Cyclin B1 expression in mothers of down syndrome versus euploid children

Fabian Layton Tovar, Cristian, Consuelo Hinojosa Juárez, Araceli, Garduño Alanís, Adriana, Adriana Pérez González, Edith, Mendieta Zerón, Hugo, Фабиан Лейтон Товар, Кристиан, Консуэло Инохоса Хуарес, Арасели, Гардуньо Аланис, Адриана, Адриана Перес Гонсалес, Эдит, Мендьета Серон, Уго, Fabian Layton Tovar, Cristian, Consuelo Hinojosa Juárez, Araceli, Garduño Alanís, Adriana, Adriana Pérez González, Edith, Mendieta Zerón, Hugo

Халқаро илмий педиатрия журнали · 2024-yil

Annotatsiya

Introduction. Down Syndrome (DS) is the most common chromosomopathy. Cyclin B1 is a regulatory protein involved in mitosis. The aim was to determine the cyclin B1 relative expression in mothers of DS patients. Methods. In this cross-sectional study, mononuclear cells of peripheral blood were obtained from 40 mothers of confirmed DS patients and 40 mothers of euploid patients, between 2019-2021. Demographic variables and cyclin B1 messenger RNA (mRNA) with real-time polymerase chain reaction (qPCR) were analyzed. The cases of DS mothers were compared to the relative expression of euploid group. Results. cyclin B1 mean relative expression by RT-PCR showed a significant difference between the group of mothers of DS children and mothers of euploid children (p < 0.05). The expression of the cyclin B1 was lower than the mean of mothers with euploid patients. Previously, it has been reported that the cyclin B1 down expression should accelerate telomere shortening in DS patients. Therefore, it would be advisable to recategorize the maternal age-related risk factor. Conclusion. Cyclin B1 may be a cost-effective biomarker in reproductive age women to present a DS case not associated with chronological age.

Maqola ma’lumotlari
MualliflarFabian Layton Tovar, Cristian, Consuelo Hinojosa Juárez, Araceli, Garduño Alanís, Adriana, Adriana Pérez González, Edith, Mendieta Zerón, Hugo, Фабиан Лейтон Товар, Кристиан, Консуэло Инохоса Хуарес, Арасели, Гардуньо Аланис, Адриана, Адриана Перес Гонсалес, Эдит, Мендьета Серон, Уго, Fabian Layton Tovar, Cristian, Consuelo Hinojosa Juárez, Araceli, Garduño Alanís, Adriana, Adriana Pérez González, Edith, Mendieta Zerón, Hugo
JurnalХалқаро илмий педиатрия журнали
NashriyotАндижон давлат тиббиёт институти; In Science МЧЖ
ISSN2181-2926, 2181-2926
Nashr sanasi2024-02-29
Jild3
Son2
Betlar479-484
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/2181-2926-2024-3-2-479-484
Indeksga qo‘shilgan2026-08-26

DOI: 10.56121/2181-2926-2024-3-2-479-484 · Maqolaning asl sahifasi

Kalit so‘zlar

биомаркер, циклин В1, синдром Дауна, фактор риска, biomarker,, cyclin B1, Down Syndrome, risk factor, biomarker, siklin B1, Daun sindromi, xavf omili

