Metabolic nature of obesity and prediabetes in the context of peripheral neuropathy

Kodirova Nargizakhon Umarovna, Djuraeva Aziza Shakhzadeevna

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2025-yil

Annotatsiya

The article examines the metabolic nature of peripheral neuropathy developing in the context of obesity and prediabetes, irrespective of the manifestation of diabetes mellitus. The aim of the study is to present a systematic review of the pathogenetic mechanisms, clinical features, and modern diagnostic strategies based on evidence. Special attention is given to the role of insulin resistance, chronic low-grade inflammation, adipokine imbalance, and oxidative stress as key links in neurodegeneration. Distinctive characteristics of prediabetic and metabolic neuropathy are discussed, including isolated involvement of small sensory fibers and the challenges of early detection. Comparative analysis of current diagnostic scales and methods (NSS, NDS, QST, EMG) is provided, as well as substantiated approaches to prevention involving lifestyle modification, nutritional support, and pharmacological intervention. The potential reversibility of early neurophysiological impairments through comprehensive intervention is emphasized. The conclusion stresses the need for an interdisciplinary approach and recognition of metabolic neuropathy as an independent nosological entity.

Maqola ma’lumotlari
MualliflarKodirova Nargizakhon Umarovna, Djuraeva Aziza Shakhzadeevna
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2025-11-03
Jild10
Son4
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

инсулинорезистентность, метаболическая нейропатия, ожирение, периферическая полинейропатия, предиабет., insulin resistance, metabolic neuropathy, obesity, peripheral polyneuropathy, prediabetes., : insulin qarshiligi, metabolik neyropatiya, semirish, periferik polinevopatiya, prediabet.

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAKodirova Nargizakhon Umarovna, & Djuraeva Aziza Shakhzadeevna (2025). METABOLIC NATURE OF OBESITY AND PREDIABETES IN THE CONTEXT OF PERIPHERAL NEUROPATHY. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(4). https://tadqiqot.uz/index.php/biomedicine/article/view/12783
GOST (OAK)Kodirova Nargizakhon Umarovna, Djuraeva Aziza Shakhzadeevna METABOLIC NATURE OF OBESITY AND PREDIABETES IN THE CONTEXT OF PERIPHERAL NEUROPATHY // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2025. – T. 10, № 4.
MLAKodirova Nargizakhon Umarovna, and Djuraeva Aziza Shakhzadeevna. “METABOLIC NATURE OF OBESITY AND PREDIABETES IN THE CONTEXT OF PERIPHERAL NEUROPATHY.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(4), 2025. https://tadqiqot.uz/index.php/biomedicine/article/view/12783
ChicagoKodirova Nargizakhon Umarovna, and Djuraeva Aziza Shakhzadeevna. “METABOLIC NATURE OF OBESITY AND PREDIABETES IN THE CONTEXT OF PERIPHERAL NEUROPATHY.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(4) (2025). https://tadqiqot.uz/index.php/biomedicine/article/view/12783
HarvardKodirova Nargizakhon Umarovna, and Djuraeva Aziza Shakhzadeevna (2025) ‘METABOLIC NATURE OF OBESITY AND PREDIABETES IN THE CONTEXT OF PERIPHERAL NEUROPATHY’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(4). https://tadqiqot.uz/index.php/biomedicine/article/view/12783
BibTeX
@article{kodirovanargizakhonumarovna2025,
  title = {METABOLIC NATURE OF OBESITY AND PREDIABETES IN THE CONTEXT OF PERIPHERAL NEUROPATHY},
  author = {Kodirova Nargizakhon Umarovna and Djuraeva Aziza Shakhzadeevna},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2025},
  volume = {10},
  number = {4},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/12783}
}

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