Thrombotic storm: clinical profile and differential diagnosis of catastrophic antiphospholipid syndrome in pregnancy

Z. A. Radjabova

Ўзбекистон метрологияси · 2025-yil

Annotatsiya

The objective is to identify and systematize the characteristic clinical, laboratory, and instrumental features of catastrophic antiphospholipid syndrome (CAPS) in pregnant women, thereby improving its timely diagnosis and differentiation from other thrombotic microangiopathies (TMAs). Materials and Methods: A cohort study of 12 patients diagnosed with CAPS that developed during pregnancy was conducted. A detailed analysis of the clinical picture, obstetric and perinatal outcomes, biochemical and hemostatic markers, as well as dopplerometry data was performed. Results: It was established that the clinical profile of CAPS is characterized by the rapid development of multi-organ failure with predominant kidney involvement (median creatinine 74.90 μmol/L). The syndrome is associated with extremely adverse perinatal outcomes. Conclusion: CAPS in pregnancy has a unique clinical and laboratory pattern, the key elements of which are a triad: acute kidney injury, an exceedingly high D-dimer level, and a confirmed high titer of aPL. The identification of this triad is crucial for differential diagnosis and the immediate initiation of life-saving therapy.

Maqola ma’lumotlari
MualliflarZ. A. Radjabova
JurnalЎзбекистон метрологияси
NashriyotЎзбекистон техник жиҳатдан тартибга солиш агентлиги
ISSN2181-3663
Nashr sanasi2025-07-15
Jild4
Son1
Betlar66-70
TilIngliz
Ilmiy sohaTexnika
DOI10.47689/2181-3663-vol4-iss1-pp66-70
Indeksga qo‘shilgan2026-09-02

DOI: 10.47689/2181-3663-vol4-iss1-pp66-70 · Maqolaning asl sahifasi · PDF

Ilmiy soha

Texnika

Iqtibos keltirish

APAZ. A. Radjabova (2025). Thrombotic storm: clinical profile and differential diagnosis of catastrophic antiphospholipid syndrome in pregnancy. Ўзбекистон метрологияси, 4(1), 66-70. https://doi.org/10.47689/2181-3663-vol4-iss1-pp66-70
GOST (OAK)Z. A. Radjabova Thrombotic storm: clinical profile and differential diagnosis of catastrophic antiphospholipid syndrome in pregnancy // Ўзбекистон метрологияси. – 2025. – T. 4, № 1. – P. 66-70. – DOI: 10.47689/2181-3663-vol4-iss1-pp66-70.
MLAZ. A. Radjabova. “Thrombotic storm: clinical profile and differential diagnosis of catastrophic antiphospholipid syndrome in pregnancy.” Ўзбекистон метрологияси, 4(1), 66-70, 2025. https://doi.org/10.47689/2181-3663-vol4-iss1-pp66-70
ChicagoZ. A. Radjabova. “Thrombotic storm: clinical profile and differential diagnosis of catastrophic antiphospholipid syndrome in pregnancy.” Ўзбекистон метрологияси, 4(1), 66-70 (2025). https://doi.org/10.47689/2181-3663-vol4-iss1-pp66-70
HarvardZ. A. Radjabova (2025) ‘Thrombotic storm: clinical profile and differential diagnosis of catastrophic antiphospholipid syndrome in pregnancy’, Ўзбекистон метрологияси, 4(1), 66-70. https://doi.org/10.47689/2181-3663-vol4-iss1-pp66-70
BibTeX
@article{zaradjabova2025,
  title = {Thrombotic storm: clinical profile and differential diagnosis of catastrophic antiphospholipid syndrome in pregnancy},
  author = {Z. A. Radjabova},
  journal = {Ўзбекистон метрологияси},
  year = {2025},
  volume = {4},
  number = {1},
  pages = {66-70},
  doi = {10.47689/2181-3663-vol4-iss1-pp66-70},
  url = {https://doi.org/10.47689/2181-3663-vol4-iss1-pp66-70}
}

Boshqa maqola uchun iqtibos tayyorlash

Ўзбекистон метрологияси jurnalidan boshqa maqolalar

Ўзбекистон метрологияси — barcha maqolalar · 2025-yil arxivi

Texnika sohasidagi boshqa maqolalar

Texnika sohasidagi OAK jurnallari