Sensitivity, specificity, and prognostic efficacy indicators of the examined polymorphisms in the patients with necrotic process of maxillofacial region for risk-increasing alleles

Boymuradov Sh.A., Kurbanov Y.Kh., Narmurotov B.K., Djurayev J.A.

Гуманитар ва табиий фанлар журнали · 2026-yil

Annotatsiya

Genetic polymorphisms, particularly single nucleotide polymorphisms (SNPs), play an important role in determining individual susceptibility to disease, clinical progression, and treatment outcomes. This review summarizes current evidence on the sensitivity, specificity, and prognostic efficacy of examined polymorphisms in patient groups carrying risk-increasing alleles. The literature indicates that while many polymorphisms show statistically significant associations with disease risk and prognosis, their individual diagnostic performance is often limited due to modest effect sizes and population heterogeneity. Variations in genetic background, environmental factors, and study design further influence the predictive value of specific alleles. Recent approaches focusing on the combined analysis of multiple polymorphisms, including polygenic risk scores, demonstrate improved sensitivity and specificity compared with single-marker analyses. Integration of genetic data with clinical and demographic variables appears essential for enhancing prognostic accuracy. Overall, the findings highlight both the potential and the limitations of genetic polymorphisms as prognostic biomarkers and underscore the need for large, population-specific studies to support their application in personalized medicine.

Maqola ma’lumotlari
MualliflarBoymuradov Sh.A., Kurbanov Y.Kh., Narmurotov B.K., Djurayev J.A.
JurnalГуманитар ва табиий фанлар журнали
NashriyotEMU University
ISSN2026-2027, 2181-4007
Nashr sanasi2026-03-14
Son31
Betlar61-64
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

genetic polymorphisms; sensitivity and specificity; prognostic efficacy; risk-increasing alleles; polygenic risk assessment.

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APABoymuradov Sh.A., Kurbanov Y.Kh., Narmurotov B.K., Djurayev J.A. (2026). SENSITIVITY, SPECIFICITY, AND PROGNOSTIC EFFICACY INDICATORS OF THE EXAMINED POLYMORPHISMS IN THE PATIENTS WITH NECROTIC PROCESS OF MAXILLOFACIAL REGION FOR RISK-INCREASING ALLELES. Гуманитар ва табиий фанлар журнали, (31), 61-64. https://journals.tnmu.uz/index.php/gtfj/article/view/4185
GOST (OAK)Boymuradov Sh.A., Kurbanov Y.Kh., Narmurotov B.K., Djurayev J.A. SENSITIVITY, SPECIFICITY, AND PROGNOSTIC EFFICACY INDICATORS OF THE EXAMINED POLYMORPHISMS IN THE PATIENTS WITH NECROTIC PROCESS OF MAXILLOFACIAL REGION FOR RISK-INCREASING ALLELES // Гуманитар ва табиий фанлар журнали. – 2026. – № 31. – P. 61-64.
MLABoymuradov Sh.A., Kurbanov Y.Kh., Narmurotov B.K., Djurayev J.A. “SENSITIVITY, SPECIFICITY, AND PROGNOSTIC EFFICACY INDICATORS OF THE EXAMINED POLYMORPHISMS IN THE PATIENTS WITH NECROTIC PROCESS OF MAXILLOFACIAL REGION FOR RISK-INCREASING ALLELES.” Гуманитар ва табиий фанлар журнали, (31), 61-64, 2026. https://journals.tnmu.uz/index.php/gtfj/article/view/4185
ChicagoBoymuradov Sh.A., Kurbanov Y.Kh., Narmurotov B.K., Djurayev J.A. “SENSITIVITY, SPECIFICITY, AND PROGNOSTIC EFFICACY INDICATORS OF THE EXAMINED POLYMORPHISMS IN THE PATIENTS WITH NECROTIC PROCESS OF MAXILLOFACIAL REGION FOR RISK-INCREASING ALLELES.” Гуманитар ва табиий фанлар журнали, (31), 61-64 (2026). https://journals.tnmu.uz/index.php/gtfj/article/view/4185
HarvardBoymuradov Sh.A., Kurbanov Y.Kh., Narmurotov B.K., Djurayev J.A (2026) ‘SENSITIVITY, SPECIFICITY, AND PROGNOSTIC EFFICACY INDICATORS OF THE EXAMINED POLYMORPHISMS IN THE PATIENTS WITH NECROTIC PROCESS OF MAXILLOFACIAL REGION FOR RISK-INCREASING ALLELES’, Гуманитар ва табиий фанлар журнали, (31), 61-64. https://journals.tnmu.uz/index.php/gtfj/article/view/4185
BibTeX
@article{boymuradovshakurbanovykhnarmurotovbkdjurayevja2026,
  title = {SENSITIVITY, SPECIFICITY, AND PROGNOSTIC EFFICACY INDICATORS OF THE EXAMINED POLYMORPHISMS IN THE PATIENTS WITH NECROTIC PROCESS OF MAXILLOFACIAL REGION FOR RISK-INCREASING ALLELES},
  author = {Boymuradov Sh.A., Kurbanov Y.Kh., Narmurotov B.K., Djurayev J.A.},
  journal = {Гуманитар ва табиий фанлар журнали},
  year = {2026},
  number = {31},
  pages = {61-64},
  url = {https://journals.tnmu.uz/index.php/gtfj/article/view/4185}
}

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