Objective: To study morphometric changes in the structure of the liver of white rats with polypharmacy with anti-inflammatory drugs. Methods: The study was carried out on 50 male white rats, weighing from 210 to 320 g, kept in a vivarium with a standard diet, free access to water, and a normal lighting regime. The animals were divided into 3 groups. Results: When comparing the morphometric parameters of the rats of the 3rd group with those of the 2nd group, a significant decrease was found. The area of the hepatic cell decreased 5.14%, 5.05%, 3.19% and 3.02%, the outer diameter of the central vena decreased 8.13%, 6.11%, 4.08% and 3.42%, the diameter of the biliary duct decreased by 6.33%, 5.09%, 3.12% and 3.08%, the outer diameter of the arterial decreased by 7.12%, 5.07%, 5.03% and 4.48%, the diameter of the hepatic biliary duct decreased by 4.47%, 4.04%, 3.07% and 2.31%. Conclusions. The presence of the effect of polypharmacy by anti-inflammatory drugs on the liver indicates that polypharmacy has a detrimental effect on urinary excretion, reduces biliary excretion and has a sufficient level of risk for the body.
| Mualliflar | Usanov , Sanjar, Abduraimov , Zafarjon, Усанов , Санжар, Абдураимов , Зафаржон, Usanov , Sanjar, Abduraimov , Zafarjon |
|---|---|
| Jurnal | Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi |
| Nashr sanasi | 2024-02-26 |
| Jild | 3 |
| Son | 1 |
| Betlar | 13-17 |
| Til | uz_Latn |
| DOI | 10.56121/2181-3612-2024-1-13-17 |
DOI: 10.56121/2181-3612-2024-1-13-17 · Maqolaning asl sahifasi
liver, parenchimy, central vena, biliary duct, polypharmacy, печень, паренхима, центральная Вена, желчные протоки, полипрагмазия, jigar, parenxima, markaziy vena, o‘t yo‘llari, polipragmaziya
This review article is aimed at studying the effectiveness of preserving the alveolar process during tooth extraction. Based on the literature, all methods for preserving alveolar bone volume have been studied. Based on…
Tear separation is a fairly significant group among all eye diseases and is distinguished by the fact that it occupies a high place in the structure of diseases. According to a number of authors, 8-25.6% of outpatients…
Until now, more than 40% of beds in dental hospitals are occupied by patients with inflammatory processes in the maxillofacial region. The increase in the number of slowly acting hyporeactive forms of inflammation in…
Atrophic rhinitis is a chronic inflammatory process of the nasal cavity, characterized by atrophy of the nasal mucosa, and the inflammatory process also affects the glands and nasal concha. In this article, the authors…
Currently, juvenile idiopathic arthritis (JIA) has become a medical and social problem. This is fundamentally associated with a significant increase in the number of diseases among children, often with severe…
The analysis of the effectiveness of ozone therapy with intravenous drug Cavintonum the treatment of sensory-neural hypoacusis of vascular origin due to chronic insufficiency of cerebral circulation in vertebrobasilar…
In order to classify patients with ear malformations and treat them effectively, accurate knowledge and a uniform description of defects are necessary. A complete study. Clinical and audiometric research methods can be…
The health status of children worsens over the years of schooling; the creation of health and rehabilitation programs for students remains especially relevant. This review article is devoted to one of the pressing…
Depression is one of the most prevalent mental disorders, characterized by sad mood, loss of interest in life, and diminished pleasure in usual activities. This review article examines an integrative approach to…
The purpose of our work was to study the characteristics of psycho-emotional reactions in schoolchildren with maladaptive disorders. The material and method for the study were schoolchildren with maladaptive disorders…
Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi — barcha maqolalar