A quantitative structure-activity relationship (qsar) study of the hepatoprotective activity of iridoids

Durbek Usmanov, В. Н. Сыров, Nurmurod Sheralievich Ramazonov

Илм-фан ва инновацион ривожланиш · 2020-yil

Annotatsiya

This study is devoted to the investigation of 10 iridoids applying quantitative structure-activity relationship analysis (QSAR) to correlate and predict their hepatoprotective activity. Iridoids, the largest class of monoterpenoids, are widespread group of substances occurring in various plant organisms. Quantum-chemical descriptors were calculated by the semi-empirical RM1 approach. The obtained model is useful for the description of iridoids hepatoprotective activity and can be used to estimate the hepatoprotective activity of new substituted iridoids. The model obtained in our study shows not only statistical significance, but also an excellent predictive ability. The estimated predictive ability (r 2 test) of the model for the external set is 0.99.

Maqola ma’lumotlari
MualliflarDurbek Usmanov, В. Н. Сыров, Nurmurod Sheralievich Ramazonov
JurnalИлм-фан ва инновацион ривожланиш
NashriyotИнновацион ривожланиш вазирлиги
ISSN2181-9637, 2181-4317
Nashr sanasi2020-09-10
Jild3
Son4
Betlar159-165
TilIngliz
DOI10.36522/2181-9637-2020-4-16
Indeksga qo‘shilgan2026-09-02

DOI: 10.36522/2181-9637-2020-4-16 · Maqolaning asl sahifasi · PDF

Iqtibos keltirish

APADurbek Usmanov, В. Н. Сыров, & Nurmurod Sheralievich Ramazonov (2020). A QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP (QSAR) STUDY OF THE HEPATOPROTECTIVE ACTIVITY OF IRIDOIDS. Илм-фан ва инновацион ривожланиш, 3(4), 159-165. https://doi.org/10.36522/2181-9637-2020-4-16
GOST (OAK)Durbek Usmanov, В. Н. Сыров, Nurmurod Sheralievich Ramazonov A QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP (QSAR) STUDY OF THE HEPATOPROTECTIVE ACTIVITY OF IRIDOIDS // Илм-фан ва инновацион ривожланиш. – 2020. – T. 3, № 4. – P. 159-165. – DOI: 10.36522/2181-9637-2020-4-16.
MLADurbek Usmanov, В. Н. Сыров, and Nurmurod Sheralievich Ramazonov. “A QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP (QSAR) STUDY OF THE HEPATOPROTECTIVE ACTIVITY OF IRIDOIDS.” Илм-фан ва инновацион ривожланиш, 3(4), 159-165, 2020. https://doi.org/10.36522/2181-9637-2020-4-16
ChicagoDurbek Usmanov, В. Н. Сыров, and Nurmurod Sheralievich Ramazonov. “A QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP (QSAR) STUDY OF THE HEPATOPROTECTIVE ACTIVITY OF IRIDOIDS.” Илм-фан ва инновацион ривожланиш, 3(4), 159-165 (2020). https://doi.org/10.36522/2181-9637-2020-4-16
HarvardDurbek Usmanov, В. Н. Сыров, and Nurmurod Sheralievich Ramazonov (2020) ‘A QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP (QSAR) STUDY OF THE HEPATOPROTECTIVE ACTIVITY OF IRIDOIDS’, Илм-фан ва инновацион ривожланиш, 3(4), 159-165. https://doi.org/10.36522/2181-9637-2020-4-16
BibTeX
@article{durbekusmanov2020,
  title = {A QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP (QSAR) STUDY OF THE HEPATOPROTECTIVE ACTIVITY OF IRIDOIDS},
  author = {Durbek Usmanov and В. Н. Сыров and Nurmurod Sheralievich Ramazonov},
  journal = {Илм-фан ва инновацион ривожланиш},
  year = {2020},
  volume = {3},
  number = {4},
  pages = {159-165},
  doi = {10.36522/2181-9637-2020-4-16},
  url = {https://doi.org/10.36522/2181-9637-2020-4-16}
}

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