CORRECTION OF MITOCHONDRIAL MEMBRANE STATE BY GLYCYRRHETIC ACID DERIVATIVES IN LIVER PATHOLOGY IN In vivo EXPERIMENTS

Чулиев, Икром Неъматуллаевич, Асраров, Музаффар Исламович, Мейлиева, Озада Келдияровна

Қўқон ДПИ. Илмий хабарлар · 2026-yil

Annotatsiya

In the article, the effect of new synthetic derivatives of glycyrrhetic acid on the functional parameters of mitochondria, as well as the parameters of the CsA- sensitive pore of mitochondrial membranes, were studied. It is shown for the first time that derivatives of glycyrrhetic acid - 2-(N-cytisine)-ethyl-3-0-acetyl-18bH-glycyrrhetate, 2-(N- cytisine)-isopropyl-3-0-acetyl-18bH-glycyrrhetate and N-(2-pyridyl)-3-0-acetyl-11- ketoolean-12-en-30-amide inhibit the activity of the CsA-sensitive pore and have a protective effect on mitochondrial membranes.

Maqola ma’lumotlari
MualliflarЧулиев, Икром Неъматуллаевич, Асраров, Музаффар Исламович, Мейлиева, Озада Келдияровна
JurnalҚўқон ДПИ. Илмий хабарлар
Nashr sanasi2026-08-10
Jild8
Son07
Betlar553-565
TilIngliz
DOI10.70728/a.series.tab.v08.i07.074

Kalit so‘zlar

mitochondria, membrane permeability, CsA-sensitive pore, lipid peroxidation, oxidative phosphorylation, antioxidants, prooxidants, free radicals, apoptosis, necrosis, glycyrrhetic acid derivatives.

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