Aim. To study the antihypoxic and antioxidant effect of the new blood substitute «Rheoambrasol» in acute blood loss.Material and methods. The experiments were carried out on 60 rats, in which the experimental model of acute blood loss was reproduced. The effectiveness of using the new blood substitute «Rheoambrasol” in acute blood loss was determined in comparison with the drug “Rheopolyglyukin”.Results. The results obtained, it can be seen that blood loss is accompanied by hypoxia, as evidenced by the concentration of hypoxia-inducible factor (HIF-1α), which increased in the second group by 4.1 times. After the infusion of “Rheoambrasol”, the content of hypoxia-inducible factor HIF-1α in blood plasma decreased 2.9 times, compared with the value after blood loss, which was 44.4% lower than after the infusion of the drug “Rheopolyglucin”. After the use of the drug “Rheoambrasol”, the balance of lipid peroxidation activity/ antioxidant system activity (LPO/AOS) in the blood, myocardium and liver was restored. Conclusion. The new drug “Rheoambrasol” has a pronounced antihypoxant effect in acute blood loss, which is manifested in the ability to reduce the content of HIF-1α in the blood of experimental animals.The introduction of “Rheoambrasol” in acute blood loss effectively inhibits lipid peroxidation processes in the blood, myocardium and liver and increases the activity of AOS enzymes, which indicates its antioxidant effect.
| Mualliflar | Zh Khuzhakhmedov, L. V. Shevchenko, Hamid Yakubovich Karimov, Timur Alimov, R Rakhmanberdieva |
|---|---|
| Jurnal | Shoshilinch tibbiyot axborotnomasi |
| Nashr sanasi | 2021-09-20 |
| Jild | 14 |
| Son | 3 |
| Til | en |
| DOI | 10.54185/tbem/vol14_iss3/a16 |
DOI: 10.54185/tbem/vol14_iss3/a16 · Maqolaning asl sahifasi · PDF
Acute kidney injury is a polyetiologic syndrome that is a sudden decrease in kidney function over several days or weeks, causing the accumulation of nitrogenous compounds in the blood, with or without a decrease in…
Pancreatic trauma is rare from 0.2% to 12% of abdominal injuries, but presents a complex clinical problem due to the erased initial symptoms and the absence of specific clinical signs, which lead to late diagnosis and…
Uzbekistan is a natural habitat for such venomous snakes of the viper family as the Macrovipera lebetinus, Echisand Gloydius. The most dangerous representative of this family in our country is Echis. The venom of…
The article describes the potential of interaction at the junction of the two disciplines for using artificial intelligence to predict the course and severity of the new coronavirus infection COVID-19, including in…
Republic of Uzbekistan.Material and methods. The results of the work of the combustiological service of the Republic of Uzbekistanhave been studied in the period since 2001 to 2020 based on a retrospective analysis. The…
aim. To assess the efficacy and safety of general associated balanced anesthesia based on epidural block during cesarean section in patients with “severe” mitral stenosis.Material and methods. The results of clinical…
По 280 больным изучены современные методы диагностики и результаты миниинвазивных вмешательств.Больным первым этапом выполнены эндоскопические транспапиллярные вмешательства и/ или чрескожные антеградные…
Objective: to study the effect of prehospital thrombolysis on left ventricular systolic dysfunction in patients with acute ST-segment elevation coronary syndrome.Material and methods: The study included 70 patients with…
Aim. Systematization of the experience of the Fergana branch of the RRCEM on the management of victims withisolated and concomitant closed kidney injury.Material and methods. The study included 52 patients with closed…
Aim. Determine the state of the biochemical composition of blood in the midst and resolution of muscle hematomas in patients with hemophilia.Materials and methods. 118 patients with hemophilia were examined. These…