The relationship between vitamin d levels and anxiety-depressive disorders and the severity of chronic obstructive pulmonary disease

Fattakhova Yulia Edgarovna

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2026-yil

Annotatsiya

Objective: to study the relationship between serum vitamin D levels, the presence of anxiety and depressive disorders, and the severity of the clinical course of chronic obstructive pulmonary disease.Materials and methods. The study included 100 patients with COPD aged 38-82 years who underwent examination and treatment at the Republican Specialized Scientific and Practical Medical Center of Phthisiology and Pulmonology named after Academician Sh.A. Alimov. Psychoemotional status was assessed using the HADS and CES-D scales, dyspnea severity using the mMRC scale, symptom burden using the CAT questionnaire, and pulmonary function by forced spirometry with determination of FEV1. Serum 25(OH)D concentration was measured.Results. Anxiety and depressive disorders (HADS >=11 and/or CES-D >=17) were identified in 78.0% of patients. Severe COPD was more common in patients with anxiety and depressive disorders: the proportion of GOLD III-IV was 91.0% versus 45.5% in the group without these disorders. Patients with anxiety and depressive disorders had lower FEV1 values (35.1+-1.5% vs 55.9+-5.6% of predicted; p<0.001), higher CAT scores (25.9+-0.6 vs 15.1+-1.6 points; p<0.001), and more pronounced dyspnea according to mMRC (3.3+-0.08 vs 1.73+-0.26 points; p<0.001). The serum 25(OH)D concentration in the COPD+anxiety/depression group was significantly lower than in patients without anxiety and depressive disorders (30.58+-1.9 vs 46.9+-2.8 ng/mL; p<0.001), and logistic regression analysis showed that 25(OH)D levels <30 ng/mL were associated with an increased risk of a more severe clinical course (OR=3.8).Conclusion. The obtained data confirm the relationship between anxiety and depressive disorders, more severe COPD, reduced FEV1, and low vitamin D levels. Assessment of serum 25(OH)D and psychoemotional status may be considered an important component of the comprehensive evaluation of patients with COPD.

Maqola ma’lumotlari
MualliflarFattakhova Yulia Edgarovna
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2026-05-20
Jild11
Son2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

. Хроническая венозная недостаточность, хирургическое лечение, chronic obstructive pulmonary disease; COPD; anxiety and depressive disorders; depression; vitamin D; FEV1; CAT; mMRC, surunkali obstruktiv o'pka kasalligi; SO'OK; tashvishli-depressiv buzilishlar; depressiya; vitamin D; OFV1; CAT; mMRC

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAFattakhova Yulia Edgarovna (2026). THE RELATIONSHIP BETWEEN VITAMIN D LEVELS AND ANXIETY-DEPRESSIVE DISORDERS AND THE SEVERITY OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(2). https://tadqiqot.uz/index.php/biomedicine/article/view/13883
GOST (OAK)Fattakhova Yulia Edgarovna THE RELATIONSHIP BETWEEN VITAMIN D LEVELS AND ANXIETY-DEPRESSIVE DISORDERS AND THE SEVERITY OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 11, № 2.
MLAFattakhova Yulia Edgarovna. “THE RELATIONSHIP BETWEEN VITAMIN D LEVELS AND ANXIETY-DEPRESSIVE DISORDERS AND THE SEVERITY OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(2), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/13883
ChicagoFattakhova Yulia Edgarovna. “THE RELATIONSHIP BETWEEN VITAMIN D LEVELS AND ANXIETY-DEPRESSIVE DISORDERS AND THE SEVERITY OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(2) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/13883
HarvardFattakhova Yulia Edgarovna (2026) ‘THE RELATIONSHIP BETWEEN VITAMIN D LEVELS AND ANXIETY-DEPRESSIVE DISORDERS AND THE SEVERITY OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(2). https://tadqiqot.uz/index.php/biomedicine/article/view/13883
BibTeX
@article{fattakhovayuliaedgarovna2026,
  title = {THE RELATIONSHIP BETWEEN VITAMIN D LEVELS AND ANXIETY-DEPRESSIVE DISORDERS AND THE SEVERITY OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE},
  author = {Fattakhova Yulia Edgarovna},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2026},
  volume = {11},
  number = {2},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/13883}
}

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