Dynamics of liver fibrogenesis markers in patients with tuberculosis without viral hepatitis within the front of treatment

Yitmasova Tuhfa Davlatovna, Obloqulov Abdurashid Raximovich, Usmonov Isomiddin Khaidarovich

Klinik fanlar yilnomasi · 2025-yil

Annotatsiya

While the hepatotoxicity of anti-tuberculosis therapy is well-documented, its direct impact on liver fibrogenesis requires clarification. The aim of this study was to comparatively evaluate the levels of key markers of liver fibrogenesis—collagen types I and IV—in 30 tuberculosis patients without viral hepatitis before and after standard treatment. Serum levels of collagen types I and IV were assessed by ELISA after the 2-month intensive phase of therapy. The results demonstrated a statistically significant increase in the concentration of both collagen types during treatment (p<0.001). These findings indicate that anti-tuberculosis drugs not only cause hepatocyte injury but also activate the initial stages of fibrous tissue formation in the liver. Collagen types I and IV may serve as sensitive non-invasive markers for assessing the fibrogenic potential of anti-tuberculosis therapy and for the early diagnosis of drug-induced liver injury.

Maqola ma’lumotlari
MualliflarYitmasova Tuhfa Davlatovna, Obloqulov Abdurashid Raximovich, Usmonov Isomiddin Khaidarovich
JurnalKlinik fanlar yilnomasi
NashriyotБухоро давлат тиббиёт институти
ISSN2025-2026, 0009-0006
Nashr sanasi2025-11-12
Jild2
Son3/2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

tuberculosis, drug-induced liver injury (DILI), hepatotoxicity, liver fibrosis, collagen type I, collagen type IV, fibrogenesis, non-invasive diagnostics, туберкулез, лекарственное поражение печени, гепатотоксичность, фиброз печени, коллаген I, коллаген IV, фиброгенез, неинвазивная диагностика, сил, доридан жигар шикастланиши, гепатотоксиклик, жигар фибрози, коллаген I, коллаген IV, фиброгенез, ноинвазив диагностика

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAYitmasova Tuhfa Davlatovna, Obloqulov Abdurashid Raximovich, & Usmonov Isomiddin Khaidarovich (2025). DYNAMICS OF LIVER FIBROGENESIS MARKERS IN PATIENTS WITH TUBERCULOSIS WITHOUT VIRAL HEPATITIS WITHIN THE FRONT OF TREATMENT. Klinik fanlar yilnomasi, 2(3/2). https://tadqiqot.uz/index.php/spjacd/article/view/12847
GOST (OAK)Yitmasova Tuhfa Davlatovna, Obloqulov Abdurashid Raximovich, Usmonov Isomiddin Khaidarovich DYNAMICS OF LIVER FIBROGENESIS MARKERS IN PATIENTS WITH TUBERCULOSIS WITHOUT VIRAL HEPATITIS WITHIN THE FRONT OF TREATMENT // Klinik fanlar yilnomasi. – 2025. – T. 2, № 3/2.
MLAYitmasova Tuhfa Davlatovna, Obloqulov Abdurashid Raximovich, and Usmonov Isomiddin Khaidarovich. “DYNAMICS OF LIVER FIBROGENESIS MARKERS IN PATIENTS WITH TUBERCULOSIS WITHOUT VIRAL HEPATITIS WITHIN THE FRONT OF TREATMENT.” Klinik fanlar yilnomasi, 2(3/2), 2025. https://tadqiqot.uz/index.php/spjacd/article/view/12847
ChicagoYitmasova Tuhfa Davlatovna, Obloqulov Abdurashid Raximovich, and Usmonov Isomiddin Khaidarovich. “DYNAMICS OF LIVER FIBROGENESIS MARKERS IN PATIENTS WITH TUBERCULOSIS WITHOUT VIRAL HEPATITIS WITHIN THE FRONT OF TREATMENT.” Klinik fanlar yilnomasi, 2(3/2) (2025). https://tadqiqot.uz/index.php/spjacd/article/view/12847
HarvardYitmasova Tuhfa Davlatovna, Obloqulov Abdurashid Raximovich, and Usmonov Isomiddin Khaidarovich (2025) ‘DYNAMICS OF LIVER FIBROGENESIS MARKERS IN PATIENTS WITH TUBERCULOSIS WITHOUT VIRAL HEPATITIS WITHIN THE FRONT OF TREATMENT’, Klinik fanlar yilnomasi, 2(3/2). https://tadqiqot.uz/index.php/spjacd/article/view/12847
BibTeX
@article{yitmasovatuhfadavlatovna2025,
  title = {DYNAMICS OF LIVER FIBROGENESIS MARKERS IN PATIENTS WITH TUBERCULOSIS WITHOUT VIRAL HEPATITIS WITHIN THE FRONT OF TREATMENT},
  author = {Yitmasova Tuhfa Davlatovna and Obloqulov Abdurashid Raximovich and Usmonov Isomiddin Khaidarovich},
  journal = {Klinik fanlar yilnomasi},
  year = {2025},
  volume = {2},
  number = {3/2},
  url = {https://tadqiqot.uz/index.php/spjacd/article/view/12847}
}

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