Association of Endothelin-1 gene LYS198ASР polymorphisms with chronical obstructive pulmonary disease in Uzbek population patients

Abduganieva, E.A., Liverko, I.V., Boboev, A.T., Абдуганиева, Э.А., Ливерко, И.В., Бобоев, А.Т., Абдуганиева, Э.А., Ливерко, И.В., Бобоев, А.Т.

Жамият ва инновациялар / Общество и инновации / Society and innovations · 2020-yil

Annotatsiya

In the article, in order to identify the role of mutations and polymorphisms of the endothelin-1 gene Lys198Asn in the development of COPD, the authors studied 49 patients with an established diagnosis of COPD. The control group consisted of 46 apparently healthy patients, comparable with the main group in terms of age and sex. The study of mutations and polymorphism of the endothelin-1 gene Lys198Asn was carried out by PCR, statistical analysis was carried out using the statistical software "OpenEpi, Version 2.9". As a result, it was found that the heterozygous Lys / Asp genotype of the endothelin-1 gene Lys198Asn was found in the COPD group 1.25 times more often than in the control group. It was found that the mutational genotype Asp / Asp - was found in the COPD group 1.9 times more often than in the control group (RR 1.9, OR - 2.3; χ2 = 0.4), which indirectly shows the significance of changes in this gene in the development of COPD, and its course. The influence of the presence of a genotypic predisposition to endothelial dysfunction with its phenotypic manifestations was evaluated.

Maqola ma’lumotlari
MualliflarAbduganieva, E.A., Liverko, I.V., Boboev, A.T., Абдуганиева, Э.А., Ливерко, И.В., Бобоев, А.Т., Абдуганиева, Э.А., Ливерко, И.В., Бобоев, А.Т.
JurnalЖамият ва инновациялар / Общество и инновации / Society and innovations
NashriyotIn Science МЧЖ
ISSN2181-1415
Nashr sanasi2020-12-15
Jild1
Son2/S
Betlar407-413
TilIngliz
Ilmiy sohaTibbiyot
DOI10.47689/2181-1415-vol1-iss2/s-pp407-413
Indeksga qo‘shilgan2026-08-26

DOI: 10.47689/2181-1415-vol1-iss2/s-pp407-413 · Maqolaning asl sahifasi

Kalit so‘zlar

Хроническая обструктивная болезнь легких, эндотелин -1, дисфункция эндотелия, предиктор, Chronic obstructive pulmonary disease, endothelin-1, endothelium dysfunction, predictor

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAAbduganieva, E.A., Liverko, I.V., Boboev, A.T., Абдуганиева, Э.А., Ливерко, И.В., Бобоев, А.Т., Абдуганиева, Э.А., Ливерко, И.В., & Бобоев, А.Т. (2020). Association of Endothelin-1 gene LYS198ASР polymorphisms with chronical obstructive pulmonary disease in Uzbek population patients. Жамият ва инновациялар / Общество и инновации / Society and innovations, 1(2/S), 407-413. https://doi.org/10.47689/2181-1415-vol1-iss2/s-pp407-413
GOST (OAK)Abduganieva, E.A. va b. Association of Endothelin-1 gene LYS198ASР polymorphisms with chronical obstructive pulmonary disease in Uzbek population patients // Жамият ва инновациялар / Общество и инновации / Society and innovations. – 2020. – T. 1, № 2/S. – P. 407-413. – DOI: 10.47689/2181-1415-vol1-iss2/s-pp407-413.
MLAAbduganieva, E.A., Liverko, I.V., Boboev, A.T., Абдуганиева, Э.А., Ливерко, И.В., Бобоев, А.Т., Абдуганиева, Э.А., Ливерко, И.В., and Бобоев, А.Т. “Association of Endothelin-1 gene LYS198ASР polymorphisms with chronical obstructive pulmonary disease in Uzbek population patients.” Жамият ва инновациялар / Общество и инновации / Society and innovations, 1(2/S), 407-413, 2020. https://doi.org/10.47689/2181-1415-vol1-iss2/s-pp407-413
ChicagoAbduganieva, E.A., Liverko, I.V., Boboev, A.T., Абдуганиева, Э.А., Ливерко, И.В., Бобоев, А.Т., Абдуганиева, Э.А., Ливерко, И.В., and Бобоев, А.Т. “Association of Endothelin-1 gene LYS198ASР polymorphisms with chronical obstructive pulmonary disease in Uzbek population patients.” Жамият ва инновациялар / Общество и инновации / Society and innovations, 1(2/S), 407-413 (2020). https://doi.org/10.47689/2181-1415-vol1-iss2/s-pp407-413
HarvardAbduganieva, E.A., Liverko, I.V., Boboev, A.T., Абдуганиева, Э.А., Ливерко, И.В., Бобоев, А.Т., Абдуганиева, Э.А., Ливерко, И.В., and Бобоев, А.Т (2020) ‘Association of Endothelin-1 gene LYS198ASР polymorphisms with chronical obstructive pulmonary disease in Uzbek population patients’, Жамият ва инновациялар / Общество и инновации / Society and innovations, 1(2/S), 407-413. https://doi.org/10.47689/2181-1415-vol1-iss2/s-pp407-413
BibTeX
@article{abduganievaea2020,
  title = {Association of Endothelin-1 gene LYS198ASР polymorphisms with chronical obstructive pulmonary disease in Uzbek population patients},
  author = {Abduganieva, E.A. and Liverko, I.V. and Boboev, A.T. and Абдуганиева, Э.А. and Ливерко, И.В. and Бобоев, А.Т. and Абдуганиева, Э.А. and Ливерко, И.В. and Бобоев, А.Т.},
  journal = {Жамият ва инновациялар / Общество и инновации / Society and innovations},
  year = {2020},
  volume = {1},
  number = {2/S},
  pages = {407-413},
  doi = {10.47689/2181-1415-vol1-iss2/s-pp407-413},
  url = {https://doi.org/10.47689/2181-1415-vol1-iss2/s-pp407-413}
}

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