Study of morphometric changes in liver parenchyma in anti-inflammatory drug polypragmasia

Usanov , Sanjar, Abduraimov , Zafarjon, Усанов , Санжар, Абдураимов , Зафаржон, Usanov , Sanjar, Abduraimov , Zafarjon

Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi · 2024-yil

Annotatsiya

Objective: To study morphometric changes in the structure of the liver of white rats with polypharmacy with anti-inflammatory drugs. Methods: The study was carried out on 50 male white rats, weighing from 210 to 320 g, kept in a vivarium with a standard diet, free access to water, and a normal lighting regime. The animals were divided into 3 groups. Results: When comparing the morphometric parameters of the rats of the 3rd group with those of the 2nd group, a significant decrease was found. The area of the hepatic cell decreased 5.14%, 5.05%, 3.19% and 3.02%, the outer diameter of the central vena decreased 8.13%, 6.11%, 4.08% and 3.42%, the diameter of the biliary duct decreased by 6.33%, 5.09%, 3.12% and 3.08%, the outer diameter of the arterial decreased by 7.12%, 5.07%, 5.03% and 4.48%, the diameter of the hepatic biliary duct decreased by 4.47%, 4.04%, 3.07% and 2.31%. Conclusions. The presence of the effect of polypharmacy by anti-inflammatory drugs on the liver indicates that polypharmacy has a detrimental effect on urinary excretion, reduces biliary excretion and has a sufficient level of risk for the body.

Maqola ma’lumotlari
MualliflarUsanov , Sanjar, Abduraimov , Zafarjon, Усанов , Санжар, Абдураимов , Зафаржон, Usanov , Sanjar, Abduraimov , Zafarjon
JurnalMedical science of Uzbekistan / O'zbekiston tibbiyot ilmi
NashriyotАндижон давлат тиббиёт институти
ISSN2181-3612
Nashr sanasi2024-02-26
Jild3
Son1
Betlar13-17
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/2181-3612-2024-1-13-17
Indeksga qo‘shilgan2026-08-26

DOI: 10.56121/2181-3612-2024-1-13-17 · Maqolaning asl sahifasi

Kalit so‘zlar

liver, parenchimy, central vena, biliary duct, polypharmacy, печень, паренхима, центральная Вена, желчные протоки, полипрагмазия, jigar, parenxima, markaziy vena, o‘t yo‘llari, polipragmaziya

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAUsanov , Sanjar, Abduraimov , Zafarjon, Усанов , Санжар, Абдураимов , Зафаржон, Usanov , Sanjar, & Abduraimov , Zafarjon (2024). STUDY OF MORPHOMETRIC CHANGES IN LIVER PARENCHYMA IN ANTI-INFLAMMATORY DRUG POLYPRAGMASIA. Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 3(1), 13-17. https://doi.org/10.56121/2181-3612-2024-1-13-17
GOST (OAK)Usanov , Sanjar va b. STUDY OF MORPHOMETRIC CHANGES IN LIVER PARENCHYMA IN ANTI-INFLAMMATORY DRUG POLYPRAGMASIA // Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi. – 2024. – T. 3, № 1. – P. 13-17. – DOI: 10.56121/2181-3612-2024-1-13-17.
MLAUsanov , Sanjar, Abduraimov , Zafarjon, Усанов , Санжар, Абдураимов , Зафаржон, Usanov , Sanjar, and Abduraimov , Zafarjon. “STUDY OF MORPHOMETRIC CHANGES IN LIVER PARENCHYMA IN ANTI-INFLAMMATORY DRUG POLYPRAGMASIA.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 3(1), 13-17, 2024. https://doi.org/10.56121/2181-3612-2024-1-13-17
ChicagoUsanov , Sanjar, Abduraimov , Zafarjon, Усанов , Санжар, Абдураимов , Зафаржон, Usanov , Sanjar, and Abduraimov , Zafarjon. “STUDY OF MORPHOMETRIC CHANGES IN LIVER PARENCHYMA IN ANTI-INFLAMMATORY DRUG POLYPRAGMASIA.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 3(1), 13-17 (2024). https://doi.org/10.56121/2181-3612-2024-1-13-17
HarvardUsanov , Sanjar, Abduraimov , Zafarjon, Усанов , Санжар, Абдураимов , Зафаржон, Usanov , Sanjar, and Abduraimov , Zafarjon (2024) ‘STUDY OF MORPHOMETRIC CHANGES IN LIVER PARENCHYMA IN ANTI-INFLAMMATORY DRUG POLYPRAGMASIA’, Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 3(1), 13-17. https://doi.org/10.56121/2181-3612-2024-1-13-17
BibTeX
@article{usanovsanjar2024,
  title = {STUDY OF MORPHOMETRIC CHANGES IN LIVER PARENCHYMA IN ANTI-INFLAMMATORY DRUG POLYPRAGMASIA},
  author = {Usanov , Sanjar and Abduraimov , Zafarjon and Усанов , Санжар and Абдураимов , Зафаржон and Usanov , Sanjar and Abduraimov , Zafarjon},
  journal = {Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi},
  year = {2024},
  volume = {3},
  number = {1},
  pages = {13-17},
  doi = {10.56121/2181-3612-2024-1-13-17},
  url = {https://doi.org/10.56121/2181-3612-2024-1-13-17}
}

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