While the hepatotoxicity of anti-tuberculosis therapy is well-documented, its direct impact on liver fibrogenesis requires clarification. The aim of this study was to comparatively evaluate the levels of key markers of liver fibrogenesis—collagen types I and IV—in 30 tuberculosis patients without viral hepatitis before and after standard treatment. Serum levels of collagen types I and IV were assessed by ELISA after the 2-month intensive phase of therapy. The results demonstrated a statistically significant increase in the concentration of both collagen types during treatment (p<0.001). These findings indicate that anti-tuberculosis drugs not only cause hepatocyte injury but also activate the initial stages of fibrous tissue formation in the liver. Collagen types I and IV may serve as sensitive non-invasive markers for assessing the fibrogenic potential of anti-tuberculosis therapy and for the early diagnosis of drug-induced liver injury.
| Mualliflar | Yitmasova Tuhfa Davlatovna, Obloqulov Abdurashid Raximovich, Usmonov Isomiddin Khaidarovich |
|---|---|
| Jurnal | Klinik fanlar yilnomasi |
| Nashr sanasi | 2025-11-12 |
| Jild | 2 |
| Son | 3/2 |
| Til | O‘zbek |
tuberculosis, drug-induced liver injury (DILI), hepatotoxicity, liver fibrosis, collagen type I, collagen type IV, fibrogenesis, non-invasive diagnostics, туберкулез, лекарственное поражение печени, гепатотоксичность, фиброз печени, коллаген I, коллаген IV, фиброгенез, неинвазивная диагностика, сил, доридан жигар шикастланиши, гепатотоксиклик, жигар фибрози, коллаген I, коллаген IV, фиброгенез, ноинвазив диагностика
The involvement of melatonin levels in the development of severe epilepsy, insomnia and deterioration in quality of life with diagnostically significant melatonin levels >55 pg/ml is scientifically substantiated. The…
In recent studies, obesity has been associated with a decrease in microbial diversity and a decrease in the species richness of the microbiota. A study was conducted where two groups were included: the main group - 60…
For several thousand years, various methods of surgical treatment of congenital cleft lip and palate have been used. But despite this, the treatment of these pathologies is still a difficult task for surgeons. In this…
This study was performed on the basis of the coloproctology department of the Republican Medical Specialized Scientific and Practical Center of Oncology and Radiology in Tashkent. Locally advanced colon and rectosigmoid…
The optimal cut-off points for satiety and fasting were 145 mg/dl and 110 mg/dl, with C-statistics of 0.594 and 0.626, Youden index of 0.187 and 0.252, and Harrell's fit statistic of 0.590 and 0.630. The corresponding…
Arterial hypertension is one of the most common and fatal diseases in the world, including in our republic. When chronic obstructive pulmonary disease is accompanied by arterial hypertension and is accompanied by renal…
This article explores the effects of hormonal changes on oral health in women of reproductive age preparing for pregnancy. Fluctuations in estrogen and progesterone levels can significantly affect the oral mucosa…
Febrile seizures are generalized seizures, usually in children between the ages of 6 months and 5 years. Despite the relatively favorable prognosis, FS often causes significant anxiety among parents and may be…
Secondary cataract (secondary clouding of the posterior lens capsule) is a frequent complication after surgical treatment of cataracts in children. Nd:YAG laser capsulotomy (Nd:YAG-LC) has proven itself as an effective…
This review article summarizes current data on the role of gut microbiota in the development of neurological disorders in children. It discusses the formation and age-specific dynamics of gut microbiota, its…