Correction of microbiota changes in patients with chronic kidney failure in Khorezm region

Mansurbekov , Dadakhon, Abdullayev , Ravshanbek, Bakhtiyarova , Aziza

Жанубий оролбўйи тиббиёт журнали · 2026-yil

Annotatsiya

Chronic kidney disease (CKD) is associated with gut microbiota dysbiosis, which exacerbates disease progression through increased production of uremic toxins and systemic inflammation. The Khorezm region presents unique dietary and environmental factors influencing microbiota composition. To review current literature on microbiota alterations in CKD, evaluate therapeutic interventions, and present clinical observations on microbiota correction in CKD patients from the Khorezm region. Literature review combined with a prospective observational study of 30 CKD patients (stages 3–5) receiving probiotic and dietary interventions. Literature confirms dysbiosis characterized by decreased SCFA-producing bacteria and increased proteolytic species. Clinical observations showed that 12 weeks of probiotic and prebiotic supplementation combined with dietary fiber increase resulted in significant reduction of serum uremic toxins (indoxyl sulfate, p-cresyl sulfate), inflammatory markers (CRP, IL-6), and improvement in gastrointestinal symptoms. Targeted microbiota correction is effective in improving biochemical and clinical parameters in CKD patients in Khorezm. Larger controlled studies are recommended

Maqola ma’lumotlari
MualliflarMansurbekov , Dadakhon, Abdullayev , Ravshanbek, Bakhtiyarova , Aziza
JurnalЖанубий оролбўйи тиббиёт журнали
NashriyotТТА Урганч филиали
ISSN3093-8740, 2012-2021
Nashr sanasi2026-02-16
Jild1
Son1
Betlar92-95
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

chronic kidney disease, gut microbiota, probiotics, synbiotics, uremic toxins

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAMansurbekov , Dadakhon, Abdullayev , Ravshanbek, & Bakhtiyarova , Aziza (2026). CORRECTION OF MICROBIOTA CHANGES IN PATIENTS WITH CHRONIC KIDNEY FAILURE IN KHOREZM REGION. Жанубий оролбўйи тиббиёт журнали, 1(1), 92-95. http://journal.urdti.uz/index/article/view/337
GOST (OAK)Mansurbekov , Dadakhon, Abdullayev , Ravshanbek, Bakhtiyarova , Aziza CORRECTION OF MICROBIOTA CHANGES IN PATIENTS WITH CHRONIC KIDNEY FAILURE IN KHOREZM REGION // Жанубий оролбўйи тиббиёт журнали. – 2026. – T. 1, № 1. – P. 92-95.
MLAMansurbekov , Dadakhon, Abdullayev , Ravshanbek, and Bakhtiyarova , Aziza. “CORRECTION OF MICROBIOTA CHANGES IN PATIENTS WITH CHRONIC KIDNEY FAILURE IN KHOREZM REGION.” Жанубий оролбўйи тиббиёт журнали, 1(1), 92-95, 2026. http://journal.urdti.uz/index/article/view/337
ChicagoMansurbekov , Dadakhon, Abdullayev , Ravshanbek, and Bakhtiyarova , Aziza. “CORRECTION OF MICROBIOTA CHANGES IN PATIENTS WITH CHRONIC KIDNEY FAILURE IN KHOREZM REGION.” Жанубий оролбўйи тиббиёт журнали, 1(1), 92-95 (2026). http://journal.urdti.uz/index/article/view/337
HarvardMansurbekov , Dadakhon, Abdullayev , Ravshanbek, and Bakhtiyarova , Aziza (2026) ‘CORRECTION OF MICROBIOTA CHANGES IN PATIENTS WITH CHRONIC KIDNEY FAILURE IN KHOREZM REGION’, Жанубий оролбўйи тиббиёт журнали, 1(1), 92-95. http://journal.urdti.uz/index/article/view/337
BibTeX
@article{mansurbekovdadakhon2026,
  title = {CORRECTION OF MICROBIOTA CHANGES IN PATIENTS WITH CHRONIC KIDNEY FAILURE IN KHOREZM REGION},
  author = {Mansurbekov , Dadakhon and Abdullayev , Ravshanbek and Bakhtiyarova , Aziza},
  journal = {Жанубий оролбўйи тиббиёт журнали},
  year = {2026},
  volume = {1},
  number = {1},
  pages = {92-95},
  url = {http://journal.urdti.uz/index/article/view/337}
}

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