Effect of sugar substitutes on carbohydrate metabolism and their possible role in the development of type 2 diabetes

S.M. Xabibullayev, N.M. Yuldashev, N.T. Mirakbarova

Shoshilinch tibbiyot axborotnomasi · 2023-yil

Annotatsiya

Aim. The effect of fructose, a natural sugar substitute, on the amount of glucose and insulin in the blood ofrats was studied under experimental conditions.Material and method. 25 white male experimental rats weighing 160–180 g were selected. Syntheticfructose dissolved in distilled water in the amount of 600 mg/kg was administered orally to experimentalrats. The research was conducted using biochemical, immunoassay and statistical methods. The amountsof glucose, insulin, total protein, albumin, ALT, AST, urea, creatinine, cholesterol, triglyceride, high-directlipoprotein (HDL), low direct lipoprotein (LDL), Na, Ca, K elements were determined from the blood serum of experimental animals.Results. On the 15th day of the experiment, the amount of glucose in the blood serum of the animalsincreased by 29,3% compared to the control indicator, and on the 30th day by 59,5%. At day 30, theseincreases were statistically significant (p>0,05). The amount of insulin increased by 88,5% (p>0,001) fromthe control indicator on the 15th day of the experiment, and by 68,9% (p>0,001) on the 30th day. Whenthe body weight of the animals was checked, it was found that it increased by 10,9% on the 15th day, and24,4% on the 30th day compared to the control group. Increased body weight, significant increase in glucose, insulin, cholesterol, triglyceride and low-direct lipoproteins led to the development of hyperglycemiaand obesity.Conclusion. Fructose, a sugar substitute, plays a role in the development of type 2 diabetes. Also, fructose affects the metabolism of fats in the body and can be one of the main reasons for the development ofobesity.

Maqola ma’lumotlari
MualliflarS.M. Xabibullayev, N.M. Yuldashev, N.T. Mirakbarova
JurnalShoshilinch tibbiyot axborotnomasi
NashriyotЎзбекистон шошилинч тиббий ёрдам врачлари, ассоциацияси
ISSN2010-9881
Nashr sanasi2023-01-01
Jild15
Son6
TilIngliz
Ilmiy sohaTibbiyot
DOI10.54185/tbem/vol15_iss6/a6
Indeksga qo‘shilgan2026-09-02

DOI: 10.54185/tbem/vol15_iss6/a6 · Maqolaning asl sahifasi · PDF

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAS.M. Xabibullayev, N.M. Yuldashev, & N.T. Mirakbarova (2023). Effect of sugar substitutes on carbohydrate metabolism and their possible role in the development of type 2 diabetes. Shoshilinch tibbiyot axborotnomasi, 15(6). https://doi.org/10.54185/tbem/vol15_iss6/a6
GOST (OAK)S.M. Xabibullayev, N.M. Yuldashev, N.T. Mirakbarova Effect of sugar substitutes on carbohydrate metabolism and their possible role in the development of type 2 diabetes // Shoshilinch tibbiyot axborotnomasi. – 2023. – T. 15, № 6. – DOI: 10.54185/tbem/vol15_iss6/a6.
MLAS.M. Xabibullayev, N.M. Yuldashev, and N.T. Mirakbarova. “Effect of sugar substitutes on carbohydrate metabolism and their possible role in the development of type 2 diabetes.” Shoshilinch tibbiyot axborotnomasi, 15(6), 2023. https://doi.org/10.54185/tbem/vol15_iss6/a6
ChicagoS.M. Xabibullayev, N.M. Yuldashev, and N.T. Mirakbarova. “Effect of sugar substitutes on carbohydrate metabolism and their possible role in the development of type 2 diabetes.” Shoshilinch tibbiyot axborotnomasi, 15(6) (2023). https://doi.org/10.54185/tbem/vol15_iss6/a6
HarvardS.M. Xabibullayev, N.M. Yuldashev, and N.T. Mirakbarova (2023) ‘Effect of sugar substitutes on carbohydrate metabolism and their possible role in the development of type 2 diabetes’, Shoshilinch tibbiyot axborotnomasi, 15(6). https://doi.org/10.54185/tbem/vol15_iss6/a6
BibTeX
@article{smxabibullayev2023,
  title = {Effect of sugar substitutes on carbohydrate metabolism and their possible role in the development of type 2 diabetes},
  author = {S.M. Xabibullayev and N.M. Yuldashev and N.T. Mirakbarova},
  journal = {Shoshilinch tibbiyot axborotnomasi},
  year = {2023},
  volume = {15},
  number = {6},
  doi = {10.54185/tbem/vol15_iss6/a6},
  url = {https://doi.org/10.54185/tbem/vol15_iss6/a6}
}

Boshqa maqola uchun iqtibos tayyorlash

Shoshilinch tibbiyot axborotnomasi jurnalidan boshqa maqolalar

Shoshilinch tibbiyot axborotnomasi — barcha maqolalar · 2023-yil arxivi

Tibbiyot sohasidagi boshqa maqolalar

Tibbiyot sohasidagi OAK jurnallari