Developmental and epileptic encephalopathies with spike–wave activation in sleep (DEE-SWAS, formerly known as CSWS/ESES) represent a severe form of epilepsy characterized by neurodevelopmental regression, behavioral disturbances, speech impairment, and cognitive deficits. The key neurophysiological hallmark of the syndrome is pronounced epileptiform activity during slow-wave sleep with a high spike–wave index (SWI). Higher SWI values correlate with more severe clinical regression, and the duration of untreated sleep-activated epileptiform activity is directly associated with cognitive decline. To date, hormonal therapy (corticosteroids or ACTH) is considered the most effective treatment option; however, optimal treatment regimens and therapeutic combinations require further investigation. Clobazam, a benzodiazepine anticonvulsant with proven efficacy in DEE-SWAS, is frequently used as part of polytherapy. Nevertheless, data on combined treatment with hormonal therapy and clobazam in Central Asian populations are scarce.
| Mualliflar | Шохимардонов Шохижахон Шохимардонович, Туйчибаева Нодира Мираталиевна |
|---|---|
| Jurnal | Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research |
| Nashr sanasi | 2026-01-05 |
| Jild | 6 |
| Son | 6/2 |
| Til | Rus |
DEE-SWAS, Эпилептическая энцефалопатия, Эпилепсия, Гормональная терапия, Клобазам, DEE-SWAS, epileptic encephalopathy, epilepsy, hormonal therapy, clobazam, DEE-SWAS, epileptic encephalopathy, epilepsy, hormonal therapy, clobazam
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