In the article, in order to identify the role of mutations and polymorphisms of the endothelin-1 gene Lys198Asn in the development of COPD, the authors studied 49 patients with an established diagnosis of COPD. The control group consisted of 46 apparently healthy patients, comparable with the main group in terms of age and sex. The study of mutations and polymorphism of the endothelin-1 gene Lys198Asn was carried out by PCR, statistical analysis was carried out using the statistical software "OpenEpi, Version 2.9". As a result, it was found that the heterozygous Lys / Asp genotype of the endothelin-1 gene Lys198Asn was found in the COPD group 1.25 times more often than in the control group. It was found that the mutational genotype Asp / Asp - was found in the COPD group 1.9 times more often than in the control group (RR 1.9, OR - 2.3; χ2 = 0.4), which indirectly shows the significance of changes in this gene in the development of COPD, and its course. The influence of the presence of a genotypic predisposition to endothelial dysfunction with its phenotypic manifestations was evaluated.
| Mualliflar | Abduganieva, E.A., Liverko, I.V., Boboev, A.T., Абдуганиева, Э.А., Ливерко, И.В., Бобоев, А.Т., Абдуганиева, Э.А., Ливерко, И.В., Бобоев, А.Т. |
|---|---|
| Jurnal | Жамият ва инновациялар / Общество и инновации / Society and innovations |
| Nashr sanasi | 2020-12-15 |
| Jild | 1 |
| Son | 2/S |
| Betlar | 407-413 |
| Til | Rus |
| DOI | 10.47689/2181-1415-vol1-iss2/s-pp407-413 |
DOI: 10.47689/2181-1415-vol1-iss2/s-pp407-413 · Maqolaning asl sahifasi
Хроническая обструктивная болезнь легких, эндотелин -1, дисфункция эндотелия, предиктор, Chronic obstructive pulmonary disease, endothelin-1, endothelium dysfunction, predictor
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Жамият ва инновациялар / Общество и инновации / Society and innovations — barcha maqolalar