Outcomes in patients with dee-swas treated with hormonal therapy in combination with clobazam: prospective study data

Шохимардонов Шохижахон Шохимардонович, Туйчибаева Нодира Мираталиевна

Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2026-yil

Annotatsiya

Developmental and epileptic encephalopathies with spike–wave activation in sleep (DEE-SWAS, formerly known as CSWS/ESES) represent a severe form of epilepsy characterized by neurodevelopmental regression, behavioral disturbances, speech impairment, and cognitive deficits. The key neurophysiological hallmark of the syndrome is pronounced epileptiform activity during slow-wave sleep with a high spike–wave index (SWI). Higher SWI values correlate with more severe clinical regression, and the duration of untreated sleep-activated epileptiform activity is directly associated with cognitive decline. To date, hormonal therapy (corticosteroids or ACTH) is considered the most effective treatment option; however, optimal treatment regimens and therapeutic combinations require further investigation. Clobazam, a benzodiazepine anticonvulsant with proven efficacy in DEE-SWAS, is frequently used as part of polytherapy. Nevertheless, data on combined treatment with hormonal therapy and clobazam in Central Asian populations are scarce.

Maqola ma’lumotlari
MualliflarШохимардонов Шохижахон Шохимардонович, Туйчибаева Нодира Мираталиевна
JurnalЖурнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research
NashriyotБухоро давлат тиббиёт институти
Nashr sanasi2026-01-05
Jild6
Son6/2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

DEE-SWAS, Эпилептическая энцефалопатия, Эпилепсия, Гормональная терапия, Клобазам, DEE-SWAS, epileptic encephalopathy, epilepsy, hormonal therapy, clobazam, DEE-SWAS, epileptic encephalopathy, epilepsy, hormonal therapy, clobazam

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAШохимардонов Шохижахон Шохимардонович, & Туйчибаева Нодира Мираталиевна (2026). OUTCOMES IN PATIENTS WITH DEE-SWAS TREATED WITH HORMONAL THERAPY IN COMBINATION WITH CLOBAZAM: PROSPECTIVE STUDY DATA. Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(6/2). https://tadqiqot.uz/index.php/neurology/article/view/13089
GOST (OAK)Шохимардонов Шохижахон Шохимардонович, Туйчибаева Нодира Мираталиевна OUTCOMES IN PATIENTS WITH DEE-SWAS TREATED WITH HORMONAL THERAPY IN COMBINATION WITH CLOBAZAM: PROSPECTIVE STUDY DATA // Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research. – 2026. – T. 6, № 6/2.
MLAШохимардонов Шохижахон Шохимардонович, and Туйчибаева Нодира Мираталиевна. “OUTCOMES IN PATIENTS WITH DEE-SWAS TREATED WITH HORMONAL THERAPY IN COMBINATION WITH CLOBAZAM: PROSPECTIVE STUDY DATA.” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(6/2), 2026. https://tadqiqot.uz/index.php/neurology/article/view/13089
ChicagoШохимардонов Шохижахон Шохимардонович, and Туйчибаева Нодира Мираталиевна. “OUTCOMES IN PATIENTS WITH DEE-SWAS TREATED WITH HORMONAL THERAPY IN COMBINATION WITH CLOBAZAM: PROSPECTIVE STUDY DATA.” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(6/2) (2026). https://tadqiqot.uz/index.php/neurology/article/view/13089
HarvardШохимардонов Шохижахон Шохимардонович, and Туйчибаева Нодира Мираталиевна (2026) ‘OUTCOMES IN PATIENTS WITH DEE-SWAS TREATED WITH HORMONAL THERAPY IN COMBINATION WITH CLOBAZAM: PROSPECTIVE STUDY DATA’, Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(6/2). https://tadqiqot.uz/index.php/neurology/article/view/13089
BibTeX
@article{article2026,
  title = {OUTCOMES IN PATIENTS WITH DEE-SWAS TREATED WITH HORMONAL THERAPY IN COMBINATION WITH CLOBAZAM: PROSPECTIVE STUDY DATA},
  author = {Шохимардонов Шохижахон Шохимардонович and Туйчибаева Нодира Мираталиевна},
  journal = {Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research},
  year = {2026},
  volume = {6},
  number = {6/2},
  url = {https://tadqiqot.uz/index.php/neurology/article/view/13089}
}

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