Clinical significance of tumor-infiltrating lymphocytes in breast cancer

ALIMKHODZHAYEVA Lola Telmanovna, НОРБЕКОВА Мунира Хамракуловна, ZIEVIDINOVA Soniya Saidalievna, MIRZAYEVA Matlyuba Akbaralievna, KHUSANOVA Makhinabonu Jamolidinovna

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2023-yil

Annotatsiya

Tumor infiltrating lymphocytes (TILs) play an important role in mediating response to chemotherapy and improving clinical outcomes in all breast cancer subtypes. Triple-negative breast cancer (TN) most likely has tumors with >50% lymphocytic infiltration, termed lymphocyte-dominated breast cancer, and gains the greatest survival advantage for each 10% increase in TIL. Most HER2+ breast cancers have the same level of immune infiltrate as TN breast cancer, but the presence of TIL has not shown the same survival benefit. For breast cancer, HER2+ type 1 T cells, either increased TBET+ tumor infiltration or increased numbers of HER2-specific CD4+ type 1 T cells in peripheral blood are associated with better outcomes. Hormonal receptor-positive HER2-negative tumors tend to have the least immune infiltrate, but are the only subtype of breast cancer that has a poorer prognosis with an increased infiltrate of FOXP3 regulatory T cells. Notably, all breast cancer subtypes have tumors with low, moderate, or high TIL infiltrate. High TIL tumors may also have overexpression of PD-L1, which may be why TN breast cancer appears to show the strongest clinical response to immune checkpoint inhibitor therapy, but further research is needed. On the other hand, tumors with moderate or low levels of immune infiltrate prior to treatment may benefit from an intervention that can increase TIL, especially type 1 T cells. Examples of such interventions include certain types of cytotoxic chemotherapy, radiation therapy, or vaccine therapy. Thus, a systematic assessment of TILs and specific TIL populations can help both in determining prognosis and appropriate sequencing of breast cancer treatment.

Maqola ma’lumotlari
MualliflarALIMKHODZHAYEVA Lola Telmanovna, НОРБЕКОВА Мунира Хамракуловна, ZIEVIDINOVA Soniya Saidalievna, MIRZAYEVA Matlyuba Akbaralievna, KHUSANOVA Makhinabonu Jamolidinovna
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2023-11-01
Jild8
Son4
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

рак молочной железы, инфильтрирующие опухоль лимфоциты, CD8 T-клетки, FOXP3, breast cancer, tumor infiltrating lymphocytes, CD8 T cells, FOXP3

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAALIMKHODZHAYEVA Lola Telmanovna, НОРБЕКОВА Мунира Хамракуловна, ZIEVIDINOVA Soniya Saidalievna, MIRZAYEVA Matlyuba Akbaralievna, & KHUSANOVA Makhinabonu Jamolidinovna (2023). CLINICAL SIGNIFICANCE OF TUMOR-INFILTRATING LYMPHOCYTES IN BREAST CANCER. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 8(4). https://tadqiqot.uz/index.php/biomedicine/article/view/8254
GOST (OAK)ALIMKHODZHAYEVA Lola Telmanovna va b. CLINICAL SIGNIFICANCE OF TUMOR-INFILTRATING LYMPHOCYTES IN BREAST CANCER // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2023. – T. 8, № 4.
MLAALIMKHODZHAYEVA Lola Telmanovna, НОРБЕКОВА Мунира Хамракуловна, ZIEVIDINOVA Soniya Saidalievna, MIRZAYEVA Matlyuba Akbaralievna, and KHUSANOVA Makhinabonu Jamolidinovna. “CLINICAL SIGNIFICANCE OF TUMOR-INFILTRATING LYMPHOCYTES IN BREAST CANCER.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 8(4), 2023. https://tadqiqot.uz/index.php/biomedicine/article/view/8254
ChicagoALIMKHODZHAYEVA Lola Telmanovna, НОРБЕКОВА Мунира Хамракуловна, ZIEVIDINOVA Soniya Saidalievna, MIRZAYEVA Matlyuba Akbaralievna, and KHUSANOVA Makhinabonu Jamolidinovna. “CLINICAL SIGNIFICANCE OF TUMOR-INFILTRATING LYMPHOCYTES IN BREAST CANCER.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 8(4) (2023). https://tadqiqot.uz/index.php/biomedicine/article/view/8254
HarvardALIMKHODZHAYEVA Lola Telmanovna, НОРБЕКОВА Мунира Хамракуловна, ZIEVIDINOVA Soniya Saidalievna, MIRZAYEVA Matlyuba Akbaralievna, and KHUSANOVA Makhinabonu Jamolidinovna (2023) ‘CLINICAL SIGNIFICANCE OF TUMOR-INFILTRATING LYMPHOCYTES IN BREAST CANCER’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 8(4). https://tadqiqot.uz/index.php/biomedicine/article/view/8254
BibTeX
@article{alimkhodzhayevalolatelmanovna2023,
  title = {CLINICAL SIGNIFICANCE OF TUMOR-INFILTRATING LYMPHOCYTES IN BREAST CANCER},
  author = {ALIMKHODZHAYEVA Lola Telmanovna and НОРБЕКОВА Мунира Хамракуловна and ZIEVIDINOVA Soniya Saidalievna and MIRZAYEVA Matlyuba Akbaralievna and KHUSANOVA Makhinabonu Jamolidinovna},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2023},
  volume = {8},
  number = {4},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/8254}
}

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