Ophthalmic artery doppler and angiogenic biomarkers in the prediction of preeclampsia: current evidence and future perspectives

Kamilova I.A., Khikmatullayeva L.I.

Гуманитар ва табиий фанлар журнали · 2026-yil

Annotatsiya

In this review, current evidence on the pathogenesis, prediction, and potential role of ophthalmic artery Doppler and angiogenic biomarkers in pre-eclampsia is considered. Analysis of the available data indicates that one of the main trends in modern obstetrics is the search for reliable, non-invasive predictors capable of identifying women at increased risk of developing pre-eclampsia before the onset of clinical manifestations. Particular attention is given to ophthalmic artery Doppler parameters, especially the second systolic peak and peak systolic velocity ratio, which may reflect maternal cerebrovascular maladaptation associated with pre-eclampsia. At the same time, angiogenic biomarkers, including placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1), and soluble endoglin (sEng), provide important information about placental and endothelial dysfunction. Current evidence suggests that the most promising direction is a multifactorial approach combining maternal clinical characteristics, Doppler parameters, and angiogenic biomarkers rather than the use of a single predictor. The combined assessment of ophthalmic artery Doppler and soluble endoglin may provide complementary information on maternal vascular and antiangiogenic dysfunction; however, its additional prognostic value has not yet been sufficiently established. Based on the analysis of the available literature, it can be concluded that further prospective studies, standardization of Doppler measurements, simultaneous assessment of biomarkers, and external validation of multimarker models are required before these approaches can be recommended for routine clinical prediction and risk stratification of pre-eclampsia.

Maqola ma’lumotlari
MualliflarKamilova I.A., Khikmatullayeva L.I.
JurnalГуманитар ва табиий фанлар журнали
NashriyotEMU University
ISSN2026-2027, 2181-4007
Nashr sanasi2026-09-14
Son36
Betlar50-57
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-09-14

Maqolaning asl sahifasi

Kalit so‘zlar

pre-eclampsia; ophthalmic artery Doppler; angiogenic biomarkers; soluble endoglin; PlGF; sFlt-1; prediction; risk stratification.

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAKamilova I.A., Khikmatullayeva L.I. (2026). OPHTHALMIC ARTERY DOPPLER AND ANGIOGENIC BIOMARKERS IN THE PREDICTION OF PREECLAMPSIA: CURRENT EVIDENCE AND FUTURE PERSPECTIVES. Гуманитар ва табиий фанлар журнали, (36), 50-57. https://journals.tnmu.uz/index.php/gtfj/article/view/6345
GOST (OAK)Kamilova I.A., Khikmatullayeva L.I. OPHTHALMIC ARTERY DOPPLER AND ANGIOGENIC BIOMARKERS IN THE PREDICTION OF PREECLAMPSIA: CURRENT EVIDENCE AND FUTURE PERSPECTIVES // Гуманитар ва табиий фанлар журнали. – 2026. – № 36. – P. 50-57.
MLAKamilova I.A., Khikmatullayeva L.I. “OPHTHALMIC ARTERY DOPPLER AND ANGIOGENIC BIOMARKERS IN THE PREDICTION OF PREECLAMPSIA: CURRENT EVIDENCE AND FUTURE PERSPECTIVES.” Гуманитар ва табиий фанлар журнали, (36), 50-57, 2026. https://journals.tnmu.uz/index.php/gtfj/article/view/6345
ChicagoKamilova I.A., Khikmatullayeva L.I. “OPHTHALMIC ARTERY DOPPLER AND ANGIOGENIC BIOMARKERS IN THE PREDICTION OF PREECLAMPSIA: CURRENT EVIDENCE AND FUTURE PERSPECTIVES.” Гуманитар ва табиий фанлар журнали, (36), 50-57 (2026). https://journals.tnmu.uz/index.php/gtfj/article/view/6345
HarvardKamilova I.A., Khikmatullayeva L.I (2026) ‘OPHTHALMIC ARTERY DOPPLER AND ANGIOGENIC BIOMARKERS IN THE PREDICTION OF PREECLAMPSIA: CURRENT EVIDENCE AND FUTURE PERSPECTIVES’, Гуманитар ва табиий фанлар журнали, (36), 50-57. https://journals.tnmu.uz/index.php/gtfj/article/view/6345
BibTeX
@article{kamilovaiakhikmatullayevali2026,
  title = {OPHTHALMIC ARTERY DOPPLER AND ANGIOGENIC BIOMARKERS IN THE PREDICTION OF PREECLAMPSIA: CURRENT EVIDENCE AND FUTURE PERSPECTIVES},
  author = {Kamilova I.A., Khikmatullayeva L.I.},
  journal = {Гуманитар ва табиий фанлар журнали},
  year = {2026},
  number = {36},
  pages = {50-57},
  url = {https://journals.tnmu.uz/index.php/gtfj/article/view/6345}
}

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