The role of IL-4 and TLR6 gene polymorphism in patients with bronchial asthma with allergic rhinitis

Azizova, Nigora, Zokirov, Botirzhon, Азизова, Нигора, Зокиров, Ботиржон, Azizova, Nigora, Zokirov, Botirjon

Халқаро илмий педиатрия журнали · 2023-yil

Annotatsiya

Relevance. As is known, the occurrence of chronic diseases, such as bronchial asthma, requires a combined effect of genetic and environmental factors. At the same time, the influence of genetic predictors on the course of recurrent bronchitis in children is not excluded. The aim of the study was to study the role of IL-4 and TLR6 gene polymorphisms in patients with bronchial asthma with allergic rhinitis. Material and methods. We have studied the clinical course of bronchial asthma occurring in patients with allergic rhinitis. The observation was carried out in 130 children aged 7 to 14 years. The main group consisted of 105 people. The comparison group consisted of 45 children with allergic rhinitis with bronchial asthma and 45 children of the Republic of Belarus with biofeedback + AR. The studies were carried out on a contractual basis in the laboratory "Genotexnologiya" and at the Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of Uzbekistan; cyto-immunological study of immunological parameters (levels of IgA, IgM, IgG, IL-4, TNF-α) in induced sputum (MI), was determined by ELISA (Russia) in the laboratory "Genotexnologiya". Results. The frequency of the unfavorable allele G, determined in the main and control groups, does not statistically significantly differ from each other χ2 = 5.754: p=0.017; OR=2.98; 95% CI 1.19-7.49). As can be seen from the presented data, a significant predominance of the C/T genotype of the C-590T polymorphism of the IL-4 gene in BA children with AR was established (22.2%, respectively, compared to 11.1% in the RB group with BOS + AR; χ2 = 1.31; p=0.4; OR=2.0; 95% CI 0.62-6.45). According to the data of statistical analysis, the association of the T/T genotype with the development of BA with AR in children was proven (χ2 =2.39; p=0.56; OR=4.87; 95%CI 0.54-43.64). Conclusions: as a result, it can be emphasized that the carriage of the polymorphic marker TLR6 745T is a genetic risk factor for the development of RB with BOS and AR, while the presence of a homozygous genotype for the minor allele 745C reduces the risk of developing BA and has protective properties.

Maqola ma’lumotlari
MualliflarAzizova, Nigora, Zokirov, Botirzhon, Азизова, Нигора, Зокиров, Ботиржон, Azizova, Nigora, Zokirov, Botirjon
JurnalХалқаро илмий педиатрия журнали
NashriyotАндижон давлат тиббиёт институти; In Science МЧЖ
ISSN2181-2926, 2181-2926
Nashr sanasi2023-05-31
Jild2
Son5
Betlar18-21
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/2181-2926-2023-5-18-21
Indeksga qo‘shilgan2026-08-26

DOI: 10.56121/2181-2926-2023-5-18-21 · Maqolaning asl sahifasi

Kalit so‘zlar

бронхиальная астма, аллергия, ринит, генотип, воспаления, интерлейкини, воспалительный медиатор, эндокринный регулятор, bronchial asthma, allergy, rhinitis, genotype, inflammation, interleukini, inflammatory mediator, endocrine regulator, bronxial astma, allergiya, rinit, genotip, yallig'lanish, interleykinlar, yallig'lanish vositachisi, endokrin regulyator

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAAzizova, Nigora, Zokirov, Botirzhon, Азизова, Нигора, Зокиров, Ботиржон, Azizova, Nigora, & Zokirov, Botirjon (2023). THE ROLE OF IL-4 AND TLR6 GENE POLYMORPHISM IN PATIENTS WITH BRONCHIAL ASTHMA WITH ALLERGIC RHINITIS. Халқаро илмий педиатрия журнали, 2(5), 18-21. https://doi.org/10.56121/2181-2926-2023-5-18-21
GOST (OAK)Azizova, Nigora va b. THE ROLE OF IL-4 AND TLR6 GENE POLYMORPHISM IN PATIENTS WITH BRONCHIAL ASTHMA WITH ALLERGIC RHINITIS // Халқаро илмий педиатрия журнали. – 2023. – T. 2, № 5. – P. 18-21. – DOI: 10.56121/2181-2926-2023-5-18-21.
MLAAzizova, Nigora, Zokirov, Botirzhon, Азизова, Нигора, Зокиров, Ботиржон, Azizova, Nigora, and Zokirov, Botirjon. “THE ROLE OF IL-4 AND TLR6 GENE POLYMORPHISM IN PATIENTS WITH BRONCHIAL ASTHMA WITH ALLERGIC RHINITIS.” Халқаро илмий педиатрия журнали, 2(5), 18-21, 2023. https://doi.org/10.56121/2181-2926-2023-5-18-21
ChicagoAzizova, Nigora, Zokirov, Botirzhon, Азизова, Нигора, Зокиров, Ботиржон, Azizova, Nigora, and Zokirov, Botirjon. “THE ROLE OF IL-4 AND TLR6 GENE POLYMORPHISM IN PATIENTS WITH BRONCHIAL ASTHMA WITH ALLERGIC RHINITIS.” Халқаро илмий педиатрия журнали, 2(5), 18-21 (2023). https://doi.org/10.56121/2181-2926-2023-5-18-21
HarvardAzizova, Nigora, Zokirov, Botirzhon, Азизова, Нигора, Зокиров, Ботиржон, Azizova, Nigora, and Zokirov, Botirjon (2023) ‘THE ROLE OF IL-4 AND TLR6 GENE POLYMORPHISM IN PATIENTS WITH BRONCHIAL ASTHMA WITH ALLERGIC RHINITIS’, Халқаро илмий педиатрия журнали, 2(5), 18-21. https://doi.org/10.56121/2181-2926-2023-5-18-21
BibTeX
@article{azizovanigora2023,
  title = {THE ROLE OF IL-4 AND TLR6 GENE POLYMORPHISM IN PATIENTS WITH BRONCHIAL ASTHMA WITH ALLERGIC RHINITIS},
  author = {Azizova, Nigora and Zokirov, Botirzhon and Азизова, Нигора and Зокиров, Ботиржон and Azizova, Nigora and Zokirov, Botirjon},
  journal = {Халқаро илмий педиатрия журнали},
  year = {2023},
  volume = {2},
  number = {5},
  pages = {18-21},
  doi = {10.56121/2181-2926-2023-5-18-21},
  url = {https://doi.org/10.56121/2181-2926-2023-5-18-21}
}

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