A Comparative Study on Skin and Plasma Advanced Glycation End Products and Their Associations with Arterial Stiffness

Changyuan Liu, Qi‐Fang Huang, Yi‐Bang Cheng, Qian‐Hui Guo, Qi Chen, Yan Li, Ji‐Guang Wang

PULSE · 2016-yil

Annotatsiya

Background: We compared skin and plasma measurements of advanced glycation end products (AGEs), with particular focus on their levels in the presence of hypertension or diabetes and prediabetes and their associations with arterial stiffness in outpatients with suspected or diagnosed hypertension. Methods: Skin AGE accumulation was measured as autofluorescence on the left forearm using the skin autofluorescence Reader and expressed in arbitrary units in the range from 0 to 25. Plasma AGE concentration was measured by the enzyme-linked immunosorbent assay method and logarithmically transformed for statistical analysis. Arterial stiffness was assessed by carotid-femoral pulse wave velocity (cfPWV) using the SphygmoCor system (Sydney, Australia). Results: The 218 participants (96 [44.0%] men, mean age 51.9 years) had a mean skin autofluorescence of 1.89 arbitrary units, plasma AGE concentration of 4.47 μg/ml, and cfPWV of 8.0 m/s. Skin autofluorescence was significantly correlated with plasma AGEs in diabetic or prediabetic patients (n = 31, r = 0.37, p = 0.04) but not in subjects with normoglycemia (n = 187, r = -0.05, p = 0.48). Nonetheless, both measurements were significantly (p ≤ 0.001) higher in men (2.00 arbitrary units and 6.73 μg/ml, respectively) than women (1.81 arbitrary units and 3.60 μg/ml, respectively) and in diabetic or prediabetic (2.03 arbitrary units and 6.61 μg/ml, respectively) than normoglycemia subjects (1.87 arbitrary units and 4.17 μg/ml, respectively), but similar in hypertensive (n = 105) and normotensive subjects (n = 113, p ≥ 0.35). In adjusted multiple regression analyses, plasma AGE concentration, but not skin autofluorescence (p ≥ 0.37), was significantly associated with cfPWV in all subjects (β 0.44 m/s for each 10-fold increase; p = 0.04) and in subgroups of men and diabetes and prediabetes (β 0.12-0.55 m/s for each 10-fold increase; p ≤ 0.02). Conclusions: Although skin and plasma AGEs were similarly associated with gender and diabetes or prediabetes, they might measure something different and have different clinical relevance, such as for arterial stiffness.

Maqola ma’lumotlari
MualliflarChangyuan Liu, Qi‐Fang Huang, Yi‐Bang Cheng, Qian‐Hui Guo, Qi Chen, Yan Li, Ji‐Guang Wang
JurnalPULSE
NashriyotPROFI университетининг
ISSN2074-1855, 2235-8668
Nashr sanasi2016-01-01
Jild4
Son4
Betlar208-218
TilIngliz
Ilmiy sohaPsixologiya
DOI10.1159/000453581
Indeksga qo‘shilgan2026-09-02

DOI: 10.1159/000453581 · Maqolaning asl sahifasi · PDF

Ilmiy soha

Psixologiya

Iqtibos keltirish

APAChangyuan Liu, Qi‐Fang Huang, Yi‐Bang Cheng, Qian‐Hui Guo, Qi Chen, Yan Li, & Ji‐Guang Wang (2016). A Comparative Study on Skin and Plasma Advanced Glycation End Products and Their Associations with Arterial Stiffness. PULSE, 4(4), 208-218. https://doi.org/10.1159/000453581
GOST (OAK)Changyuan Liu va b. A Comparative Study on Skin and Plasma Advanced Glycation End Products and Their Associations with Arterial Stiffness // PULSE. – 2016. – T. 4, № 4. – P. 208-218. – DOI: 10.1159/000453581.
MLAChangyuan Liu, Qi‐Fang Huang, Yi‐Bang Cheng, Qian‐Hui Guo, Qi Chen, Yan Li, and Ji‐Guang Wang. “A Comparative Study on Skin and Plasma Advanced Glycation End Products and Their Associations with Arterial Stiffness.” PULSE, 4(4), 208-218, 2016. https://doi.org/10.1159/000453581
ChicagoChangyuan Liu, Qi‐Fang Huang, Yi‐Bang Cheng, Qian‐Hui Guo, Qi Chen, Yan Li, and Ji‐Guang Wang. “A Comparative Study on Skin and Plasma Advanced Glycation End Products and Their Associations with Arterial Stiffness.” PULSE, 4(4), 208-218 (2016). https://doi.org/10.1159/000453581
HarvardChangyuan Liu, Qi‐Fang Huang, Yi‐Bang Cheng, Qian‐Hui Guo, Qi Chen, Yan Li, and Ji‐Guang Wang (2016) ‘A Comparative Study on Skin and Plasma Advanced Glycation End Products and Their Associations with Arterial Stiffness’, PULSE, 4(4), 208-218. https://doi.org/10.1159/000453581
BibTeX
@article{changyuanliu2016,
  title = {A Comparative Study on Skin and Plasma Advanced Glycation End Products and Their Associations with Arterial Stiffness},
  author = {Changyuan Liu and Qi‐Fang Huang and Yi‐Bang Cheng and Qian‐Hui Guo and Qi Chen and Yan Li and Ji‐Guang Wang},
  journal = {PULSE},
  year = {2016},
  volume = {4},
  number = {4},
  pages = {208-218},
  doi = {10.1159/000453581},
  url = {https://doi.org/10.1159/000453581}
}

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