Preeclampsia (PE) remains one of the leading causes of maternal and perinatal morbidity and mortality. The key mechanism of its pathogenesis is endothelial dysfunction associated with an imbalance between pro- and anti-angiogenic factors. The most studied markers include sFlt-1, PlGF, VEGF, and endothelin-1, whose alterations reflect the degree of vascular impairment. Particular attention is given to the neurological complications of PE, including eclampsia, stroke, posterior reversible encephalopathy syndrome, cognitive and psycho-emotional disorders. Their development is associated with disruption of the blood-brain barrier, vasospasm, and neuronal damage. In recent years, neuronal biomarkers such as GFAP and NfL have been investigated, allowing the detection of glial and axonal injury. A comprehensive assessment of endothelial and neuronal markers opens new perspectives for early diagnosis, prognosis, and personalized management of patients with PE.
| Mualliflar | Рахматуллаева Гулнара Кутбитдиновна, Худаярова Севара Муратбековна |
|---|---|
| Jurnal | Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research |
| Nashr sanasi | 2025-10-14 |
| Jild | 6 |
| Son | 6 |
| Til | Rus |
эндотелиальная дисфункция, биомаркеры, неврологические осложнения, endothelial dysfunction, biomarkers, neurological complications, эндотелиал дисфункция, биомаркерлар, неврологик асоратлар
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