Research of the effect of a new antihypoxant and antioxidant agent in experimental hypoxia caused by acute blood loss

Zh Khuzhakhmedov, L. V. Shevchenko, Hamid Yakubovich Karimov, Timur Alimov, R Rakhmanberdieva

Shoshilinch tibbiyot axborotnomasi · 2021-yil

Annotatsiya

Aim. To study the antihypoxic and antioxidant effect of the new blood substitute «Rheoambrasol» in acute blood loss.Material and methods. The experiments were carried out on 60 rats, in which the experimental model of acute blood loss was reproduced. The effectiveness of using the new blood substitute «Rheoambrasol” in acute blood loss was determined in comparison with the drug “Rheopolyglyukin”.Results. The results obtained, it can be seen that blood loss is accompanied by hypoxia, as evidenced by the concentration of hypoxia-inducible factor (HIF-1α), which increased in the second group by 4.1 times. After the infusion of “Rheoambrasol”, the content of hypoxia-inducible factor HIF-1α in blood plasma decreased 2.9 times, compared with the value after blood loss, which was 44.4% lower than after the infusion of the drug “Rheopolyglucin”. After the use of the drug “Rheoambrasol”, the balance of lipid peroxidation activity/ antioxidant system activity (LPO/AOS) in the blood, myocardium and liver was restored. Conclusion. The new drug “Rheoambrasol” has a pronounced antihypoxant effect in acute blood loss, which is manifested in the ability to reduce the content of HIF-1α in the blood of experimental animals.The introduction of “Rheoambrasol” in acute blood loss effectively inhibits lipid peroxidation processes in the blood, myocardium and liver and increases the activity of AOS enzymes, which indicates its antioxidant effect.

Maqola ma’lumotlari
MualliflarZh Khuzhakhmedov, L. V. Shevchenko, Hamid Yakubovich Karimov, Timur Alimov, R Rakhmanberdieva
JurnalShoshilinch tibbiyot axborotnomasi
NashriyotЎзбекистон шошилинч тиббий ёрдам врачлари, ассоциацияси
ISSN2010-9881
Nashr sanasi2021-09-20
Jild14
Son3
TilIngliz
Ilmiy sohaTibbiyot
DOI10.54185/tbem/vol14_iss3/a16
Indeksga qo‘shilgan2026-09-02

DOI: 10.54185/tbem/vol14_iss3/a16 · Maqolaning asl sahifasi · PDF

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Iqtibos keltirish

APAZh Khuzhakhmedov, L. V. Shevchenko, Hamid Yakubovich Karimov, Timur Alimov, & R Rakhmanberdieva (2021). RESEARCH OF THE EFFECT OF A NEW ANTIHYPOXANT AND ANTIOXIDANT AGENT IN EXPERIMENTAL HYPOXIA CAUSED BY ACUTE BLOOD LOSS. Shoshilinch tibbiyot axborotnomasi, 14(3). https://doi.org/10.54185/tbem/vol14_iss3/a16
GOST (OAK)Zh Khuzhakhmedov va b. RESEARCH OF THE EFFECT OF A NEW ANTIHYPOXANT AND ANTIOXIDANT AGENT IN EXPERIMENTAL HYPOXIA CAUSED BY ACUTE BLOOD LOSS // Shoshilinch tibbiyot axborotnomasi. – 2021. – T. 14, № 3. – DOI: 10.54185/tbem/vol14_iss3/a16.
MLAZh Khuzhakhmedov, L. V. Shevchenko, Hamid Yakubovich Karimov, Timur Alimov, and R Rakhmanberdieva. “RESEARCH OF THE EFFECT OF A NEW ANTIHYPOXANT AND ANTIOXIDANT AGENT IN EXPERIMENTAL HYPOXIA CAUSED BY ACUTE BLOOD LOSS.” Shoshilinch tibbiyot axborotnomasi, 14(3), 2021. https://doi.org/10.54185/tbem/vol14_iss3/a16
ChicagoZh Khuzhakhmedov, L. V. Shevchenko, Hamid Yakubovich Karimov, Timur Alimov, and R Rakhmanberdieva. “RESEARCH OF THE EFFECT OF A NEW ANTIHYPOXANT AND ANTIOXIDANT AGENT IN EXPERIMENTAL HYPOXIA CAUSED BY ACUTE BLOOD LOSS.” Shoshilinch tibbiyot axborotnomasi, 14(3) (2021). https://doi.org/10.54185/tbem/vol14_iss3/a16
HarvardZh Khuzhakhmedov, L. V. Shevchenko, Hamid Yakubovich Karimov, Timur Alimov, and R Rakhmanberdieva (2021) ‘RESEARCH OF THE EFFECT OF A NEW ANTIHYPOXANT AND ANTIOXIDANT AGENT IN EXPERIMENTAL HYPOXIA CAUSED BY ACUTE BLOOD LOSS’, Shoshilinch tibbiyot axborotnomasi, 14(3). https://doi.org/10.54185/tbem/vol14_iss3/a16
BibTeX
@article{zhkhuzhakhmedov2021,
  title = {RESEARCH OF THE EFFECT OF A NEW ANTIHYPOXANT AND ANTIOXIDANT AGENT IN EXPERIMENTAL HYPOXIA CAUSED BY ACUTE BLOOD LOSS},
  author = {Zh Khuzhakhmedov and L. V. Shevchenko and Hamid Yakubovich Karimov and Timur Alimov and R Rakhmanberdieva},
  journal = {Shoshilinch tibbiyot axborotnomasi},
  year = {2021},
  volume = {14},
  number = {3},
  doi = {10.54185/tbem/vol14_iss3/a16},
  url = {https://doi.org/10.54185/tbem/vol14_iss3/a16}
}

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