessen (2016) ‘Vitamin-K-Dependent Protection of the Renal Microvasculature: Histopathological Studies in Normal and Diseased Kidneys’, PULSE, 4(2-3), 85-91. https://doi.org/10.1159/000448008
BibTeX
@article{fangfeiwei2016,
  title = {Vitamin-K-Dependent Protection of the Renal Microvasculature: Histopathological Studies in Normal and Diseased Kidneys},
  author = {Fang‐Fei Wei and Nadja E.A. Drummen and Lutgarde Thijs and Lotte Jacobs and Marjolein Herfs and Cynthia van''t Hoofd and Cees Vermeer and Jan A. Staessen},
  journal = {PULSE},
  year = {2016},
  volume = {4},
  number = {2-3},
  pages = {85-91},
  doi = {10.1159/000448008},
  url = {https://doi.org/10.1159/000448008}
}

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