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAFabian Layton Tovar, Cristian, Consuelo Hinojosa Juárez, Araceli, Garduño Alanís, Adriana, Adriana Pérez González, Edith, Mendieta Zerón, Hugo, Фабиан Лейтон Товар, Кристиан, Консуэло Инохоса Хуарес, Арасели, Гардуньо Аланис, Адриана, Адриана Перес Гонсалес, Эдит, Мендьета Серон, Уго, Fabian Layton Tovar, Cristian, Consuelo Hinojosa Juárez, Araceli, Garduño Alanís, Adriana, Adriana Pérez González, Edith, & Mendieta Zerón, Hugo (2024). CYCLIN B1 EXPRESSION IN MOTHERS OF DOWN SYNDROME VERSUS EUPLOID CHILDREN. Халқаро илмий педиатрия журнали, 3(2), 479-484. https://doi.org/10.56121/2181-2926-2024-3-2-479-484
GOST (OAK)Fabian Layton Tovar, Cristian va b. CYCLIN B1 EXPRESSION IN MOTHERS OF DOWN SYNDROME VERSUS EUPLOID CHILDREN // Халқаро илмий педиатрия журнали. – 2024. – T. 3, № 2. – P. 479-484. – DOI: 10.56121/2181-2926-2024-3-2-479-484.
MLAFabian Layton Tovar, Cristian, Consuelo Hinojosa Juárez, Araceli, Garduño Alanís, Adriana, Adriana Pérez González, Edith, Mendieta Zerón, Hugo, Фабиан Лейтон Товар, Кристиан, Консуэло Инохоса Хуарес, Арасели, Гардуньо Аланис, Адриана, Адриана Перес Гонсалес, Эдит, Мендьета Серон, Уго, Fabian Layton Tovar, Cristian, Consuelo Hinojosa Juárez, Araceli, Garduño Alanís, Adriana, Adriana Pérez González, Edith, and Mendieta Zerón, Hugo. “CYCLIN B1 EXPRESSION IN MOTHERS OF DOWN SYNDROME VERSUS EUPLOID CHILDREN.” Халқаро илмий педиатрия журнали, 3(2), 479-484, 2024. https://doi.org/10.56121/2181-2926-2024-3-2-479-484
ChicagoFabian Layton Tovar, Cristian, Consuelo Hinojosa Juárez, Araceli, Garduño Alanís, Adriana, Adriana Pérez González, Edith, Mendieta Zerón, Hugo, Фабиан Лейтон Товар, Кристиан, Консуэло Инохоса Хуарес, Арасели, Гардуньо Аланис, Адриана, Адриана Перес Гонсалес, Эдит, Мендьета Серон, Уго, Fabian Layton Tovar, Cristian, Consuelo Hinojosa Juárez, Araceli, Garduño Alanís, Adriana, Adriana Pérez González, Edith, and Mendieta Zerón, Hugo. “CYCLIN B1 EXPRESSION IN MOTHERS OF DOWN SYNDROME VERSUS EUPLOID CHILDREN.” Халқаро илмий педиатрия журнали, 3(2), 479-484 (2024). https://doi.org/10.56121/2181-2926-2024-3-2-479-484
HarvardFabian Layton Tovar, Cristian, Consuelo Hinojosa Juárez, Araceli, Garduño Alanís, Adriana, Adriana Pérez González, Edith, Mendieta Zerón, Hugo, Фабиан Лейтон Товар, Кристиан, Консуэло Инохоса Хуарес, Арасели, Гардуньо Аланис, Адриана, Адриана Перес Гонсалес, Эдит, Мендьета Серон, Уго, Fabian Layton Tovar, Cristian, Consuelo Hinojosa Juárez, Araceli, Garduño Alanís, Adriana, Adriana Pérez González, Edith, and Mendieta Zerón, Hugo (2024) ‘CYCLIN B1 EXPRESSION IN MOTHERS OF DOWN SYNDROME VERSUS EUPLOID CHILDREN’, Халқаро илмий педиатрия журнали, 3(2), 479-484. https://doi.org/10.56121/2181-2926-2024-3-2-479-484
BibTeX
@article{fabianlaytontovarcristian2024,
  title = {CYCLIN B1 EXPRESSION IN MOTHERS OF DOWN SYNDROME VERSUS EUPLOID CHILDREN},
  author = {Fabian Layton Tovar, Cristian and Consuelo Hinojosa Juárez, Araceli and Garduño Alanís, Adriana and Adriana Pérez González, Edith and Mendieta Zerón, Hugo and Фабиан Лейтон Товар, Кристиан and Консуэло Инохоса Хуарес, Арасели and Гардуньо Аланис, Адриана and Адриана Перес Гонсалес, Эдит and Мендьета Серон, Уго and Fabian Layton Tovar, Cristian and Consuelo Hinojosa Juárez, Araceli and Garduño Alanís, Adriana and Adriana Pérez González, Edith and Mendieta Zerón, Hugo},
  journal = {Халқаро илмий педиатрия журнали},
  year = {2024},
  volume = {3},
  number = {2},
  pages = {479-484},
  doi = {10.56121/2181-2926-2024-3-2-479-484},
  url = {https://doi.org/10.56121/2181-2926-2024-3-2-479-484}
}

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