Purpose: to study the relationship between the level of brain-derived neurotrophic factor and the incidence of acute ischemic stroke in young people. Materials and methods: The study included 83 patients aged 22-44 years (main group) who had suffered acute ischemic stroke (males - 41 (49.4%), females 42 (50.6%); average age 38.71±6.5 years). The control group consisted of 54 practically healthy individuals, comparable in age and gender (males 31 (57,4%), females 23 (42,6%); average age 38,59±6,64 years. Quantitative determination of brain-derived neurotrophic factor (BDNF) was carried out using enzyme-linked immunosorbent assay. Results: A careful study of the data presented in the above table revealed an inverse correlation between the concentration of the biomarker and the severity of the disease and the severity of neurological symptoms. In patients with a mild degree of neurological impairment according to the NIHSS scale, we observed a high concentration of serum BDNF and, conversely, a decrease in its level was determined in patients with an extremely severe degree of neurological deficit (r=-0,137, p<0,05). When conducting an intragroup analysis of the quantitative determination of serum BDNF in patients, depending on the pathogenetic subtype of IS, a relationship was established between the level of neurotrophin and the severity of neurological disorders, while the lowest level of this biomarker was observed in patients with hemodynamic stroke. Conclusion: Patients with the lowest BDNF values have an increased risk of unfavorable outcome of ischemic stroke and a low level of rehabilitation potential, while increased levels of this marker in the brain contribute to the restoration of lost functions.
| Mualliflar | KIM Olga Anatolevna |
|---|---|
| Jurnal | Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali |
| Nashr sanasi | 2024-04-14 |
| Jild | 9 |
| Son | 1 |
| Til | Rus |
ишемический инсульт, молодой возраст, патогенетические подтипы, мозговой нейротрофический фактор, NIHSS, ischemic stroke, young age, pathogenetic subtypes, brain-derived neurotrophic factor, NIHSS., ishemik insult, yoshlar, patogenetik subtiplar, miya neyrotrofik omil, NIHSS
Aim: A comparative study of macro- and microstructural indicators of the brain of young patients with ischemic stroke due to alcohol dependence. Materials and methods. The study included 62 patients in the acute period…
Aim: identification of clinical manifestations of “text neck” syndrome in children playing chess. Materials and methods. Our study included 45 chess athletes aged 10-17 years (average age 14.6±0.89 years), of…
Vitamin D deficiency is usually caused by insufficient synthesis of the vitamin in the body due to insufficient sun exposure and/or a decrease in the synthetic properties of the skin with age. Persistent, severe vitamin…
This article examines the importance of the immune system and its impact on sports activity. The immune system is a complex of organs widely distributed in the body. The main components of the immune system interact…
The state of pathomorphological changes in the pathogenetic angiogenic factor of aseptic necrosis of the femoral head is described and discussed. Pathomorphological changes in the pathogenetic angiogenic factor of…
Purpose to develop available physical exercises that increase the effectiveness of therapy in patients with cerebral palsy. Objects and methods.54 patients with cerebral palsy with…
Iron deficiency, iron deficiency conditions and iron deficiency anemia remain a pressing problem worldwide, despite enormous advances in understanding the mechanisms of iron metabolism over the past 20 years. Absorbed…
Target. To stude the role of physical culture in children`s cerebral palse. We examined 62 sick children with cerebral palse. All the sick children were divided info two groups: basic and control. In…
In order to study the morphological characteristics of coronarocardiosclerosis in the elderly, microscopic examination of the hearts of 24 deceased persons aged 60-74 years was performed. In the myocardium…
In the article, it is written in detail that neuroinfections are one of the leading children's infectious diseases, and after neuroinfections, unpleasant consequences occur in half of children, that is, disability with…
Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali — barcha maqolalar