The significance of bdnf in the development of ischemic stroke in young people

KIM Olga Anatolevna

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2024-yil

Annotatsiya

Purpose: to study the relationship between the level of brain-derived neurotrophic factor and the incidence of acute ischemic stroke in young people. Materials and methods: The study included 83 patients aged 22-44 years (main group) who had suffered acute ischemic stroke (males - 41 (49.4%), females 42 (50.6%); average age 38.71±6.5 years). The control group consisted of 54 practically healthy individuals, comparable in age and gender (males 31 (57,4%), females 23 (42,6%); average age 38,59±6,64 years. Quantitative determination of brain-derived neurotrophic factor (BDNF) was carried out using enzyme-linked immunosorbent assay. Results: A careful study of the data presented in the above table revealed an inverse correlation between the concentration of the biomarker and the severity of the disease and the severity of neurological symptoms. In patients with a mild degree of neurological impairment according to the NIHSS scale, we observed a high concentration of serum BDNF and, conversely, a decrease in its level was determined in patients with an extremely severe degree of neurological deficit (r=-0,137, p<0,05). When conducting an intragroup analysis of the quantitative determination of serum BDNF in patients, depending on the pathogenetic subtype of IS, a relationship was established between the level of neurotrophin and the severity of neurological disorders, while the lowest level of this biomarker was observed in patients with hemodynamic stroke. Conclusion: Patients with the lowest BDNF values have an increased risk of unfavorable outcome of ischemic stroke and a low level of rehabilitation potential, while increased levels of this marker in the brain contribute to the restoration of lost functions.

Maqola ma’lumotlari
MualliflarKIM Olga Anatolevna
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2024-04-14
Jild9
Son1
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

ишемический инсульт, молодой возраст, патогенетические подтипы, мозговой нейротрофический фактор, NIHSS, ischemic stroke, young age, pathogenetic subtypes, brain-derived neurotrophic factor, NIHSS., ishemik insult, yoshlar, patogenetik subtiplar, miya neyrotrofik omil, NIHSS

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAKIM Olga Anatolevna (2024). THE SIGNIFICANCE OF BDNF IN THE DEVELOPMENT OF ISCHEMIC STROKE IN YOUNG PEOPLE. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 9(1). https://tadqiqot.uz/index.php/biomedicine/article/view/9270
GOST (OAK)KIM Olga Anatolevna THE SIGNIFICANCE OF BDNF IN THE DEVELOPMENT OF ISCHEMIC STROKE IN YOUNG PEOPLE // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2024. – T. 9, № 1.
MLAKIM Olga Anatolevna. “THE SIGNIFICANCE OF BDNF IN THE DEVELOPMENT OF ISCHEMIC STROKE IN YOUNG PEOPLE.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 9(1), 2024. https://tadqiqot.uz/index.php/biomedicine/article/view/9270
ChicagoKIM Olga Anatolevna. “THE SIGNIFICANCE OF BDNF IN THE DEVELOPMENT OF ISCHEMIC STROKE IN YOUNG PEOPLE.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 9(1) (2024). https://tadqiqot.uz/index.php/biomedicine/article/view/9270
HarvardKIM Olga Anatolevna (2024) ‘THE SIGNIFICANCE OF BDNF IN THE DEVELOPMENT OF ISCHEMIC STROKE IN YOUNG PEOPLE’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 9(1). https://tadqiqot.uz/index.php/biomedicine/article/view/9270
BibTeX
@article{kimolgaanatolevna2024,
  title = {THE SIGNIFICANCE OF BDNF IN THE DEVELOPMENT OF ISCHEMIC STROKE IN YOUNG PEOPLE},
  author = {KIM Olga Anatolevna},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2024},
  volume = {9},
  number = {1},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/9270}
}

Boshqa maqola uchun iqtibos tayyorlash

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali jurnalidan boshqa maqolalar

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali — barcha maqolalar · 2024-yil arxivi

KIM Olga Anatolevna — boshqa maqolalari

Tibbiyot sohasidagi boshqa maqolalar

Tibbiyot sohasidagi OAK jurnallari