Introduction. Down Syndrome (DS) is the most common chromosomopathy. Cyclin B1 is a regulatory protein involved in mitosis. The aim was to determine the cyclin B1 relative expression in mothers of DS patients. Methods. In this cross-sectional study, mononuclear cells of peripheral blood were obtained from 40 mothers of confirmed DS patients and 40 mothers of euploid patients, between 2019-2021. Demographic variables and cyclin B1 messenger RNA (mRNA) with real-time polymerase chain reaction (qPCR) were analyzed. The cases of DS mothers were compared to the relative expression of euploid group. Results. cyclin B1 mean relative expression by RT-PCR showed a significant difference between the group of mothers of DS children and mothers of euploid children (p < 0.05). The expression of the cyclin B1 was lower than the mean of mothers with euploid patients. Previously, it has been reported that the cyclin B1 down expression should accelerate telomere shortening in DS patients. Therefore, it would be advisable to recategorize the maternal age-related risk factor. Conclusion. Cyclin B1 may be a cost-effective biomarker in reproductive age women to present a DS case not associated with chronological age.
| Mualliflar | Fabian Layton Tovar, Cristian, Consuelo Hinojosa Juárez, Araceli, Garduño Alanís, Adriana, Adriana Pérez González, Edith, Mendieta Zerón, Hugo, Фабиан Лейтон Товар, Кристиан, Консуэло Инохоса Хуарес, Арасели, Гардуньо Аланис, Адриана, Адриана Перес Гонсалес, Эдит, Мендьета Серон, Уго, Fabian Layton Tovar, Cristian, Consuelo Hinojosa Juárez, Araceli, Garduño Alanís, Adriana, Adriana Pérez González, Edith, Mendieta Zerón, Hugo |
|---|---|
| Jurnal | Халқаро илмий педиатрия журнали |
| Nashr sanasi | 2024-02-29 |
| Jild | 3 |
| Son | 2 |
| Betlar | 479-484 |
| Til | Ingliz |
| DOI | 10.56121/2181-2926-2024-3-2-479-484 |
DOI: 10.56121/2181-2926-2024-3-2-479-484 · Maqolaning asl sahifasi
биомаркер, циклин В1, синдром Дауна, фактор риска, biomarker,, cyclin B1, Down Syndrome, risk factor, biomarker, siklin B1, Daun sindromi, xavf omili
Summary: This review presents the results of scientific work devoted to the study of biochemical markers of liver damage in respiratory allergies. It has been established that with respiratory allergies in children…
Annotation.This review article is devoted to the current problem of pediatric and adolescent cardiology - congenital heart defects in children. Based on extensive modern domestic and foreign literature, issues of…
Effective strategies for the prevention of acute laryngitis in children are an important topic in modern medicine. This review addresses current approaches and innovations in the prevention of this disease. Various…
Abstract: The health status of children worsens over the years of schooling; the creation of health and rehabilitation programs for students remains especially relevant. This review article is devoted to one of the…
The relevance of studying the pathogenesis of childhood rhinosinusitis is highlighted in modern medical practice. This abstract is a literature review highlighting modern aspects of this problem. Rhinosinusitis…
Abstract: In recent years, evidence has emerged of a strong relationship between obesity and mental illness, which affects all aspects of a person’s quality of life. The purpose of this work was to study the quality of…
Preeclampsia, one of the “life-threatening obstetric syndromes,” complicates approximately 2–7% of pregnancies and is considered a leading cause of maternal and perinatal morbidity and mortality worldwide. Purpose of…
Abstract. The goal of the study was optimization noninvasive methods of diagnosis in acute scrotum syndrome in children. Material: the results of treatment of children aged 1 to 18 years with acute scrotal…
This article discusses the causes and predisposing factors leading to preeclampsia (PE), using the example of the regional perinatal center of the Syrdarya region of Uzbekistan for the period 2020-2022. The purpose of…
Abstract: Currently, in healthcare around the world, including Uzbekistan, the gold standard for surgical treatment of combined diseases of the abdominal organ proved to be simultaneous operations using…