Synthesis and properties of azomethine derivatives of 2-AMINO-4,6- dihydroxypyrimidine (a comprehensive review)

Gulmira, Zayniddinovna Azimova, Zafar qizi Akbarkhanova, Zukhra

Қўқон ДПИ. Илмий хабарлар · 2026-yil

Annotatsiya

2-Amino-4,6-dihydroxypyrimidine (CAS 56-09-7) represents an indispensable heterocyclic building block widely exploited in organic synthesis, agrochemicals and pharmaceutical design. Although the baseline molecule features modest direct biological efficacy due to its highly stable, neutral tautomeric states, its unique spatial arrangement of three strong electron-donating groups unlocks exceptional reactivity. This review systematically maps the core chemical and physical properties of the molecule, addresses its dynamic keto-enol (lactam- lactim) structural isomerism, classifies its nucleophilic and electrophilic reaction centers and details the vast spectrum of biological activities—including antiviral, anticancer, anti- inflammatory and antimicrobial profiles – unlocked upon derivative functionalization.

Maqola ma’lumotlari
MualliflarGulmira, Zayniddinovna Azimova, Zafar qizi Akbarkhanova, Zukhra
JurnalҚўқон ДПИ. Илмий хабарлар
NashriyotҚўқон давлат педагогика институти
ISSN3030-3958
Nashr sanasi2026-09-05
Jild8
Son6
Betlar354-365
TilIngliz
DOI10.70728/a.series.tab.v08.i06.050
Indeksga qo‘shilgan2026-09-06

DOI: 10.70728/a.series.tab.v08.i06.050 · Maqolaning asl sahifasi

Kalit so‘zlar

Pyrimidine intermediate, tautomerism, electrophilic substitution, privileged scaffold.

Iqtibos keltirish

APAGulmira, Zayniddinovna Azimova, & Zafar qizi Akbarkhanova, Zukhra (2026). SYNTHESIS AND PROPERTIES OF AZOMETHINE DERIVATIVES OF 2-AMINO-4,6- DIHYDROXYPYRIMIDINE (A COMPREHENSIVE REVIEW). Қўқон ДПИ. Илмий хабарлар, 8(6), 354-365. https://doi.org/10.70728/a.series.tab.v08.i06.050
GOST (OAK)Gulmira, Zayniddinovna Azimova, Zafar qizi Akbarkhanova, Zukhra SYNTHESIS AND PROPERTIES OF AZOMETHINE DERIVATIVES OF 2-AMINO-4,6- DIHYDROXYPYRIMIDINE (A COMPREHENSIVE REVIEW) // Қўқон ДПИ. Илмий хабарлар. – 2026. – T. 8, № 6. – P. 354-365. – DOI: 10.70728/a.series.tab.v08.i06.050.
MLAGulmira, Zayniddinovna Azimova, and Zafar qizi Akbarkhanova, Zukhra. “SYNTHESIS AND PROPERTIES OF AZOMETHINE DERIVATIVES OF 2-AMINO-4,6- DIHYDROXYPYRIMIDINE (A COMPREHENSIVE REVIEW).” Қўқон ДПИ. Илмий хабарлар, 8(6), 354-365, 2026. https://doi.org/10.70728/a.series.tab.v08.i06.050
ChicagoGulmira, Zayniddinovna Azimova, and Zafar qizi Akbarkhanova, Zukhra. “SYNTHESIS AND PROPERTIES OF AZOMETHINE DERIVATIVES OF 2-AMINO-4,6- DIHYDROXYPYRIMIDINE (A COMPREHENSIVE REVIEW).” Қўқон ДПИ. Илмий хабарлар, 8(6), 354-365 (2026). https://doi.org/10.70728/a.series.tab.v08.i06.050
HarvardGulmira, Zayniddinovna Azimova, and Zafar qizi Akbarkhanova, Zukhra (2026) ‘SYNTHESIS AND PROPERTIES OF AZOMETHINE DERIVATIVES OF 2-AMINO-4,6- DIHYDROXYPYRIMIDINE (A COMPREHENSIVE REVIEW)’, Қўқон ДПИ. Илмий хабарлар, 8(6), 354-365. https://doi.org/10.70728/a.series.tab.v08.i06.050
BibTeX
@article{gulmirazayniddinovnaazimova2026,
  title = {SYNTHESIS AND PROPERTIES OF AZOMETHINE DERIVATIVES OF 2-AMINO-4,6- DIHYDROXYPYRIMIDINE (A COMPREHENSIVE REVIEW)},
  author = {Gulmira, Zayniddinovna Azimova and Zafar qizi Akbarkhanova, Zukhra},
  journal = {Қўқон ДПИ. Илмий хабарлар},
  year = {2026},
  volume = {8},
  number = {6},
  pages = {354-365},
  doi = {10.70728/a.series.tab.v08.i06.050},
  url = {https://doi.org/10.70728/a.series.tab.v08.i06.050}
}

Boshqa maqola uchun iqtibos tayyorlash

Қўқон ДПИ. Илмий хабарлар jurnalidan boshqa maqolalar

Қўқон ДПИ. Илмий хабарлар — barcha maqolalar · 2026-yil arxivi