In a healthy pregnancy, placental development causes fetal cytotrophoblast cells to infiltrate maternal uterine spiral arterioles, changing the vascular endothelium from an epithelial to an endothelial phenotype, leading to greater blood supply with less resistance. In preeclampsia, trophoblastic invasion is impaired, leading to vascular remodeling that fails to provide adequate blood circulation through spiral arterioles, causing hypoxia and placental ischemia. This environment leads to increased oxidative stress and release of inflammatory cytokines, leading to overall systemic maternal endothelial dysfunction. For the reasons mentioned above, the use of PDE inhibitors is recommended as a treatment for preeclampsia. Inhibition of PDE-5 by sildenafil promotes systemic maternal vasodilation and blood pressure reduction. In addition, it prevents hydrolysis of sGMP, increases its intracellular concentration and reduces uteroplacental hypoperfusion, reduces fetal hypoxia, prolongs pregnancy and improves postpartum outcomes.
С.С.Садирова, С.У. Иргашева · Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) · 2023-09-22
This article provides an analysis of the evaluation of the results of the test with letrozole in women of reproductive age with polycystic ovary syndrome in Uzbekistan. The aim of the study was to evaluate the…
Насирова Зебинисо Азизовна, Расулова Парвина Рустамовна, Сафарова Диёра Фархадовна · Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) · 2023-09-22
During the COVID-19 pandemic, many women faced the problem of excessive weight gain during pregnancy. This was caused not only by a change in lifestyle, but also by the stress experienced by many people due to the…
Шамсиева Зулфия Илхомжон кизи, Жолымбетов Исламбек Пазылбекович · Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) · 2023-09-22
Obesity is a medical, socio-economic problem in modern medicine, the relevance of which is related to the very wide prevalence of obesity. Despite the continuous improvement of the system of antenatal care and obstetric…
Насирова Зебинисо Азизовна · Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) · 2023-09-22
In this work, we analyzed the frequency of violations of the vaginal microbiota in women who had a new coronavirus infection SARS-COV-2. Currently, the frequency of infectious and inflammatory diseases in gynecology…
Надырханова Наталья Суратовна, Ашурова Венера Иргашевна, Ахмедова Ширин Абдуллаевна, Умирзаков Лазиз Абдугаффарович, Жолымбетов Исламбек Пазылбекович · Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) · 2023-09-22
The article provides information on reforms in the field of obstetrics and gynecology in the Republic of Uzbekistan, their results are considered, their effectiveness is assessed. Also, the information on visits…
Набиева Ранохон Музаффар кизи, Каюмова Дилрабо Талмасовна, Атаходжаева Фотима Абдураимовна · Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) · 2023-09-22
Hypertensive disorders in pregnancy are one of the main causes of maternal and perinatal mortality and morbidity in Uzbekistan and around the world, regardless of the level of development and medical care. Aim: to study…
Каттаходжаева Махмуда Хамдамовна, Кодырова Зебинисо Нуридуллаевна · Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) · 2023-09-22
At the present stage of development of medicine in the clinical practice of an obstetrician-gynecologist, when a number of benign diseases of the cervix and CIN are detected, the most common methods of surgical…
Жолымбетов Исламбек Пазылбекович, Юсупбаев Рустам Базарбаевич · Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) · 2023-09-22
Fetoplacental insufficiency is a deterioration in nutrition, gas exchange and excretion of fetal waste products, which are caused by a violation of the functional state and structure of the placenta. No matter how…
Бабаханова Азиза Муратджановна, Даулетова Мехрибан Жарылкасыновна · Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) · 2023-09-22
The article provides information about the possibility of prolonging pregnancy to the optimal period in women with severe disorders of the uterine-fetal-placental system. The studies were carried out in 2021-2023 at the…
Якубова Олтиной Абдуганиевна · Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) · 2023-09-21
The dysmenorrhea is listed in publications of a number of researchers among manifestations of the dysmorphism of connecting tissue (DCT). It is standard to estimate metabolism of a collagen by means of definition…