The role of urinary biomarkers in the prediction of tubulointerstitial kidney injury in children following COVID-19

Gapparova , Guli

Жанубий оролбўйи тиббиёт журнали · 2026-yil

Annotatsiya

The COVID-19 pandemic has demonstrated the vulnerability of the kidneys as target organs due to high ACE2 expression in renal tubular epithelial cells. The aim of this study was to develop a diagnostic and prognostic approach for pediatric acute pyelonephritis based on the assessment of urinary biomarkers of kidney injury. A total of 100 children aged 7–17 years with acute pyelonephritis were included and divided into two groups according to previous COVID-19 history, along with 25 clinically healthy children as a control group. All participants underwent urinalysis, and measurement of urinary KIM-1, NGAL, β₂-microglobulin, and L-FABP levels. Children with a history of SARS-CoV-2 infection showed significantly elevated urinary biomarker levels and more pronounced subclinical signs of tubulointerstitial injury, including leukocyturia, microhematuria, proteinuria, as well as reduced titratable acidity and ammonia excretion (p<0.001). These findings indicate predominant tubulointerstitial kidney damage even in the absence of clinical manifestations. Early assessment of urinary biomarkers is essential for timely diagnosis and optimization of patient management.

Maqola ma’lumotlari
MualliflarGapparova , Guli
JurnalЖанубий оролбўйи тиббиёт журнали
NashriyotТТА Урганч филиали
ISSN3093-8740, 2012-2021
Nashr sanasi2026-07-27
Jild2
Son3/1
Betlar266-274
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

acute pyelonephritis, children, COVID-19, KIM-1, NGAL

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAGapparova , Guli (2026). THE ROLE OF URINARY BIOMARKERS IN THE PREDICTION OF TUBULOINTERSTITIAL KIDNEY INJURY IN CHILDREN FOLLOWING COVID-19. Жанубий оролбўйи тиббиёт журнали, 2(3/1), 266-274. http://journal.urdti.uz/index/article/view/798
GOST (OAK)Gapparova , Guli THE ROLE OF URINARY BIOMARKERS IN THE PREDICTION OF TUBULOINTERSTITIAL KIDNEY INJURY IN CHILDREN FOLLOWING COVID-19 // Жанубий оролбўйи тиббиёт журнали. – 2026. – T. 2, № 3/1. – P. 266-274.
MLAGapparova , Guli. “THE ROLE OF URINARY BIOMARKERS IN THE PREDICTION OF TUBULOINTERSTITIAL KIDNEY INJURY IN CHILDREN FOLLOWING COVID-19.” Жанубий оролбўйи тиббиёт журнали, 2(3/1), 266-274, 2026. http://journal.urdti.uz/index/article/view/798
ChicagoGapparova , Guli. “THE ROLE OF URINARY BIOMARKERS IN THE PREDICTION OF TUBULOINTERSTITIAL KIDNEY INJURY IN CHILDREN FOLLOWING COVID-19.” Жанубий оролбўйи тиббиёт журнали, 2(3/1), 266-274 (2026). http://journal.urdti.uz/index/article/view/798
HarvardGapparova , Guli (2026) ‘THE ROLE OF URINARY BIOMARKERS IN THE PREDICTION OF TUBULOINTERSTITIAL KIDNEY INJURY IN CHILDREN FOLLOWING COVID-19’, Жанубий оролбўйи тиббиёт журнали, 2(3/1), 266-274. http://journal.urdti.uz/index/article/view/798
BibTeX
@article{gapparovaguli2026,
  title = {THE ROLE OF URINARY BIOMARKERS IN THE PREDICTION OF TUBULOINTERSTITIAL KIDNEY INJURY IN CHILDREN FOLLOWING COVID-19},
  author = {Gapparova , Guli},
  journal = {Жанубий оролбўйи тиббиёт журнали},
  year = {2026},
  volume = {2},
  number = {3/1},
  pages = {266-274},
  url = {http://journal.urdti.uz/index/article/view/798}
}

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