Modern aspects of bartter’s syndrome

Akhmedova D.I., Abidova M.D.

Педиатрия · 2026-yil

Annotatsiya

The article provides a comprehensive review of recent advancements in the understanding, diagnosis, and management of Bartter’s syndrome, a rare autosomal recessive tubulopathy characterized by hypokalemic metabolic alkalosis, hyperreninemic hyperaldosteronism, and normal-to-low blood pressure. The authors systematically analyze the genetic and molecular pathophysiology of the disease, emphasizing mutations in genes encoding ion transport proteins in the thick ascending limb of the loop of Henle (e.g., NKCC2, ROMK, CLCNKB, BSND, and CLCNKA). The review highlights how these mutations disrupt electrolyte reabsorption, leading to the clinical manifestations of the syndrome. A significant portion of the article is dedicated to the classification of Bartter’s syndrome into distinct subtypes based on genetic defects and phenotypic variability. The authors discuss the challenges in differential diagnosis, particularly in distinguishing Bartter’s syndrome from other electrolyte disorders such as Gitelman syndrome and pseudo-Bartter’s syndrome. Modern diagnostic approaches, including next-generation sequencing and biochemical profiling, are critically evaluated for their accuracy and accessibility. Therapeutic strategies are thoroughly reviewed, with an emphasis on personalized treatment, including potassium-sparing diuretics, NSAIDs (to counteract prostaglandin- mediated hyperreninemia), and electrolyte supplementation. The article also explores emerging therapies, such as targeted molecular interventions, though acknowledges the need for further research. Overall, this review is a valuable resource for clinicians and researchers, offering an up-to-date synthesis of genetic, diagnostic, and therapeutic advancements in Bartter’s syndrome. However, the authors note that despite progress, long-term outcomes and optimal management protocols remain areas requiring further investigation. The article underscores the importance of early diagnosis and multidisciplinary care in improving patient prognosis.

Maqola ma’lumotlari
MualliflarAkhmedova D.I., Abidova M.D.
JurnalПедиатрия
NashriyotТошкент педиатрия тиббиёт институти
Nashr sanasi2026-07-31
Son1
Betlar72-86
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

Bartter’s syndrome, hypokalemic metabolic alkalosis, autosomal recessive tubulopathy, loop of Henle transporters, genetic mutations, differential diagnosis, electrolyte management, NSAIDs

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAAkhmedova D.I., Abidova M.D. (2026). MODERN ASPECTS OF BARTTER’S SYNDROME. Педиатрия, (1), 72-86. https://journals.tnmu.uz/index.php/pspj/article/view/5981
GOST (OAK)Akhmedova D.I., Abidova M.D. MODERN ASPECTS OF BARTTER’S SYNDROME // Педиатрия. – 2026. – № 1. – P. 72-86.
MLAAkhmedova D.I., Abidova M.D. “MODERN ASPECTS OF BARTTER’S SYNDROME.” Педиатрия, (1), 72-86, 2026. https://journals.tnmu.uz/index.php/pspj/article/view/5981
ChicagoAkhmedova D.I., Abidova M.D. “MODERN ASPECTS OF BARTTER’S SYNDROME.” Педиатрия, (1), 72-86 (2026). https://journals.tnmu.uz/index.php/pspj/article/view/5981
HarvardAkhmedova D.I., Abidova M.D (2026) ‘MODERN ASPECTS OF BARTTER’S SYNDROME’, Педиатрия, (1), 72-86. https://journals.tnmu.uz/index.php/pspj/article/view/5981
BibTeX
@article{akhmedovadiabidovamd2026,
  title = {MODERN ASPECTS OF BARTTER’S SYNDROME},
  author = {Akhmedova D.I., Abidova M.D.},
  journal = {Педиатрия},
  year = {2026},
  number = {1},
  pages = {72-86},
  url = {https://journals.tnmu.uz/index.php/pspj/article/view/5981}
}

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