Reaction of 5-(O-TOLUIDINO, n-butylamino and α- NAPHTHYLAMINO)-1,3,4-THIADIAZOLINE-2-THIONES with maleic anhydride: synthesis and in silico evaluation of biological activity

Razzoqberdiev, Nurbek, Ataniyazov, Otaniyoz, Polvonov, Khudoybergan

Қўқон ДПИ. Илмий хабарлар · 2026-yil

Annotatsiya

Ushbu tadqiqotda 5-o-toluidino-, 5-n-butilamino- va 5-α-naftilamino- 1,3,4-tiadiazolin-2-tionlarning malein angidridi bilan o‘zaro ta’siri o‘rganilib, yangi N-atsil hosilalarni sintez qilish hamda ularning tuzilishini va nazariy jihatdan biologik xususiyatlarini baholash maqsad qilingan. Reaksiyalar trietilamin ishtirokida absolyut benzol erituvchisida xona harorati va 80℃ da amalga oshirildi. Sintez qilingan mahsulotlarining tuzilishi IQ- va UB-Vis spektroskopik tahlillari, fizik-kimyoviy ko‘rsatkichlari asosida tavsiflandi. Sintez qilingan birikmalarning nazariy biologik faolligi PASS dasturi yordamida in silico baholandi. Olingan natijalar 1,3,4-tiadiazolin-2-tion molekulasini malein angidridi bilan atsillash orqali yangi biologik faol birikmalar sintez qilish imkoniyatini yaratib, ularning keyingi tadqiqotlar uchun istiqbolli birikmalar ekanligini ko‘rsatadi.

Maqola ma’lumotlari
MualliflarRazzoqberdiev, Nurbek, Ataniyazov, Otaniyoz, Polvonov, Khudoybergan
JurnalҚўқон ДПИ. Илмий хабарлар
NashriyotҚўқон давлат педагогика институти
ISSN3030-3958
Nashr sanasi2026-10-10
Jild8
Son9
Betlar1003-1013
TilIngliz
DOI10.70728/a.series.tab.v08.i09.133
Indeksga qo‘shilgan2026-10-11

DOI: 10.70728/a.series.tab.v08.i09.133 · Maqolaning asl sahifasi

Kalit so‘zlar

1, 3, 4-tiadiazolin-2-tion, malein angidridi, N-atsil, yupqa qatlamli xromatografiya, trietilamin, IQ-spektroskopiya, UB-Vis spektroskopiya, biologik faollik, PASS, in silico tahlil.

Iqtibos keltirish

APARazzoqberdiev, Nurbek, Ataniyazov, Otaniyoz, & Polvonov, Khudoybergan (2026). REACTION OF 5-(O-TOLUIDINO, N-BUTYLAMINO AND Α- NAPHTHYLAMINO)-1,3,4-THIADIAZOLINE-2-THIONES WITH MALEIC ANHYDRIDE: SYNTHESIS AND IN SILICO EVALUATION OF BIOLOGICAL ACTIVITY. Қўқон ДПИ. Илмий хабарлар, 8(9), 1003-1013. https://doi.org/10.70728/a.series.tab.v08.i09.133
GOST (OAK)Razzoqberdiev, Nurbek, Ataniyazov, Otaniyoz, Polvonov, Khudoybergan REACTION OF 5-(O-TOLUIDINO, N-BUTYLAMINO AND Α- NAPHTHYLAMINO)-1,3,4-THIADIAZOLINE-2-THIONES WITH MALEIC ANHYDRIDE: SYNTHESIS AND IN SILICO EVALUATION OF BIOLOGICAL ACTIVITY // Қўқон ДПИ. Илмий хабарлар. – 2026. – T. 8, № 9. – P. 1003-1013. – DOI: 10.70728/a.series.tab.v08.i09.133.
MLARazzoqberdiev, Nurbek, Ataniyazov, Otaniyoz, and Polvonov, Khudoybergan. “REACTION OF 5-(O-TOLUIDINO, N-BUTYLAMINO AND Α- NAPHTHYLAMINO)-1,3,4-THIADIAZOLINE-2-THIONES WITH MALEIC ANHYDRIDE: SYNTHESIS AND IN SILICO EVALUATION OF BIOLOGICAL ACTIVITY.” Қўқон ДПИ. Илмий хабарлар, 8(9), 1003-1013, 2026. https://doi.org/10.70728/a.series.tab.v08.i09.133
ChicagoRazzoqberdiev, Nurbek, Ataniyazov, Otaniyoz, and Polvonov, Khudoybergan. “REACTION OF 5-(O-TOLUIDINO, N-BUTYLAMINO AND Α- NAPHTHYLAMINO)-1,3,4-THIADIAZOLINE-2-THIONES WITH MALEIC ANHYDRIDE: SYNTHESIS AND IN SILICO EVALUATION OF BIOLOGICAL ACTIVITY.” Қўқон ДПИ. Илмий хабарлар, 8(9), 1003-1013 (2026). https://doi.org/10.70728/a.series.tab.v08.i09.133
HarvardRazzoqberdiev, Nurbek, Ataniyazov, Otaniyoz, and Polvonov, Khudoybergan (2026) ‘REACTION OF 5-(O-TOLUIDINO, N-BUTYLAMINO AND Α- NAPHTHYLAMINO)-1,3,4-THIADIAZOLINE-2-THIONES WITH MALEIC ANHYDRIDE: SYNTHESIS AND IN SILICO EVALUATION OF BIOLOGICAL ACTIVITY’, Қўқон ДПИ. Илмий хабарлар, 8(9), 1003-1013. https://doi.org/10.70728/a.series.tab.v08.i09.133
BibTeX
@article{razzoqberdievnurbek2026,
  title = {REACTION OF 5-(O-TOLUIDINO, N-BUTYLAMINO AND Α- NAPHTHYLAMINO)-1,3,4-THIADIAZOLINE-2-THIONES WITH MALEIC ANHYDRIDE: SYNTHESIS AND IN SILICO EVALUATION OF BIOLOGICAL ACTIVITY},
  author = {Razzoqberdiev, Nurbek and Ataniyazov, Otaniyoz and Polvonov, Khudoybergan},
  journal = {Қўқон ДПИ. Илмий хабарлар},
  year = {2026},
  volume = {8},
  number = {9},
  pages = {1003-1013},
  doi = {10.70728/a.series.tab.v08.i09.133},
  url = {https://doi.org/10.70728/a.series.tab.v08.i09.133}
}

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