Experience in the use of PDE-5 inhibitors (sildenafil) in the management of preeclamsia: case report

Садиков Шавкат Ахмедович, Жолымбетов Исламбек Пазылбекович, Юсупбаев Рустам Базарбаевич

Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) · 2023-yil

Annotatsiya

In a healthy pregnancy, placental development causes fetal cytotrophoblast cells to infiltrate maternal uterine spiral arterioles, changing the vascular endothelium from an epithelial to an endothelial phenotype, leading to greater blood supply with less resistance. In preeclampsia, trophoblastic invasion is impaired, leading to vascular remodeling that fails to provide adequate blood circulation through spiral arterioles, causing hypoxia and placental ischemia. This environment leads to increased oxidative stress and release of inflammatory cytokines, leading to overall systemic maternal endothelial dysfunction. For the reasons mentioned above, the use of PDE inhibitors is recommended as a treatment for preeclampsia. Inhibition of PDE-5 by sildenafil promotes systemic maternal vasodilation and blood pressure reduction. In addition, it prevents hydrolysis of sGMP, increases its intracellular concentration and reduces uteroplacental hypoperfusion, reduces fetal hypoxia, prolongs pregnancy and improves postpartum outcomes.

Maqola ma’lumotlari
MualliflarСадиков Шавкат Ахмедович, Жолымбетов Исламбек Пазылбекович, Юсупбаев Рустам Базарбаевич
JurnalJournal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали)
NashriyotСамарқанд давлат тиббиёт университети
ISSN2017-2021
Nashr sanasi2023-09-22
Jild4
Son4
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

преэклампсия, гестационная гипертензия, вазодилятация, ингибиторы ФДЭ-5, сильденафил, тадалафил, Preeclampsia, gestational hypertension, vasodilation, PDE-5 inhibitors, sildenafil, tadalafil, Preeklampsiya, gestatsion gipertenziya, vazodilyatatsiya, PDE-5 ingibitorlari, sildenafil, tadalafil

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Iqtibos keltirish

APAСадиков Шавкат Ахмедович, Жолымбетов Исламбек Пазылбекович, & Юсупбаев Рустам Базарбаевич (2023). EXPERIENCE IN THE USE OF PDE-5 INHIBITORS (SILDENAFIL) IN THE MANAGEMENT OF PREECLAMSIA: CASE REPORT. Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали), 4(4). https://tadqiqot.uz/index.php/uro/article/view/8019
GOST (OAK)Садиков Шавкат Ахмедович, Жолымбетов Исламбек Пазылбекович, Юсупбаев Рустам Базарбаевич EXPERIENCE IN THE USE OF PDE-5 INHIBITORS (SILDENAFIL) IN THE MANAGEMENT OF PREECLAMSIA: CASE REPORT // Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали). – 2023. – T. 4, № 4.
MLAСадиков Шавкат Ахмедович, Жолымбетов Исламбек Пазылбекович, and Юсупбаев Рустам Базарбаевич. “EXPERIENCE IN THE USE OF PDE-5 INHIBITORS (SILDENAFIL) IN THE MANAGEMENT OF PREECLAMSIA: CASE REPORT.” Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали), 4(4), 2023. https://tadqiqot.uz/index.php/uro/article/view/8019
ChicagoСадиков Шавкат Ахмедович, Жолымбетов Исламбек Пазылбекович, and Юсупбаев Рустам Базарбаевич. “EXPERIENCE IN THE USE OF PDE-5 INHIBITORS (SILDENAFIL) IN THE MANAGEMENT OF PREECLAMSIA: CASE REPORT.” Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали), 4(4) (2023). https://tadqiqot.uz/index.php/uro/article/view/8019
HarvardСадиков Шавкат Ахмедович, Жолымбетов Исламбек Пазылбекович, and Юсупбаев Рустам Базарбаевич (2023) ‘EXPERIENCE IN THE USE OF PDE-5 INHIBITORS (SILDENAFIL) IN THE MANAGEMENT OF PREECLAMSIA: CASE REPORT’, Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали), 4(4). https://tadqiqot.uz/index.php/uro/article/view/8019
BibTeX
@article{article2023,
  title = {EXPERIENCE IN THE USE OF PDE-5 INHIBITORS (SILDENAFIL) IN THE MANAGEMENT OF PREECLAMSIA: CASE REPORT},
  author = {Садиков Шавкат Ахмедович and Жолымбетов Исламбек Пазылбекович and Юсупбаев Рустам Базарбаевич},
  journal = {Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали)},
  year = {2023},
  volume = {4},
  number = {4},
  url = {https://tadqiqot.uz/index.php/uro/article/view/8019}
}

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