In animals with experimental hypercholesterolemia, depending on the time of survey, we observed activation of smooth muscle cells and macrophages, causing development of inflammation in the intima, as evidenced by high levels of C-reactive protein (CRP), endothelin-1, and homocysteine. The aim of the study was to investigate the molecular mechanisms of endothelial dysfunction in HCH and the possibility of their correction with sulfaporin. Material and methods of the study Experiments were conducted on 46 Chinchilla rabbits with an average weight of 2.5–3.0 kg, kept on a standard diet. The model of experimental HCH in animals was reproduced by orally administering cholesterol (CS) dissolved in sunflower oil in a ratio of 0.2 g per 1 kg of body weight daily for 3 months. The development of hypercholesterolemia was assessed by the increase in the level of totalcholesterol (TC), low-density lipoproteins (LDL) and high-density lipoproteins (HDL), which were determined on a biochemical analyzer. Results of the study. In this case, a progressive increase in the homocysteine level was established: an increase of 1.72 (P < 0.01); 2.33 (P < 0.001) and 2.89 (P < 0.001) times, respectively, for the periods of cholesterol administration of 1, 2 and 3 months. Considering that hyperhomocysteinemia enhances the capture of LDL by endothelial cells, it was of interest to study the relationship between these indicators. The studies showed that with a cholesterol level in LDL of 2.38 ± 0.27 mmol / l, the homocysteine content is 3.46 ± 0.25 pg / ml. With a cholesterol level in LDL of 4.08 ± 0.10; 5.97 ± 0.09 and 6.48 ± 0.11 mmol/l, the homocysteine content increases to 5.96 ± 0.05; 8.07 ± 0.43 and 9.99 ± 0.17 pg/ml, respectively. Conclusions. Hypercholesterolemia is manifested by activation of smooth muscle cells and macrophages, causing the development of inflammation in the intima, which is confirmed by high levels of CRP, endothelin-1, homocysteine.
| Mualliflar | Qutlikova , Go'zalxon, Кутликова , Гузалхон, Qutlikova , Go'zalxon |
|---|---|
| Jurnal | Халқаро илмий педиатрия журнали |
| Nashr sanasi | 2024-11-15 |
| Jild | 3 |
| Son | 8 |
| Betlar | 704-709 |
| Til | Ingliz |
| DOI | 10.56121/2181-2926-2024-3-8-704-709 |
DOI: 10.56121/2181-2926-2024-3-8-704-709 · Maqolaning asl sahifasi
гиперхолестеринемия, С-реактивный белок, эндотелин-1, гомоцистеин, лечение, hypercholesterolemia, C-reactive protein, endothelin-1, homocysteine, treatment, giperkolesterolemiya, C-reaktiv oqsil, endotelin-1, homosistein, davolash
The increasing prevalence of cardiovascular diseases in adults underscores the critical need for timely diagnosis of cardiovascular risk factors. Abdominal obesity during childhood and adolescence has been identified as…
This review article discusses methodological approaches to the rational use of herbal medicines for the treatment of respiratory diseases. The causes and mechanisms of cough are considered.. The mechanisms of action of…
This article provides a comprehensive review of the pathogenesis and clinical manifestations of dental developmental disorders, which present significant challenges in modern dentistry. It examines the mechanisms…
To study the frequency of such risk factors for cardiovascular diseases as hypertension, overweight/obesity, type 2 diabetes, smoking in men and women in different age groups. Materials and methods of the study. The…
This review article is devoted to the most important section of neonatal pulmonology, non-infectious (pneumopathy) lung pathology. Improving the organization of medical and preventive care for newborns and reducing…
This article presents historical and modern ideas about the role of temperament in psychosomatic relationships. The evolution and origins of the study of temperament and the origins of the formation of psychosomatic…
Complex pathophysiological changes in the maternal-placental, fetal-infant system are reflected in a number of diseases of the perinatal period, in particular, this concerns hemolytic disease of the newborn. This review…
The relevance of studying the personality characteristics of children with vegetovascular dystonia (VVD) is dictated by the fact that many psychosomatic disorders originate in childhood and autonomic disorders are their…
The relevance of iron deficiency anemia is determined not only by its wide prevalence, but also in connection with the development of polysystemic disorders, dystrophy of internal organs, which is often associated with…
The purpose of the study is to assess the physical development and level of maturity of schoolgirls and teenage girls involved in sports. The main goal of the study is to study the impact of sports on the physical…