Pathophysiology of renal dysfunction in chronic obstructive lung disease: modern views

Sharipova N.S.

Ёш олимлар тиббиёт журнали · 2025-yil

Annotatsiya

Chronic obstructive pulmonary disease (COPD) is an irreversible chronic disease characterized by persistent and progressive narrowing of the airways, predominantly chronic bronchitis and pulmonary emphysema. Its development is caused by smoking (the main risk factor), air pollution, industrial dust, respiratory infections in childhood, and some genetic factors, in particular, α1-antitrypsin deficiency. Chronic inflammation in the small bronchi and alveoli, bronchial obstruction, destruction of alveolar structures, and gas exchange disorders play an important role in the pathogenesis of the disease. Chronic obstructive pulmonary disease (COPD) causes profound disorders not only of the respiratory system, but also of other vital organs, including the function of the kidneys. This article analyzes the main pathophysiological mechanisms of renal dysfunction developing against the background of COPD, including hypoxia, inflammatory mediators, neuroendocrine disorders, and hemodynamic disturbances. Decreased renal perfusion and activation of the renin-angiotensin-aldosterone system lead to structural changes in the renal tissue. Modern studies show that systemic inflammation and oxidative stress also play an important role in these processes. The article also provides a clinical assessment of the relationship between renal failure and COPD.

Maqola ma’lumotlari
MualliflarSharipova N.S.
JurnalЁш олимлар тиббиёт журнали
NashriyotТошкент тиббиёт академияси
ISSN2181-3485
Nashr sanasi2025-12-13
Son16
Betlar248-251
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

Chronic obstructive pulmonary disease, renal dysfunction, pathophysiology, hypoxia, inflammation, RAAS, oxidative stress, nephroprotection, systemic inflammation, comorbidity.

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APASharipova N.S. (2025). PATHOPHYSIOLOGY OF RENAL DYSFUNCTION IN CHRONIC OBSTRUCTIVE LUNG DISEASE: MODERN VIEWS. Ёш олимлар тиббиёт журнали, (16), 248-251. https://journals.tnmu.uz/index.php/yotj/article/view/3127
GOST (OAK)Sharipova N.S. PATHOPHYSIOLOGY OF RENAL DYSFUNCTION IN CHRONIC OBSTRUCTIVE LUNG DISEASE: MODERN VIEWS // Ёш олимлар тиббиёт журнали. – 2025. – № 16. – P. 248-251.
MLASharipova N.S. “PATHOPHYSIOLOGY OF RENAL DYSFUNCTION IN CHRONIC OBSTRUCTIVE LUNG DISEASE: MODERN VIEWS.” Ёш олимлар тиббиёт журнали, (16), 248-251, 2025. https://journals.tnmu.uz/index.php/yotj/article/view/3127
ChicagoSharipova N.S. “PATHOPHYSIOLOGY OF RENAL DYSFUNCTION IN CHRONIC OBSTRUCTIVE LUNG DISEASE: MODERN VIEWS.” Ёш олимлар тиббиёт журнали, (16), 248-251 (2025). https://journals.tnmu.uz/index.php/yotj/article/view/3127
HarvardSharipova N.S (2025) ‘PATHOPHYSIOLOGY OF RENAL DYSFUNCTION IN CHRONIC OBSTRUCTIVE LUNG DISEASE: MODERN VIEWS’, Ёш олимлар тиббиёт журнали, (16), 248-251. https://journals.tnmu.uz/index.php/yotj/article/view/3127
BibTeX
@article{sharipovans2025,
  title = {PATHOPHYSIOLOGY OF RENAL DYSFUNCTION IN CHRONIC OBSTRUCTIVE LUNG DISEASE: MODERN VIEWS},
  author = {Sharipova N.S.},
  journal = {Ёш олимлар тиббиёт журнали},
  year = {2025},
  number = {16},
  pages = {248-251},
  url = {https://journals.tnmu.uz/index.php/yotj/article/view/3127}
}

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