Molecular mechanisms of immunological activation in HIV infection

QODIROV Jonibek Fayzullayevich, RIZAEV Jasur Alimdjanovich, ZIYADULLAEV Shukhrat Khudayberdiyevich

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2025-yil

Annotatsiya

The role of the innate immune system, pattern recognition receptors, TLR, CLR and RLR, are known to be key in the response to HIV infection. Activation of the receptors leads to the production of type I interferons, which helps limit viral replication in the early stages of infection. However, chronic interaction of HIV with the immune system causes long-term activation of these pathways, which can lead to inflammation and disruption of immune homeostasis. An important aspect is the interferon-stimulated genes ISG, which play a key role in host defense, but HIV has evolved to suppress these mechanisms, which contributes to its long-term existence in the body. This article reviews various molecules and mechanisms of immune defense, including the role of interferons and their receptors, as well as APOBEC3G and ISG15 molecules, which are involved in antiviral activity and may be potential targets for therapeutic interventions.

Maqola ma’lumotlari
MualliflarQODIROV Jonibek Fayzullayevich, RIZAEV Jasur Alimdjanovich, ZIYADULLAEV Shukhrat Khudayberdiyevich
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2025-03-18
Jild10
Son1
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-09-13

Maqolaning asl sahifasi

Kalit so‘zlar

ВИЧ, СПИД, CD4+, репликация, интерфероны, TLR, CLR, RLR, интерферон-стимулированные гены ISG, HIV, AIDS, CD4+, replication, interferons, TLR, CLR, RLR, interferon-stimulated genes ISG, OIV, OITS, CD4+, replikatsiya, interferonlar, TLR, CLR, RLR, interferon bilan rag‘batlantirilgan genlar ISG

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAQODIROV Jonibek Fayzullayevich, RIZAEV Jasur Alimdjanovich, & ZIYADULLAEV Shukhrat Khudayberdiyevich (2025). MOLECULAR MECHANISMS OF IMMUNOLOGICAL ACTIVATION IN HIV INFECTION. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(1). https://tadqiqot.uz/index.php/biomedicine/article/view/11121
GOST (OAK)QODIROV Jonibek Fayzullayevich, RIZAEV Jasur Alimdjanovich, ZIYADULLAEV Shukhrat Khudayberdiyevich MOLECULAR MECHANISMS OF IMMUNOLOGICAL ACTIVATION IN HIV INFECTION // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2025. – T. 10, № 1.
MLAQODIROV Jonibek Fayzullayevich, RIZAEV Jasur Alimdjanovich, and ZIYADULLAEV Shukhrat Khudayberdiyevich. “MOLECULAR MECHANISMS OF IMMUNOLOGICAL ACTIVATION IN HIV INFECTION.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(1), 2025. https://tadqiqot.uz/index.php/biomedicine/article/view/11121
ChicagoQODIROV Jonibek Fayzullayevich, RIZAEV Jasur Alimdjanovich, and ZIYADULLAEV Shukhrat Khudayberdiyevich. “MOLECULAR MECHANISMS OF IMMUNOLOGICAL ACTIVATION IN HIV INFECTION.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(1) (2025). https://tadqiqot.uz/index.php/biomedicine/article/view/11121
HarvardQODIROV Jonibek Fayzullayevich, RIZAEV Jasur Alimdjanovich, and ZIYADULLAEV Shukhrat Khudayberdiyevich (2025) ‘MOLECULAR MECHANISMS OF IMMUNOLOGICAL ACTIVATION IN HIV INFECTION’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(1). https://tadqiqot.uz/index.php/biomedicine/article/view/11121
BibTeX
@article{qodirovjonibekfayzullayevich2025,
  title = {MOLECULAR MECHANISMS OF IMMUNOLOGICAL ACTIVATION IN HIV INFECTION},
  author = {QODIROV Jonibek Fayzullayevich and RIZAEV Jasur Alimdjanovich and ZIYADULLAEV Shukhrat Khudayberdiyevich},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2025},
  volume = {10},
  number = {1},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/11121}
}

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