While current treatments targeting vascular endothelial growth factor (VEGF) show effectiveness, there's still a call for more therapeutic options that can either enhance treatment outcomes or lessen the need for frequent injections and monitoring in diabetic macular edema (DME) patients. This study aims to assess the performance and safety of brolucizumab compared to aflibercept, administered every four weeks to individuals with DME. Conducted over 52 weeks and double-blinded, this phase 3 trial included adults new to treatment and those who had previously undergone anti-VEGF therapy, with data collection from September 2019 to March 2020 and analysis from April 2020 to February 2021. The intervention involved administering 6 mg of brolucizumab or 2 mg of aflibercept via intravitreal injection every four weeks. Participants were assigned in a 2:1 ratio to either treatment, focusing on primary outcomes like the change in best-corrected visual acuity by week 52, and secondary outcomes including improvements in the Diabetic Retinopathy Severity Scale score, absence of subretinal and intraretinal fluid, changes in central subfield thickness, and overall safety. The trial randomized 217 participants, with a majority being male and an average age of 60.7 years. Brolucizumab showed comparable efficacy to aflibercept regarding visual acuity improvement and demonstrated superiority in reducing subretinal and intraretinal fluid and central subfield thickness. The occurrence of intraocular inflammation, retinal vasculitis, and vascular occlusion was slightly higher in the brolucizumab group, with one case of retinal artery occlusion. Ultimately, the study found no significant difference in visual outcomes between the two treatments, though brolucizumab exhibited certain anatomical advantages without raising new safety issues.
| Mualliflar | XAMIDULLAYEV Firdavs Faridunovich, NORMATOVA Nargiza Mirshovkatovna, NEMATULLOEV Tukhtasin Komiljonovich |
|---|---|
| Jurnal | Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali |
| Nashr sanasi | 2024-06-15 |
| Jild | 9 |
| Son | 2 |
| Til | Ingliz |
Диабетический макулярный отек (DME), Сосудистый эндотелиальный фактор роста (VEGF), Бролуцизумаб, Афлиберцепт, Внутриглазные инъекции, Улучшение остроты зрения, Diabetic Macular Edema (DME), Vascular Endothelial Growth Factor (VEGF), Brolucizumab, Aflibercept, Intravitreal Injection, Visual Acuity Improvement, Diabetik makulyar shish (DME), Vaskulyar endotelial o'sish faktori (VEGF), Brolutsizumab, Aflibersept, Intravitreal in'ektsiya, Ko'rish aniqligini yaxshilash
Intraocular lenses (IOLs) are used in ophthalmology to restore vision after removal of the natural lens, for example, to patients with cataracts. In the case of vitreectomy, which is a surgical procedure to remove the…
The purpose of this study is to compare the nature of the clinical course of measles in children under one year of age who were breastfed with those who were bottle-fed. The clinical diagnosis of measles was established…
In our study the association of T-31C polymorphism in the IL1B gene and risk of atonic postpartum hemorrhage in women of Uzbek nationality were identified. 101 women with postpartum atonic bleeding were studied. An…
The purpose of investigation was to study cultural and proteolytic properties of Candida family yeast-like fungi. It is stated, that natural variability of C.albicans colonies morphology depends on storage period of…
The article presents data on the fact that nowadays there is an urgent need to develop the pathogenic direction of studying the influence of environmental factors in general and atmospheric air, in particular, on the…
In the study of patients with COVID-19, those with CVH (CCHF) had increased levels of proinflammatory cytokine/IL-6, medium molecular weight peptides, and C-reactive protein (CRP). These markers were found to be…
In the article, the main tasks for the transformation of the healthcare system according to the reforms of the administrative management implemented in the Republic of Uzbekistan are taken as a basis. In order to ensure…
In this study, we investigated the safety of highly active antiretroviral therapy in HIV-infected patients. It is shown that as a result of the ineffectiveness and / or as a result of side effects of this therapy in…
All 118 patients suffering from liver echinococcosis and its complications underwent comprehensive diagnostics. In each of the 118 cases, the presence of liver echinococcosis and its complications was confirmed using…
The widespread prevalence of rickettsioses in the republic determines the need to improve diagnostics using epidemiological, clinical and laboratory methods. The clinical and laboratory features of the course of…
Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali — barcha maqolalar