Formation and characterization of polymer-dissolving microneedles for the transdermal delivery systems

Khurshidabonu Burkhonova, Khaydar Yunusov, Abdushukur Sarymsakov, Abdumutollib Аtakhanov, Guohua Jiang, Yanfang Sun

O'ZBEKISTON POLIMERLAR JURNALI · 2026-yil

Annotatsiya

Dissolving polymer microneedles based on hydroxypropyl methylcellulose (HPMC), sodium carboxymethylcellulose (Na-CMC), polyvinyl alcohol (PVA), and their binary hydrogel blends were fabricated using a micromolding technique and systematically characterized. The influence of polymer type, concentration, viscosity, and blending on microneedle formation, mechanical properties, and dissolution behavior was investigated. Successful microneedle formation was achieved using 4–5% HPMC, 4–5% Na-CMC, and 10% PVA hydrogels, while all binary polymer systems (HPMC/CMC, HPMC/PVA, and CMC/PVA) demonstrated improved mold filling, tip sharpness, and structural stability. FTIR analysis confirmed the presence of characteristic functional groups in HPMC, Na-CMC, and PVA and revealed pronounced intermolecular interactions in the polymer blends, primarily hydrogen bonding, dipole–dipole, and ion–dipole interactions, indicating enhanced molecular compatibility and structural integrity of the microneedle matrices. Mechanical testing showed that binary polymer systems exhibited improved mechanical properties compared with single-polymer microneedles. In particular, the HPMC/PVA blend demonstrated the highest tensile strength (98 MPa) and elongation at break (7%), indicating synergistic interactions between the polymers. The addition of glycerol as a plasticizer increased flexibility, with an optimal concentration of approximately 0.3 wt% providing a balanced combination of tensile strength and elongation. Dissolution studies performed using an agarose-based skin model demonstrated rapid hydration and progressive dissolution of HPMC/CMC microneedles, with near-complete dissolution occurring within 10 min after insertion. These findings indicate that HPMC, Na-CMC, and PVA hydrogels, particularly their binary blends, represent promising polymer matrices for the development of dissolving microneedle systems for transdermal drug delivery applications.

Maqola ma’lumotlari
MualliflarKhurshidabonu Burkhonova, Khaydar Yunusov, Abdushukur Sarymsakov, Abdumutollib Аtakhanov, Guohua Jiang, Yanfang Sun
JurnalO'ZBEKISTON POLIMERLAR JURNALI
NashriyotПолимерлар кимёси ва физикаси институти, www.polchemphys.uz
ISSN2181-3256, 2181-3248
Nashr sanasi2026-04-02
Jild5
Son1
Betlar52-52
TilIngliz
Ilmiy sohaKimyo
DOI10.66640/ujp-2026-5-00003
Indeksga qo‘shilgan2026-09-02

DOI: 10.66640/ujp-2026-5-00003 · Maqolaning asl sahifasi

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APAKhurshidabonu Burkhonova, Khaydar Yunusov, Abdushukur Sarymsakov, Abdumutollib Аtakhanov, Guohua Jiang, & Yanfang Sun (2026). FORMATION AND CHARACTERIZATION OF POLYMER-DISSOLVING MICRONEEDLES FOR THE TRANSDERMAL DELIVERY SYSTEMS. O'ZBEKISTON POLIMERLAR JURNALI, 5(1), 52-52. https://doi.org/10.66640/ujp-2026-5-00003
GOST (OAK)Khurshidabonu Burkhonova va b. FORMATION AND CHARACTERIZATION OF POLYMER-DISSOLVING MICRONEEDLES FOR THE TRANSDERMAL DELIVERY SYSTEMS // O'ZBEKISTON POLIMERLAR JURNALI. – 2026. – T. 5, № 1. – P. 52-52. – DOI: 10.66640/ujp-2026-5-00003.
MLAKhurshidabonu Burkhonova, Khaydar Yunusov, Abdushukur Sarymsakov, Abdumutollib Аtakhanov, Guohua Jiang, and Yanfang Sun. “FORMATION AND CHARACTERIZATION OF POLYMER-DISSOLVING MICRONEEDLES FOR THE TRANSDERMAL DELIVERY SYSTEMS.” O'ZBEKISTON POLIMERLAR JURNALI, 5(1), 52-52, 2026. https://doi.org/10.66640/ujp-2026-5-00003
ChicagoKhurshidabonu Burkhonova, Khaydar Yunusov, Abdushukur Sarymsakov, Abdumutollib Аtakhanov, Guohua Jiang, and Yanfang Sun. “FORMATION AND CHARACTERIZATION OF POLYMER-DISSOLVING MICRONEEDLES FOR THE TRANSDERMAL DELIVERY SYSTEMS.” O'ZBEKISTON POLIMERLAR JURNALI, 5(1), 52-52 (2026). https://doi.org/10.66640/ujp-2026-5-00003
HarvardKhurshidabonu Burkhonova, Khaydar Yunusov, Abdushukur Sarymsakov, Abdumutollib Аtakhanov, Guohua Jiang, and Yanfang Sun (2026) ‘FORMATION AND CHARACTERIZATION OF POLYMER-DISSOLVING MICRONEEDLES FOR THE TRANSDERMAL DELIVERY SYSTEMS’, O'ZBEKISTON POLIMERLAR JURNALI, 5(1), 52-52. https://doi.org/10.66640/ujp-2026-5-00003
BibTeX
@article{khurshidabonuburkhonova2026,
  title = {FORMATION AND CHARACTERIZATION OF POLYMER-DISSOLVING MICRONEEDLES FOR THE TRANSDERMAL DELIVERY SYSTEMS},
  author = {Khurshidabonu Burkhonova and Khaydar Yunusov and Abdushukur Sarymsakov and Abdumutollib Аtakhanov and Guohua Jiang and Yanfang Sun},
  journal = {O'ZBEKISTON POLIMERLAR JURNALI},
  year = {2026},
  volume = {5},
  number = {1},
  pages = {52-52},
  doi = {10.66640/ujp-2026-5-00003},
  url = {https://doi.org/10.66640/ujp-2026-5-00003}
}

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